全文获取类型
收费全文 | 2038篇 |
免费 | 166篇 |
出版年
2023年 | 10篇 |
2022年 | 9篇 |
2021年 | 53篇 |
2020年 | 25篇 |
2019年 | 25篇 |
2018年 | 36篇 |
2017年 | 26篇 |
2016年 | 57篇 |
2015年 | 110篇 |
2014年 | 103篇 |
2013年 | 130篇 |
2012年 | 148篇 |
2011年 | 177篇 |
2010年 | 95篇 |
2009年 | 76篇 |
2008年 | 125篇 |
2007年 | 121篇 |
2006年 | 115篇 |
2005年 | 132篇 |
2004年 | 136篇 |
2003年 | 110篇 |
2002年 | 94篇 |
2001年 | 15篇 |
2000年 | 7篇 |
1999年 | 20篇 |
1998年 | 27篇 |
1997年 | 11篇 |
1996年 | 10篇 |
1995年 | 16篇 |
1994年 | 11篇 |
1993年 | 13篇 |
1992年 | 20篇 |
1991年 | 10篇 |
1990年 | 13篇 |
1989年 | 11篇 |
1988年 | 6篇 |
1987年 | 10篇 |
1986年 | 6篇 |
1985年 | 4篇 |
1984年 | 10篇 |
1983年 | 7篇 |
1982年 | 9篇 |
1981年 | 8篇 |
1980年 | 7篇 |
1979年 | 4篇 |
1978年 | 4篇 |
1976年 | 3篇 |
1974年 | 4篇 |
1973年 | 4篇 |
1972年 | 3篇 |
排序方式: 共有2204条查询结果,搜索用时 609 毫秒
31.
George F. Young Luca Scardovi Andrea Cavagna Irene Giardina Naomi E. Leonard 《PLoS computational biology》2013,9(1)
Flocks of starlings exhibit a remarkable ability to maintain cohesion as a group in highly uncertain environments and with limited, noisy information. Recent work demonstrated that individual starlings within large flocks respond to a fixed number of nearest neighbors, but until now it was not understood why this number is seven. We analyze robustness to uncertainty of consensus in empirical data from multiple starling flocks and show that the flock interaction networks with six or seven neighbors optimize the trade-off between group cohesion and individual effort. We can distinguish these numbers of neighbors from fewer or greater numbers using our systems-theoretic approach to measuring robustness of interaction networks as a function of the network structure, i.e., who is sensing whom. The metric quantifies the disagreement within the network due to disturbances and noise during consensus behavior and can be evaluated over a parameterized family of hypothesized sensing strategies (here the parameter is number of neighbors). We use this approach to further show that for the range of flocks studied the optimal number of neighbors does not depend on the number of birds within a flock; rather, it depends on the shape, notably the thickness, of the flock. The results suggest that robustness to uncertainty may have been a factor in the evolution of flocking for starlings. More generally, our results elucidate the role of the interaction network on uncertainty management in collective behavior, and motivate the application of our approach to other biological networks. 相似文献
32.
33.
34.
Jorim J. Tielbeek Sarah E. Medland Beben Benyamin Enda M. Byrne Andrew C. Heath Pamela A. F. Madden Nicholas G. Martin Naomi R. Wray Karin J. H. Verweij 《PloS one》2012,7(10)
Crime poses a major burden for society. The heterogeneous nature of criminal behavior makes it difficult to unravel its causes. Relatively little research has been conducted on the genetic influences of criminal behavior. The few twin and adoption studies that have been undertaken suggest that about half of the variance in antisocial behavior can be explained by genetic factors. In order to identify the specific common genetic variants underlying this behavior, we conduct the first genome-wide association study (GWAS) on adult antisocial behavior. Our sample comprised a community sample of 4816 individuals who had completed a self-report questionnaire. No genetic polymorphisms reached genome-wide significance for association with adult antisocial behavior. In addition, none of the traditional candidate genes can be confirmed in our study. While not genome-wide significant, the gene with the strongest association (p-value = 8.7×10−5) was DYRK1A, a gene previously related to abnormal brain development and mental retardation. Future studies should use larger, more homogeneous samples to disentangle the etiology of antisocial behavior. Biosocial criminological research allows a more empirically grounded understanding of criminal behavior, which could ultimately inform and improve current treatment strategies. 相似文献
35.
36.
37.
38.
39.
Yulia Mostovoy Feyza Yilmaz Stephen K Chow Catherine Chu Chin Lin Elizabeth A Geiger Naomi J L Meeks Kathryn C Chatfield Curtis R Coughlin II Urvashi Surti Pui-Yan Kwok Tamim H Shaikh 《Genetics》2021,217(2)
Segmental duplications (SDs) are a class of long, repetitive DNA elements whose paralogs share a high level of sequence similarity with each other. SDs mediate chromosomal rearrangements that lead to structural variation in the general population as well as genomic disorders associated with multiple congenital anomalies, including the 7q11.23 (Williams–Beuren Syndrome, WBS), 15q13.3, and 16p12.2 microdeletion syndromes. Population-level characterization of SDs has generally been lacking because most techniques used for analyzing these complex regions are both labor and cost intensive. In this study, we have used a high-throughput technique to genotype complex structural variation with a single molecule, long-range optical mapping approach. We characterized SDs and identified novel structural variants (SVs) at 7q11.23, 15q13.3, and 16p12.2 using optical mapping data from 154 phenotypically normal individuals from 26 populations comprising five super-populations. We detected several novel SVs for each locus, some of which had significantly different prevalence between populations. Additionally, we localized the microdeletion breakpoints to specific paralogous duplicons located within complex SDs in two patients with WBS, one patient with 15q13.3, and one patient with 16p12.2 microdeletion syndromes. The population-level data presented here highlights the extreme diversity of large and complex SVs within SD-containing regions. The approach we outline will greatly facilitate the investigation of the role of inter-SD structural variation as a driver of chromosomal rearrangements and genomic disorders. 相似文献
40.
Yoshikazu Arai Jun Ohgane Shuh‐hei Fujishiro Kazuaki Nakano Hitomi Matsunari Masahito Watanabe Kazuhiro Umeyama Dai Azuma Naomi Uchida Nozomu Sakamoto Tomohiro Makino Shintaro Yagi Kunio Shiota Yutaka Hanazono Hiroshi Nagashima 《Genesis (New York, N.Y. : 2000)》2013,51(11):763-776
Porcine induced pluripotent stem cells (iPSCs) provide useful information for translational research. The quality of iPSCs can be assessed by their ability to differentiate into various cell types after chimera formation. However, analysis of chimera formation in pigs is a labor‐intensive and costly process, necessitating a simple evaluation method for porcine iPSCs. Our previous study identified mouse embryonic stem cell (ESC)‐specific hypomethylated loci (EShypo‐T‐DMRs), and, in this study, 36 genes selected from these were used to evaluate porcine iPSC lines. Based on the methylation profiles of the 36 genes, the iPSC line, Porco Rosso‐4, was found closest to mouse pluripotent stem cells among 5 porcine iPSCs. Moreover, Porco Rosso‐4 more efficiently contributed to the inner cell mass (ICM) of blastocysts than the iPSC line showing the lowest reprogramming of the 36 genes (Porco Rosso‐622‐14), indicating that the DNA methylation profile correlates with efficiency of ICM contribution. Furthermore, factors known to enhance iPSC quality (serum‐free medium with PD0325901 and CHIR99021) improved the methylation status at the 36 genes. Thus, the DNA methylation profile of these 36 genes is a viable index for evaluation of porcine iPSCs. genesis 51:763–776. © 2013 Wiley Periodicals, Inc. 相似文献