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991.
Synthesis and biological activity of N-substituted aminocarbonyl-1,3-dioxolanes as VLA-4 antagonists
Abdul Rehman Ajay Soni Keshav Naik Sreeji Nair Venkata P. Palle Sunanda Dastidar Abhijit Ray M.S. Alam Mohammad Salman Ian A. Cliffe Viswajanani Sattigeri 《Bioorganic & medicinal chemistry letters》2010,20(18):5514-5520
A novel set of compounds with a 1,3-dioxolane ring which acts as a proline bioisostere have been successfully designed as VLA-4 receptor antagonists. Compounds (18e), (28j), and (35g) were shown to have high receptor affinities. 相似文献
992.
993.
Reductions in water,soil and nutrient losses and pesticide pollution in agroforestry practices: a review of evidence and processes 总被引:1,自引:0,他引:1
Zhu Xiai Liu Wenjie Chen Jin Bruijnzeel L. Adrian Mao Zhun Yang Xiaodong Cardinael Rémi Meng Fan-Rui Sidle Roy C. Seitz Steffen Nair Vimala D. Nanko Kazuki Zou Xin Chen Chunfeng Jiang Xiao Jin 《Plant and Soil》2020,453(1-2):45-86
Plant and Soil - Agroforestry systems combining trees with crops or pastures have been widely used to reduce water, soil, and nutrient losses and associated water pollution from agricultural lands... 相似文献
994.
E. Petter Axelsson Kevin C. Grady Maria L. T. Lardizabal Ignatius B. S. Nair Daideth Rinus Ulrik Ilstedt 《Restoration Ecology》2020,28(1):156-165
Effective reforestation of degraded tropical forests depends on selecting planting material suited to the stressful environments typical at restoration sites that can be exacerbated by increased duration and intensity of dry spells expected with climate change. While reforestation efforts in nontropical systems are incorporating drought‐adapted genotypes into restoration programs to cope with drier conditions, such approaches have not been tested or implemented in tropical forests. As the first effort to examine genetic variation in plant response to drought in a tropical wet forest, we established a watering experiment using five replicated maternal lines (i.e. seedlings from different maternal trees) of five dipterocarp species native to Borneo. Apart from the expected species level variation in growth and herbivory (3‐fold variation in both cases), we also found intraspecific variation so that growth in some cases varied 2‐fold, and herbivory 3‐fold, among genetically different maternal lines. In two species we found that among‐maternal line variation in growth rate was negatively correlated with tolerance to water limitation, that is, the maternal lines that performed the best in the high water treatment lost proportionally more of their growth during water limitation. We argue that selection for tolerance to future drier conditions is not only likely to impact population genetics of entire forests, but likely extends from forest trees to the communities of canopy arthropods associated with these trees. In tropical reforestation efforts where increased drought is predicted from climate change, including plant material resilient to drier conditions may improve restoration effectiveness. 相似文献
995.
Vandana Tiwari Baleshwar Meena Narayanan K. Nair Tikam S. Rana 《Physiology and Molecular Biology of Plants》2020,26(5):975-984
Bergenia ciliata is an important medicinal plant species of Indian Himalayan Region (IHR). Genetic variability and population genetic structure of B. ciliata sampled from IHR was studied using two single primer amplification reaction (SPAR) methods (DAMD: Directed Amplification of Minisatellite region DNA; ISSR: Inter Simple Sequence Repeats). To provide a reasonable scientific basis for management and conservation of B. ciliata populations in IHR, genetic diversity analysis of 11 populations with 24 SPAR markers (15 ISSR and 9 DAMD) revealed significantly high level of (90.03%) polymorphism at species level. However, genetic variability was low at population level and KUL and BWS populations showed maximum while SHM population revealed least genetic diversity among the 11 populations. Analysis of molecular variance revealed highest percentage of variation (73%) within populations, followed by 17% among populations and least (10%) among the Himalayan regions. Clustering pattern obtained from UPGMA dendrogram was supported by STRUCTURE and principal coordinate analysis, segregating all the 11 natural populations of B. ciliata into two genetic clusters: Eastern and Western Himalayan populations. The clustering patterns of all the three statistical methods indicated that populations of B. ciliata have structured in response to the local micro-climates of the habitats in IHR, and therefore, it can be concluded that genetic variability is in congruence with the geographical diversity. 相似文献
996.
Molecular and Cellular Biochemistry - Metabolic shift is an important contributory factor for progression of hypertension-induced left ventricular hypertrophy into cardiac failure. Under... 相似文献
997.
Patel Bhoomika Sharma Supriya Nair Nisha Majeed Jaseela Goyal Ramesh K. Dhobi Mahaveer 《Molecular and cellular biochemistry》2021,476(6):2345-2364
Molecular and Cellular Biochemistry - The pandemic of Serious Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) that produces corona virus disease (COVID-19) has challenged the entire mankind... 相似文献
998.
Preena P. G. Dharmaratnam Arathi Raj N. Sundar Raja S. Arun Nair Reshma R. Swaminathan T. Raja 《Archives of microbiology》2021,203(1):219-231
Archives of Microbiology - Goldfish farming gained more attention among the ornamental fishes in aquaculture industry. The occurrence of bacterial infections and further antimicrobial treatment... 相似文献
999.
Anil Kumar Aswathy Nandakumar Sajitha Nair Ashutosh Singh Nandita Shashindran Swathy Thulasidharan Kiran Subhash Arya Ramachandran Anuradha Chowdhary 《Revista iberoamericana de micología》2021,38(1):12-15
BackgroundExophiala dermatitidis is a dematiaceous fungus known to cause superficial, subcutaneous, cutaneous and deep seated infections, and rarely central line associated bloodstream infection (CLABSI). A case of CLABSI due to E. dermatitidis in an infant is described.Case reportClinical and laboratory data were extracted from patient's chart and laboratory records. The isolate was identified as E. dermatitidis by phenotypic characterization and sequencing of the ITS and LSU regions of the ribosomal DNA. Medline search was done to review all cases of CLABSI due to E. dermatitidis. Among the azoles tested, posaconazole (0.06 mg/l), voriconazole (0.03 mg/l) and itraconazole (0.03 mg/l) showed very low MICs when compared to fluconazole (4 mg/l)ConclusionsAs we did not found in the literature any case of CLABSI due to E. dermatitidis in an infant, we report the first one. Sequencing is a mandatory method for accurately identifying this species. Prompt removal of the central line, followed by a treatment with amphotericin B or an azole, seems to be the most effective treatment. 相似文献
1000.
Viswam S. Nair Khun Visith Keu Madelyn S. Luttgen Anand Kolatkar Minal Vasanawala Ware Kuschner Kelly Bethel Andrei H. Iagaru Carl Hoh Joseph B. Shrager Billy W. Loo Jr Lyudmila Bazhenova Jorge Nieva Sanjiv S. Gambhir Peter Kuhn 《PloS one》2013,8(7)