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11.
Kamal A Shankaraiah N Prabhakar S Reddy ChR Markandeya N Reddy KL Devaiah V 《Bioorganic & medicinal chemistry letters》2008,18(7):2434-2439
A new class of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-chalcone conjugates have been prepared by employing a solid-phase synthetic protocol. In this strategy an intramolecular aza-Wittig reductive cyclization approach has been utilized. Interestingly, some of these molecules have shown enhanced DNA-binding affinity and promising anticancer activity on a large number of human cancer cell lines. 相似文献
12.
The scrambling of rhythms, i.e. their mixing-up or throwing into disorder, on a variety of schedules of lighting and feeding, left the average overall life span of several groups of mice unaffected. One particularly scrambled schedule prolonged 10th-decile survival time. The phase-shifting of rhythms, in a mammalian simulation of shift-work schedules, need not be harmful and can be indifferent or even beneficial. Such findings have important implications for health, performance and safety in human shift-work by both sexes and for the choice of other schedules, such as those for drug treatments or exercise. 相似文献