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排序方式: 共有280条查询结果,搜索用时 609 毫秒
81.
82.
Norine Voisin Rhonda E. Schnur Sofia Douzgou Susan M. Hiatt Cecilie F. Rustad Natasha J. Brown Dawn L. Earl Boris Keren Olga Levchenko Sinje Geuer Sarah Verheyen Diana Johnson Yuri A. Zarate Miroslava Hančárová David J. Amor E. Martina Bebin Jasmin Blatterer Alfredo Brusco Alexandre Reymond 《American journal of human genetics》2021,108(5):857-873
83.
Brooke Sadler Jackson Wilborn Lilian Antunes Timothy Kuensting Andrew T. Hale Stephen R. Gannon Kevin McCall Carlos Cruchaga Matthew Harms Norine Voisin Alexandre Reymond Gerarda Cappuccio Nicola Brunetti-Pierri Marco Tartaglia Marcello Niceta Chiara Leoni Giuseppe Zampino Allison Ashley-Koch Gabe Haller 《American journal of human genetics》2021,108(3):530-531
84.
Maziade M Rouleau N Cellard C Battaglia M Paccalet T Moreau I Gagnon V Gingras N Marino C Gilbert E Roy MA Mérette C 《PloS one》2011,6(4):e19153
Objective
Neurocognitive dysfunctions analogous to those of adult patients have been detected in children at risk of schizophrenia and bipolar disorder. This led to the following developmental question: Do IQ and memory impairments exhibit different developmental courses from childhood to young adulthood in terms of stability or fluctuations?Methods
In a high risk sample, we used a step by step sampling approach to narrow-down the early disease mechanisms. Upstream, we started with a 20-year follow-up of 48 densely affected multigenerational kindreds, including 1500 clinically characterized adult members. We then identified 400 adult members affected by a DSM-IV schizophrenia or bipolar disorder. Downstream, we finally focused on 65 offspring (of an affected parent) aged 7 to 22, who were administered a neuropsychological battery. We then constructed cross-sectional trajectories that were compared to those of controls.Results
The childhood IQ deficit displayed a stability until young adulthood. The delay in visual memory exhibited a non-linear two-stage trajectory: a lagging period during childhood followed by a recuperation period from adolescence until adulthood, as supported by a significant Group x Age Periods interaction. No data suggested deterioration between 7 and 22.Conclusion
In these offspring at genetic risk, the developmental trajectory of global IQ impairment may not apply to specific domains of cognition such as episodic memory. Different cognitive dysfunctions would mark different developmental courses. The shape of the trajectories might itself have a meaning and provide empirical leads for targeting the right dysfunction at the right time in future prevention research. 相似文献85.
Lymphocyte trafficking and migration through vascular endothelial cells (ECs) in secondary lymphoid tissues is critical for immune protection. In the present study, we investigate the role of nectin cell adhesion molecules for the migration of lymphocytes through ECs. Nectins are key players for the establishment of homotypic and heterotypic cell to cell contacts; they are required for cell to cell adherens junction formation and take part in the transendothelial migration of monocytes during the step of diapedesis, when monocytes migrate through EC junctions. We first show that Nectin-3 (CD113) is the only nectin expressed by T lymphocytes and since nectins are expressed on ECs we explored Nectin-3 potential functions in lymphocyte: EC interactions. We demonstrate that Nectin-2, expressed on ECs, is the major counter-receptor of Nectin-3. A soluble form of Nectin-3 binds to Nectin-2 localized at EC junctions and blocking Nectin-2 trans-interactions with monoclonal antibodies abolishes the binding of soluble Nectin-3 to ECs. Nectin-2 is expressed on High Endothelial venules (HEVs), where lymphocyte homing occurs in vivo. Finally, we show that Nectin-3 trans-interaction with Nectin-2 is essential for the process of lymphocyte transendothelial migration in vitro as targeting with blocking monoclonal antibodies either Nectin-3, expressed on lymphocytes, or Nectin-2, expressed on ECs, inhibits lymphocyte extravasation. The nectin family of CAMs is important for the regulation of endothelial barrier functions and transendothelial migration of immune cells. Our results demonstrate for the first time that Nectin-3 trans-interacts with Nectin-2 to promote lymphocyte and monocyte extravasation. 相似文献
86.
Gražvydas Lukinavičius Darja Lavogina Meritxell Orpinell Keitaro Umezawa Luc Reymond Nathalie Garin Pierre Gönczy Kai Johnsson 《Current biology : CB》2013,23(3):265-270
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87.
Alexandre Fournier‐Level Amity M. Wilczek Martha D. Cooper Judith L. Roe Jillian Anderson Deren Eaton Brook T. Moyers Renee H. Petipas Robert N. Schaeffer Bjorn Pieper Matthieu Reymond Maarten Koornneef Stephen M. Welch David L. Remington Johanna Schmitt 《Molecular ecology》2013,22(13):3552-3566
Selection on quantitative trait loci (QTL) may vary among natural environments due to differences in the genetic architecture of traits, environment‐specific allelic effects or changes in the direction and magnitude of selection on specific traits. To dissect the environmental differences in selection on life history QTL across climatic regions, we grew a panel of interconnected recombinant inbred lines (RILs) of Arabidopsis thaliana in four field sites across its native European range. For each environment, we mapped QTL for growth, reproductive timing and development. Several QTL were pleiotropic across environments, three colocalizing with known functional polymorphisms in flowering time genes (CRY2, FRI and MAF2‐5), but major QTL differed across field sites, showing conditional neutrality. We used structural equation models to trace selection paths from QTL to lifetime fitness in each environment. Only three QTL directly affected fruit number, measuring fitness. Most QTL had an indirect effect on fitness through their effect on bolting time or leaf length. Influence of life history traits on fitness differed dramatically across sites, resulting in different patterns of selection on reproductive timing and underlying QTL. In two oceanic field sites with high prereproductive mortality, QTL alleles contributing to early reproduction resulted in greater fruit production, conferring selective advantage, whereas alleles contributing to later reproduction resulted in larger size and higher fitness in a continental site. This demonstrates how environmental variation leads to change in both QTL effect sizes and direction of selection on traits, justifying the persistence of allelic polymorphism at life history QTL across the species range. 相似文献
88.
Dean KE Klein G Renaudet O Reymond JL 《Bioorganic & medicinal chemistry letters》2003,13(10):1653-1656
The water soluble fluorescein-based ligand 1 forms a non-fluorescent complex with Cu(2+). This complex serves as a fluorescent sensor for amino acids in the 10(-3) M concentration range. Since the signal response is very fast, the sensor can be used to detect the hydrolytic activity of various proteases (trypsin, chymotrypsin, subtilisin) on bovine serum albumin as a whole protein substrate, and more generally to follow reactions releasing or removing free amino acids, in real time. 相似文献
89.
90.
Natural variation in the degree of autonomous endosperm formation reveals independence and constraints of embryo growth during seed development in Arabidopsis thaliana
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Ungru A Nowack MK Reymond M Shirzadi R Kumar M Biewers S Grini PE Schnittger A 《Genetics》2008,179(2):829-841
Seed development in flowering plants is a paradigm for the coordination of different tissues during organ growth. It requires a tight interplay between the two typically sexually produced structures: the embryo, developing from the fertilized egg cell, and the endosperm, originating from a fertilized central cell, along with the surrounding maternal tissues. Little is known about the presumptive signal transduction pathways administering and coordinating these different tissues during seed growth and development. Recently, a new signal has been identified emanating from the fertilization of the egg cell that triggers central cell proliferation without prior fertilization. Here, we demonstrate that there exists a large natural genetic variation with respect to the outcome of this signaling process in the model plant Arabidopsis thaliana. By using a recombinant inbred line population between the two Arabidopsis accessions Bayreuth-0 and Shahdara, we have identified two genetic components that influence the development of unfertilized endosperm. Exploiting this natural variation, we could further dissect the interdependence of embryo and endosperm growth during early seed development. Our data show an unexpectedly large degree of independence in embryo growth, but also reveal the embryo's developmental restrictions with respect to endosperm size. This work provides a genetic framework for dissection of the interplay between embryo and endosperm during seed growth in plants. 相似文献