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91.
Ghaffari Maedeh Kalantar Seyed Mehdi Hemati Mahdie Dehghani Firoozabadi Ali Asri Amir Shams Ali Jafari Ghalekohneh Sina Haghiralsadat Fateme 《Biotechnology letters》2021,43(5):981-994
Biotechnology Letters - Tumor suppressor miRNAs, miR-15a and miR-16–1, with high-specificity and oncogenic targeting of Bcl-2, can target tumor tissues. Disadvantages of the clinical... 相似文献
92.
Nazila V. Jafari Sarah A. Kuehne Clare E. Bryant Mamoun Elawad Brendan W. Wren Nigel P. Minton Elaine Allan Mona Bajaj-Elliott 《PloS one》2013,8(7)
Clostridium difficile infection (CDI) is the leading cause of hospital and community-acquired antibiotic-associated diarrhoea and currently represents a significant health burden. Although the role and contribution of C. difficile toxins to disease pathogenesis is being increasingly understood, at present other facets of C. difficile-host interactions, in particular, bacterial-driven effects on host immunity remain less studied. Using an ex-vivo model of infection, we report that the human gastrointestinal mucosa elicits a rapid and significant cytokine response to C. difficile. Marked increase in IFN-γ with modest increase in IL-22 and IL-17A was noted. Significant increase in IL-8 suggested potential for neutrophil influx while presence of IL-12, IL-23, IL-1β and IL-6 was indicative of a cytokine milieu that may modulate subsequent T cell immunity. Majority of C. difficile-driven effects on murine bone-marrow-derived dendritic cell (BMDC) activation were toxin-independent; the toxins were however responsible for BMDC inflammasome activation. In contrast, human monocyte-derived DCs (mDCs) released IL-1β even in the absence of toxins suggesting host-specific mediation. Infected DC-T cell crosstalk revealed the ability of and 630 WT strains to elicit a differential DC IL-12 family cytokine milieu which culminated in significantly greater Th1 immunity in response to R20291. Interestingly, both strains induced a similar Th17 response. Elicitation of mucosal IFN-γ/IL-17A and Th1/Th17 immunity to C. difficile indicates a central role for this dual cytokine axis in establishing antimicrobial immunity to CDI. R20291相似文献
93.
Yanan Ren Fernanda Ferraz Abbass Jafari Kang Qiuyan Yuan 《Journal of biological engineering》2017,11(1):42
Background
Aerobic granular sludge has become an attractive alternative to the conventional activated sludge due to its high settling velocity, compact structure, and higher tolerance to toxic substances and adverse conditions. Aerobic granular sludge process has been studied intensively in the treatment of municipal and industrial wastewater. However, information on leachate treatment using aerobic granular sludge is very limited.Methods
This study investigated the treatment performance of old landfill leachate with different levels of ammonium using two aerobic sequencing batch reactors (SBR): an activated sludge SBR (ASBR) and a granular sludge SBR (GSBR). Aerobic granules were successfully developed using old leachate with low ammonium concentration (136 mg L?1 NH4 +-N).Results
The GSBR obtained a stable chemical oxygen demand (COD) removal of 70% after 15 days of operation; while the ASBR required a start-up of at least 30 days and obtained unstable COD removal varying from 38 to 70%. Ammonium concentration was gradually increased in both reactors. Increasing influent ammonium concentration to 225 mg L?1 N, the GSBR removed 73 ± 8% of COD; while COD removal of the ASBR was 59 ± 9%. The GSBR was also more efficient than the ASBR for nitrogen removal. The granular sludge could adapt to the increasing concentrations of ammonium, achieving 95 ± 7% removal efficiency at a maximum influent concentration of 465 mg L?1 N. Ammonium removal of 96 ± 5% was obtained by the ASBR when it was fed with a maximum of 217 mg L?1 NH4 +-N. However, the ASBR was partially inhibited by free-ammonia and nitrite accumulation rate increased up to 85%. Free-nitrous acid and the low biodegradability of organic carbon were likely the main factors affecting phosphorus removal.Conclusion
The results from this research suggested that aerobic granular sludge have advantage over activated sludge in leachate treatment.94.
Jafari R. Kideghesho 《Biodiversity and Conservation》2016,25(3):427-449
Wildlife crime is increasingly gaining prominence in global environmental debates. The crime, generating huge financial returns to few individuals, has far reaching implications on ecology, economy and global security. The seriousness of these implications provides sufficient rationale for reconsidering and intensifying efforts to combat this crime. However, these efforts are compromised by a number of challenges, though opportunities for success exist. This paper presents some of these challenges and opportunities available for reversing the trend of wildlife crime in Tanzania. The challenges presented include poverty, high profit associated with illicit trade on wildlife, poor governance and corruption, minimal budget and inadequate institutional support, political interference and low employee morale, minimal benefits to local communities, human population growth, climate change and HIV/AIDS pandemic. Opportunities identified include increased public awareness, growing global political concern and commitment, presence of relevant policies, programmes and strategies along with international agreements supportive to species protection. Before embarking on challenges and opportunities, the paper provides an overview of Tanzania’s wildlife resources, status and trend of this crime. In conclusion, the paper underscores the gravity of the problem and its implications and offers some recommendations for improving the situation. 相似文献
95.
Seyed Mohammad Seyedi Zeinab Jafari Neda Attaran Hamid Sadeghian Mohammad Reza Saberi Mohammad Mahdi Riazi 《Bioorganic & medicinal chemistry》2009,17(4):1614-1622
A group of 4-allyloxyaniline amides 5a–o were designed, synthesized and evaluated as potential inhibitors of soybean 15-lipoxygenase (SLO) on the basis of eugenol and esteragol structures. Compound 5e showed the best IC50 in SLO inhibition (IC50 = 0.67 ± 0.06 μM). All compounds were docked in SLO active site retrieved from RCSB Protein Data Bank (PDB entry: 1IK3) and showed that allyloxy group of compounds is oriented towards the Fe3+-OH moiety in the active site of enzyme and fixed by hydrogen bonding with two conserved His513 and Gln716. It is resulted that molecular volume of the amide moiety would be a major factor in inhibitory potency variation of the synthetic amides, where the hydrogen bonding of the amide group could also involve in the activity of the inhibitors. 相似文献
96.
It seems that seeing others in slow-motion by heroes does not belong only to movies. When Lionel Messi plays football, you can hardly see anything from him that other players cannot do. Then why he is not stoppable really? It seems the answer may be that opponents do not have enough time to do what they want; because in Messi’s neural system, time passes slower. In differential equations that model a single neuron, this speed can be generated by multiplying an equal term in all equations. Or maybe interactions between neurons and the structure of neural networks play this role. 相似文献
97.
Ehsan Faghih-Mirzaei Salehe Sabouri Leila Zeidabadinejad Salman AbdolahRamazani Mehdi Abaszadeh Arash Khodadadi Mohadeseh Shamsadinipour Mandana Jafari Somayeh Pirhadi 《Bioorganic & medicinal chemistry》2019,27(2):305-314
A series of novel metronidazole aryloxy, carboxy and azole derivatives has been synthesized and their cytotoxic activities on three cancer cell lines were evaluated by MTT assay. Compounds 4m, 4l and 4d showed the most potent cytotoxic activity (IC50s?less than?100?µg/mL). Apoptosis was also detected for these compounds by flow cytometry. Docking studies were performed in order to propose the probable target protein. In the next step, molecular dynamics simulation was carried out on the proposed target protein, focal adhesion kinase (FAK, PDB code: 2ETM), bound to compound 4m. As, 4m showed a potent cytotoxic activity and an acceptable apoptotic effect, it can be a potential anticancer candidate that may work through inhibition of FAK. 相似文献
98.
Mohsen A. Jafari 《Flexible Services and Manufacturing Journal》1992,4(2):159-181
In a dynamic and flexible manufacturing environment, a shop-floor controller must be designed so that it automatically (or with minimum human intervention) and quickly responds to the changes (e.g., in part type or part routing) in the system. Such a performance may be achieved provided that the controller is simple and sufficiently general in its scope of application. In this article, we present an architecture for such a shop-floor controller. The architecture is based on colored Petri nets with ordered colored sets and structured input and output functions. 相似文献
99.
100.
Naeimeh Tayebi 《Indian journal of human genetics》2008,14(1):23-26