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991.
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993.
Kohji Seio Munefumi Tokugawa Hirosuke Tsunoda Akihiro Ohkubo Fumio Arisaka Mitsuo Sekine 《Bioorganic & medicinal chemistry letters》2013,23(24):6822-6824
The structural properties of a DNA/RNA duplex having a pyrene residue at the 5′ end of DNA and a G-rich single strand region at the 3′ end of RNA were studied in detail. Fluorescence and ultracentrifugation analyses indicated the formation of a complex containing four DNA/RNA duplexes, which required a pyrene residue, G-rich sequence, RNA-type backbone, and high salt concentration. 相似文献
994.
Hisateru Mitsuda Kazuo Murakami Fumio Kawai 《Bioscience, biotechnology, and biochemistry》2013,77(5):366-372
The inhibition of chlorophenol analogues on oxidative phosphorylation in rat liver mitochondria was studied using polarographic technique and some new findings that not only pentachlorophenol (PCP) but also other analogues inhibited the oxidative phoshorylation in a similar manner were made. The inhibitory activity was found to be roughly correlated with its dissociation constant of the inhibitor, PCP being the strongest, varying with the number and position of chlorine atoms in the molecule. The mode of the inhibition was classified into three types and discussed in detail. 相似文献
995.
Yoshiyuki Tohno Setsuko Tohno Takeshi Minami Yumi Moriwake Masako Utsumi Fumio Nishiwaki Masa-Oki Yamada 《Biological trace element research》1998,63(2):105-111
To elucidate the relationships between the decrease of mineral contents in human bones and the accumulation of minerals in
the other human tissues, the relative contents (RCs) of calcium were analyzed by inductively coupled plasma atomic emission
spectrometry among human bones, arteries, veins, and cartilages in 27 subjects (17 men and 10 women). These were resected
from subjects who died in the age range from 40 to 98 yr old. Calcanei were chosen for analysis of mineral contents in contrast
with femoral, popliteal and common carotid arteries, internal jugular veins, and pubic symphysis.
It was found that the RCs of calcium in calcanei were agreeable to association with those in both the pubic symphysis and
the femoral artery, but they were not agreeable to association with those in the popliteal and common carotid arteries, and
the internal jugular veins. This suggests that calcium released from bones is accompanied by accumulations of calcium in the
artery and cartilage. 相似文献
996.
997.
Ken Ohashi Fumio Takizawa Norihiro Tokumaru Chihaya Nakayasu Hideaki Toda Uwe Fischer Tadaaki Moritomo Keiichiro Hashimoto Teruyuki Nakanishi Johannes Martinus Dijkstra 《Immunogenetics》2010,62(8):543-559
In teleost fish, a novel gene G6F-like was identified, encoding a type I transmembrane molecule with four extracellular Ig-like domains and a cytoplasmic tail with
putative tyrosine phosphorylation motifs including YxN and an immunoreceptor tyrosine-based activation motif (ITAM). G6F-like maps to a teleost genomic region where stretches corresponding to human chromosomes 6p (with the MHC), 12p (with CD4 and LAG-3), and 19q are tightly linked. This genomic organization resembles the ancestral “Ur-MHC” proposed for the jawed vertebrate
ancestor. The deduced G6F-like molecule shows sequence similarity with members of the CD4/LAG-3 family and with the human
major histocompatibility complex-encoded thrombocyte marker G6F. Despite some differences in molecular organization, teleost
G6F-like and tetrapod G6F seem orthologous as they map to similar genomic location, share typical motifs in transmembrane
and cytoplasmic regions, and are both expressed by thrombocytes/platelets. In the crucian carps goldfish (Carassius auratus auratus) and ginbuna (Carassius auratus langsdorfii), G6F-like was found expressed not only by thrombocytes but also by erythrocytes, supporting that erythroid and thromboid
cells in teleost fish form a hematopoietic lineage like they do in mammals. The ITAM-bearing of G6F-like suggests that the
molecule plays an important role in cell activation, and G6F-like expression by erythrocytes suggests that these cells have
functional overlap potential with thrombocytes. 相似文献
998.
999.
Toshitake Kobayashi Satoshi Sasaki Naoki Tomita Seiji Fukui Noritaka Kuroda Masaharu Nakayama Atsushi Kiba Yoshihiro Takatsu Tetsuya Ohtaki Fumio Itoh Atsuo Baba 《Bioorganic & medicinal chemistry》2010,18(11):3841-3859
GPR54 is a G protein-coupled receptor (GPCR) which was formerly an orphan receptor. Recent functional study of GPR54 revealed that the receptor has an essential role to modulate sex-hormones including GnRH. Though antagonists of GPR54 are expected to be novel drugs for sex-hormone dependent diseases such as prostate cancer or endometriosis, small molecule GPR54 antagonists have not been reported. We have synthesized a series of 2-acylamino-4,6-diphenylpyridines to identify potent GPR54 antagonists. Detailed structure–activity relationship studies led to compound 9l with an IC50 value of 3.7 nM in a GPR54 binding assay, and apparent antagonistic activity in a cellular functional assay. 相似文献
1000.