全文获取类型
收费全文 | 222篇 |
免费 | 19篇 |
出版年
2023年 | 4篇 |
2022年 | 9篇 |
2021年 | 12篇 |
2020年 | 18篇 |
2019年 | 18篇 |
2018年 | 19篇 |
2017年 | 12篇 |
2016年 | 10篇 |
2015年 | 8篇 |
2014年 | 17篇 |
2013年 | 24篇 |
2012年 | 26篇 |
2011年 | 16篇 |
2010年 | 8篇 |
2009年 | 7篇 |
2008年 | 8篇 |
2007年 | 3篇 |
2006年 | 6篇 |
2005年 | 1篇 |
2004年 | 3篇 |
2003年 | 2篇 |
2002年 | 2篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1997年 | 1篇 |
1992年 | 1篇 |
1989年 | 1篇 |
1983年 | 1篇 |
1976年 | 1篇 |
排序方式: 共有241条查询结果,搜索用时 46 毫秒
71.
Assadi M Salimipour H Akbarzadeh S Nemati R Jafari SM Bargahi A Samani Z Seyedabadi M Sanjdideh Z Nabipour I 《PloS one》2011,6(9):e24240
Background
Patients with multiple sclerosis (MS) are at increased risk of osteoporosis and fractures. Adipose tissue-derived adipokines may play important roles in the osteoimmunology of MS. In order to determine whether omentin-1 and vaspin may be related to bone health in MS patients, we compared circulating levels of these recently identified adipokines, between MS patients and healthy controls.Methods
A total of 35 ambulatory MS patients with relapsing-remitting courses were compared with 38 age- and sex-matched healthy controls. Bone mineral density (BMD) was determined for the lumbar spine (L2–L4) and the proximal femur using dual-energy x-ray absorptiometry. Circulating omentin-1, vaspin, osteocalcin, osteopontin, osteoprotegerin, the receptor activator of nuclear factor-κB ligand, matrix metalloproteinase 9, C-reactive protein and 25-hydroxy vitamin D levels were evaluated by highly specific enzyme-linked immunosorbent assay methods.Results
There was no significant difference between the two groups regarding bone-related cytokines, adipocytokines, and the BMD measurements of patients with MS and the healthy controls. However, in multiple regression analysis, serum omentin-1 levels were positively correlated with BMD at the femoral neck (β = 0.49, p = 0.016), total hip (β = 0.42, p = 0.035), osteopontin (β = 0.42, p = 0.030) and osteocalcin (β = 0.53, p = 0.004) in MS patients. No correlations were found between vaspin, biochemical, and BMD measures in both groups.Conclusions
Elevated omentin-1 serum levels are correlated with BMD at the femoral neck and the serum levels of osteocalcin and osteopontin in MS patients. Therefore, there is crosstalk between adipose tissue and bone in MS. 相似文献72.
Moustafa Algamal Julijana Milojevic Naeimeh Jafari William Zhang Giuseppe Melacini 《Biophysical journal》2013
Human serum albumin (HSA) is a potent inhibitor of Aβ self-association and this novel, to our knowledge, function of HSA is of potential therapeutic interest for the treatment of Alzheimer’s disease. It is known that HSA interacts with Aβ oligomers through binding sites evenly partitioned across the three albumin domains and with comparable affinities. However, as of this writing, no information is available on the HSA-Aβ interactions beyond domain resolution. Here, we map the HSA-Aβ interactions at subdomain and peptide resolution. We show that each separate subdomain of HSA domain 3 inhibits Aβ self-association. We also show that fatty acids (FAs) compete with Aβ oligomers for binding to domain 3, but the determinant of the HSA/Aβ oligomer interactions are markedly distinct from those of FAs. Although salt bridges with the FA carboxylate determine the FA binding affinities, hydrophobic contacts are pivotal for Aβ oligomer recognition. Specifically, we identified a site of Aβ oligomer recognition that spans the HSA (494–515) region and aligns with the central hydrophobic core of Aβ. The HSA (495–515) segment includes residues affected by FA binding and this segment is prone to self-associate into β-amyloids, suggesting that sites involved in fibrilization may provide a lead to develop inhibitors of Aβ self-association. 相似文献
73.
74.
Plasmonics - In this paper, a graphene-based patch antenna is proposed. The antenna structure is designed so that each of the various antenna sections affected by chemical potential changes can... 相似文献
75.
Nazila V. Jafari Sarah A. Kuehne Clare E. Bryant Mamoun Elawad Brendan W. Wren Nigel P. Minton Elaine Allan Mona Bajaj-Elliott 《PloS one》2013,8(7)
Clostridium difficile infection (CDI) is the leading cause of hospital and community-acquired antibiotic-associated diarrhoea and currently represents a significant health burden. Although the role and contribution of C. difficile toxins to disease pathogenesis is being increasingly understood, at present other facets of C. difficile-host interactions, in particular, bacterial-driven effects on host immunity remain less studied. Using an ex-vivo model of infection, we report that the human gastrointestinal mucosa elicits a rapid and significant cytokine response to C. difficile. Marked increase in IFN-γ with modest increase in IL-22 and IL-17A was noted. Significant increase in IL-8 suggested potential for neutrophil influx while presence of IL-12, IL-23, IL-1β and IL-6 was indicative of a cytokine milieu that may modulate subsequent T cell immunity. Majority of C. difficile-driven effects on murine bone-marrow-derived dendritic cell (BMDC) activation were toxin-independent; the toxins were however responsible for BMDC inflammasome activation. In contrast, human monocyte-derived DCs (mDCs) released IL-1β even in the absence of toxins suggesting host-specific mediation. Infected DC-T cell crosstalk revealed the ability of and 630 WT strains to elicit a differential DC IL-12 family cytokine milieu which culminated in significantly greater Th1 immunity in response to R20291. Interestingly, both strains induced a similar Th17 response. Elicitation of mucosal IFN-γ/IL-17A and Th1/Th17 immunity to C. difficile indicates a central role for this dual cytokine axis in establishing antimicrobial immunity to CDI. R20291相似文献
76.
Farnoush Jafari Iri-Sofla Fatemeh Rahbarizadeh Davoud Ahmadvand Mohammad J. Rasaee 《Experimental cell research》2011,317(18):2630
The crucial role of T lymphocytes in anti-tumor immunity has led to the development of novel strategies that can target and activate T cells against tumor cells. Recombinant DNA technology has been used to generate non-MHC-restricted chimeric antigen receptors (CARs). Here, we constructed a panel of recombinant CAR that harbors the anti-MUC1 nanobody and the signaling and co-signaling moieties (CD3ζ/CD28) with different spacer regions derived from human IgG3 with one or two repeats of the hinge sequence or the hinge region of FcγRII. The PhiC31 integrase system was employed to investigate if the recombination efficiency could be recruited for high and stable expression of T cell chimeric receptor genes. The effect of nuclear localization signal (NLS) and two different promoters (CMV and CAG) on efficacy of PhiC31 integrase in human T cell lines was evaluated. The presence of integrase in combination with NLS, mediated up to 7.6 and 8.5 fold increases in CAR expression in ZCHN-attB and ZCHHN-attB cassette integrated T cells, respectively. Our results showed that highly efficient and stable transduction of the Jurkat cell line by PhiC31 integrase is a feasible modality for generating anti-cancer chimeric T cells for use in cancer immunotherapy. 相似文献
77.
R. Patimar E. Ownagh N. Jafari M. Hosseini 《Zeitschrift fur angewandte Ichthyologie》2009,25(6):776-778
It is believed that streams of a basin may contribute to stream‐specific variation in allometry coefficients related to between‐habitat differences. To test intra‐basin variation of the allometry coefficients of Lenkorn Capoeta capoeta gracilis (Keyserling, 1861), a total of 1731 individuals were sampled in six streams of the Gorganroud basin (southeast Caspian Sea) between April and May 2008. Values of b ranged from 2.647 for males of Chelchai to 2.964 for females of Madarsou, indicating negative allometric growth for the fish in the basin. There were variations in the allometry coefficient among the considered groups, which can be interpreted as species’ response to different habitats. To the best knowledge of the authors, this study documents the comparative reference on variation of allometry coefficient of Capoeta capoeta gracilis in southeast Caspian streams. 相似文献
78.
Jafari Marjan Shiran Behrouz Rabiei Gholamreza Ravash Rudabeh Sayed Tabatabaei Badraldin Ebrahim Martínez-García Pedro J. Martínez-Gómez Pedro 《Plant Growth Regulation》2022,97(2):357-373
Plant Growth Regulation - Almond is a stone fruit crop belonging to the Rosaceae family, cultivated in the temperate region of the world for its high nutritive valued fruits. In today’s... 相似文献
79.
Jafari Marziyeh Shahsavar Ali Reza 《In vitro cellular & developmental biology. Plant》2022,58(1):155-168
In Vitro Cellular & Developmental Biology - Plant - As a novel antioxidant, sodium nitroprusside (SNP) can be used to reduce the adverse effects of various abiotic stresses, especially drought... 相似文献
80.
Javid Sadri Nahand Sima Taghizadeh-boroujeni Mohammad Karimzadeh Sarina Borran Mohammad Hossein Pourhanifeh Mohsen Moghoofei Farah Bokharaei-Salim Sajad Karampoor Amir Jafari Zatollah Asemi Alireza Tbibzadeh Afshin Namdar Hamed Mirzaei 《Journal of cellular physiology》2019,234(10):17064-17099
Cervical cancer is as a kind of cancer beginning from the cervix. Given that cervical cancer could be observed in women who infected with papillomavirus, regular oral contraceptives, and multiple pregnancies. Early detection of cervical cancer is one of the most important aspects of the therapy of this malignancy. Despite several efforts, finding and developing new biomarkers for cervical cancer diagnosis are required. Among various prognostic, diagnostic, and therapeutic biomarkers, miRNA have been emerged as powerful biomarkers for detection, treatment, and monitoring of response to therapy in cervical cancer. Here, we summarized various miRNAs as an employable platform for prognostic, diagnostic, and therapeutic biomarkers in the treatment of cervical cancer. 相似文献