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131.
Hiroshi YAMASHITA Chihiro TANAKA Hiroto NAKAYAMA Nobuko TUNO Naoya OSAWA 《Entomological Science》2005,8(3):223-225
We identified three species of fungivorous scuttle fly –Megaselia flava, M. kanekoi and M. gotoi– from eight fruit bodies of a fungus, Amanita ibotengutake, which has not previously been recorded as the host of these flies. 相似文献
132.
Tomofumi Sakai Yumi Inoue Naoya Terahara Keiichi Namba Tohru Minamino 《Biochemical and biophysical research communications》2018,495(2):1789-1794
The bacterial flagellar hook is a short, curved tubular structure made of FlgE. The hook connects the basal body as a rotary motor and the filament as a helical propeller and functions as a universal joint to smoothly transmit torque produced by the motor to the filament. Salmonella FlgE consists of D0, Dc, D1 and D2 domains. Axial interactions between a triangular loop of domain D1 (D1-loop) and domain D2 are postulated to be responsible for hook supercoiling. In contrast, Bacillus FlgE lacks the D1-loop and domain D2. Here, to clarify the roles of the D1-loop and domain D2 in the mechanical function, we carried out deletion analysis of Salmonella FlgE. A deletion of the D1-loop conferred a loss-of-function phenotype whereas that of domain D2 did not. The D1-loop deletion inhibited hook polymerization. Suppressor mutations of the D1-loop deletion was located within FlgD, which acts as the hook cap to promote hook assembly. This suggests a possible interaction between the D1-loop of FlgE and FlgD. Suppressor mutant cells produced straight hooks, but retained the ability to form a flagellar bundle behind a cell body, suggesting that the loop deletion does not affect the bending flexibility of the Salmonella hook. 相似文献
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135.
Yoshihiro Morinaga Naoya Fujita Kazuo Ohishi Yongke Zhang Takashi Tsuruo 《Journal of cellular physiology》1998,175(3):247-254
We previously found that human melanoma (A375M) and human breast cancer (MDA-MB-231) cells formed osteolytic bone metastasis in vivo. These cancer cells produced interleukin-11 (IL-11) by themselves and stimulated its production from osteoblasts. Interleukin-11 could increase the number of osteoclasts and raise the calcium concentration in the medium of neonatal murine calvaria organ culture, indicating bone resorption in vitro. Therefore, IL-11 could play an important role in the promotion of osteolysis at the site of bone metastasis. In the present study, we used the calvaria culture system to try to clarify the mechanisms of IL-11–mediated bone resorption. The murine calvaria expressed both the specificity-determining α subunit and the signal–transducing β subunit (gp130) of the IL-11 receptor. When IL-11 was added to the calvaria culture, the concentrations of prostaglandin E2 (PGE2) was elevated. Pretreatment of calvaria with cyclooxygenases inhibitors (e.g., indomethacin, NS-398, and dexamethasone) suppressed the production of PGE2 and the bone resorption induced by IL-11. Addition of exogenous PGE2 overcame the inhibitory effect of cyclooxygenases inhibitors and promoted bone resorption. These results indicate that IL-11 promotes bone resorption through a PGE2 synthesis–dependent mechanism and that cyclooxygenases inhibitors could be interesting drugs to suppress IL-11–mediated osteolytic bone metastasis of cancer cells. J. Cell. Physiol. 175:247–254, 1998. © 1998 Wiley-Liss, Inc. 相似文献
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137.
Hidefumi Yoshinaga Shuji Masumoto Koji Koyama Naoya Kinomura Yuji Matsumoto Taro Kato Satoko Baba Kenji Matsumoto Tomoko Horisawa Hitomi Oki Kazuki Yabuuchi Toru Kodo 《Bioorganic & medicinal chemistry》2017,25(1):293-304
We report the discovery of a novel benzylpiperidine derivative with serotonin transporter (SERT) inhibitory activity and 5-HT1A receptor weak partial agonistic activity showing the antidepressant-like effect. The 3-methoxyphenyl group and the phenethyl group of compound 1, which has weak SERT binding activity, but potent 5-HT1A binding activity, were optimized, leading to compound 35 with potent and balanced dual SERT and 5-HT1A binding activity, but also potent CYP2D6 inhibitory activity. Replacement of the methoxy group in the left part of compound 35 with a larger alkoxy group, such as ethoxy, isopropoxy or methoxy-ethoxy group ameliorated CYP2D6 inhibition, giving SMP-304 as a candidate. SMP-304 with serotonin uptake inhibitory activity and 5-HT1A weak partial agonistic activity, which could work as a 5-HT1A antagonist, displayed faster onset of antidepressant-like effect than a representative SSRI paroxetine in an animal model. 相似文献
138.
Tohru Hayakawa Naoya Yoneda Kouji Okada Ayuko Higaki Mohammad Tofazzal Hossain Howlader Toru Ide 《Applied Entomology and Zoology》2017,52(1):61-68
A 2,175-bp modified gene (cry11Ba-S1) encoding Cry11Ba from Bacillus thuringiensis subsp. jegathesan was designed and the recombinant protein was expressed as a fusion protein with glutathione S-transferase in Escherichia coli. The recombinant Cry11Ba was highly toxic against Culex pipiens mosquito larvae, being nine and 17 times more toxic than mosquitocidal Cry4Aa and Cry11Aa from Bacillus thuringiensis subsp. israelensis, respectively. Interestingly, a further increase in the toxicity of the recombinant Cry11Ba was achieved by mixing with Cry4Aa, but not with Cry11Aa. These findings suggested that Cry11Ba worked synergistically with Cry4Aa, but not with Cry11Aa, in exhibiting toxicity against C. pipiens larvae. On the other hand, the amount of Cry toxin bound to brush border membrane vesicles (BBMVs) did not significantly change between individual toxins and the toxin mixtures, suggesting that the increase in toxins binding to BBMVs was not a reason for the observed synergistic effect. It is generally accepted that synergism of toxins is a potentially powerful tool for enhancing insecticidal activity and managing Cry toxin resistance in mosquitoes. The mixture of Cry4Aa and Cry11Ba in order to increase toxicity would be very valuable in terms of mosquito control. 相似文献
139.
Significant Improvement in the Performance of PbSe Quantum Dot Solar Cell by Introducing a CsPbBr3 Perovskite Colloidal Nanocrystal Back Layer
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140.
Abdol Rahim Abbasi Naoya Ihara Toshio Watanabe Maryam Khalaj Takehito Tsuji Yoshikazu Sugimoto Tetsuo Kunieda 《Mammalian genome》2005,16(9):731-737
Congenital multiple ocular defects (MOD) in Japanese black cattle is a hereditary ocular disorder with an autosomal recessive
manner of inheritance, showing developmental defects of the lens, retina, and iris, persistent embryonic eye vascularization,
and microphthalmia. In the present study, we mapped the locus responsible for the disorder by linkage analysis using 240 microsatellite
markers covering the entire bovine genome and an inbred pedigree obtained from commercial herds. The linkage analysis demonstrated
a significant linkage between the disorder locus and markers on the proximal region of bovine Chromosome (BTA) 18 with the
maximum LOD score of 5.1. Homozygosity mapping using the haplotype of the linked markers further refined the critical region.
The results revealed the localization of the locus responsible for MOD in an approximately 6.6-cM region of BTA18. Comparison
of published linkage and radiation hybrid (RH) maps of BTA18 with its evolutionary ortholog, human Chromosome (HSA) 16, revealed
several potential candidate genes for the disorder including the MAF and FOXC2 genes. 相似文献