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The objective of this study was to assess whether melatonin accelerates the re-entrainment of locomotor activity after 6 h
of advance and delay phase shifts following exposure to LD 12:12 cycle (simulating jet-lag/shift work). An experimental group
of adult male field mice Mus booduga were subjected to melatonin (1 mg/kg) through i.p. and the control group were treated
with 50 % DMSO. The injections were administered on three consecutive days following 6h of phase advance and delay, at the
expected time of “lights off”. The results show that melatonin accelerates the re-entrainment after phase advance (29%) when
compared with control mice. In the 6 h phase delay study, the experimental mice (melatonin administered) take more cycles
for re-entrainment (51%) than the control. Further, the results suggest that though melatonin may be useful for the treatment
of jet-lag caused by eastward flight (phase advance) it may not be useful for westward flight (phase delay) jet-lag 相似文献
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