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81.
Benedikt Junglas Stefan T. Huber Thomas Heidler Lukas Schlösser Daniel Mann Raoul Hennig Mairi Clarke Nadja Hellmann Dirk Schneider Carsten Sachse 《Cell》2021,184(14):3674-3688.e18
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82.
Luisa Azambuja Alcalde Betânia Souza de Freitas Gustavo Dalto Barroso Machado Pedro Castilhos de Freitas Crivelaro Victoria Campos Dornelles Henrique Gus Ricardo Tavares Monteiro Luiza Wilges Kist Mauricio Reis Bogo Nadja Schröder 《Biometals》2018,31(6):927-940
Brain-derived neurotrophic factor (BDNF) plays a key role in neural development and physiology, as well as in pathological states. Post-mortem studies demonstrate that BDNF is reduced in the brains of patients affected by neurodegenerative diseases. Iron accumulation has also been associated to the pathogenesis of neurodegenerative diseases. In rats, iron overload induces persistent memory deficits, increases oxidative stress and apoptotic markers, and decreases the expression of the synaptic marker, synaptophysin. Deferiprone (DFP) is an oral iron chelator used for the treatment of systemic iron overload disorders, and has recently been tested for Parkinson’s disease. Here, we investigated the effects of iron overload on BDNF levels and on mRNA expression of genes encoding TrkB, p75NTR, catalase (CAT) and NQO1. We also aimed at investigating the effects of DFP on iron-induced impairments. Rats received iron or vehicle at postnatal days 12–14 and when adults, received chronic DFP or water (vehicle). Recognition memory was tested 19 days after the beginning of chelation therapy. BDNF measurements and expression analyses in the hippocampus were performed 24 h after the last day of DFP treatment. DFP restored memory and increased hippocampal BDNF levels, ameliorating iron-induced effects. Iron overload in the neonatal period reduced, while treatment with DFP was able to rescue, the expression of antioxidant enzymes CAT and NQO1. 相似文献
83.
84.
Elizabeth A. Stiles Nadja B. Cech Stacy M. Dee Elizabeth P. Lacey 《Physiologia plantarum》2007,129(4):756-765
Flower color in the weedy perennial Plantago lanceolata is phenotypically plastic. Darker flowers are produced at cooler ambient temperatures, and circumstantial evidence suggests that this is adaptive. The goal of this project was to investigate the chemical basis for the color plasticity. To test the hypothesis that increased anthocyanin production at low temperatures underlies the plasticity, extracts of P. lanceolata flowers produced at warm and cool temperatures were analyzed using UV/visible spectrophotometry coupled with mass spectrometry. Mass spectrometry allowed us to compare relative abundances of individual anthocyanins. Seventeen anthocyanins, derived from both cyanidin and delphinidin branches of the anthocyanin biosynthetic pathway, were detected. Most of these significantly increased in abundance under cool conditions. Genotypes differed significantly in anthocyanin levels and in their sensitivity to temperature change. Genotypes that showed greater floral color plasticity tended to show also greater temperature sensitivity with respect to anthocyanin production. Data suggest that the temperature regulation of the anthocyanin biosynthetic pathway occurs both upstream and downstream of the divergence of the cyanidin and delphinidin branches. The degree of temperature sensitivity, i.e. phenotypic plasticity, appears to be controlled downstream, whereas the overall temperature effect appears to be controlled upstream. 相似文献
85.
In the past 70 years radar technology has been increasingly applied in ornithological research in various geographical areas worldwide and has contributed greatly to a better understanding of bird migration. Many different radar types have been used, such as tracking, ship or weather radars. However, radar wind profilers (RWPs) have been largely neglected in avian research. RWPs continuously measure three‐dimensional winds and, despite the low frequency range at which these systems operate, available literature provides evidence that birds are recorded at many sites. So far the potential of RWPs in ornithological research has not been fully explored and studies deal predominantly with birds in the context of clutter removal. However, based on their broad implementation in networks (e.g. E‐PROFILE in Europe) situated in areas that are strategically important for bird migration, they could offer a valuable complement to already established or planned large‐scale bird monitoring schemes by radar. The objective of this paper is to serve as a reference for those who wish to consider RWP data in a biological context. To that end, we provide an overview of the evolution and establishment of operational RWPs as well as of their mode of operation, in order to depict their role in meteorology and to evaluate their potential in ornithology. The assessment is based on available literature on RWPs and radar ornithology outlining the past, present and potential future role of wind profilers. In the past, birds were discarded as contamination and eliminated as far as possible from the meteorological data. Only recently have the echo signatures of biological targets been scrutinized thoroughly in raw data and used successfully for ornithological investigation. On this basis it is possible to consider the potential future utility of this promising data source as a complement to other remote‐sensing instruments and other sampling techniques used in avian research. Weather independence of ornithological information was found to be a particular benefit. However, as the development of the bird‐specific method is only in an early stage, more detailed studies are necessary in the future to fully assess the potential of this type of radar. 相似文献
86.
Nadja Lepsch-Cunha Paulo Y. Kageyama Roland Vencovsky 《Biodiversity and Conservation》1999,8(9):1205-1218
We quantified the within-population genetic variation of Couratari multiflora and C. guianensis, two tree species found in terra firme forests of central Amazonia. Both species have some ecological features in common, but they differ in population abundance across their geographic ranges. While C. multiflora has been found only in low-density populations in all sites studied to date, C. guianensis is relatively common in some sites and very scarce in others. In a 400-ha plot, we found 41 and 29 adults of C. multiflora and C. guianensis, respectively. Twenty-two saplings of C. guianensis and 103 seedlings of C. multiflora were also examined. The mean expected heterozygosities (Hem) of seedlings and adults of C. multiflora were 0.431 and 0.436, and the mean fixation indices (Fm), 0.114 and 0.176, respectively. For C. guianensis, saplings and adults presented Hem equal to 0.425 and 0.429, and the Fm were 0.393 and 0.527, respectively. These low-density populations of two congeneric species did not differ in terms of genetic diversity, but rather they differed in terms of mean observed heterozygosity (Hom), and therefore Fm. The species with variable population density had lower Hom and greater Fm relative to the species that is always found in low-density. 相似文献
87.
Pradeep S. Chauhan Kevin Chen Ramandeep K. Babbra Wenjia Feng Nadja Pejovic Armaan Nallicheri Peter K. Harris Katherine Dienstbach Andrew Atkocius Lenon Maguire Faridi Qaium Jeffrey J. Szymanski Brian C. Baumann Li Ding Dengfeng Cao Melissa A. Reimers Eric H. Kim Zachary L. Smith Vivek K. Arora Aadel A. Chaudhuri 《PLoS medicine》2021,18(12)
88.
The endothelial glycocalyx (EG) is a complex biopolymer network produced by vascular endothelial cells that forms a layer with multiple functions at the luminal side of blood vessels. The EG acts as an anti-adhesive protection layer, as a molecular sieve, as a chemical sensor site, and as a mechanotransducer of fluid shear stress to the underlying cell layer. A major component involved in these processes is the highly hydrated glycosaminoglycan (GAG) hyaluronan (HA). Here we used laser interferometry to measure the broadband mechanical response of reconstituted HA solutions at close to physiological conditions. HA showed rheological behavior consistent with that of a flexible polymer. The elastic behavior observed for entangled HA networks showed reptational relaxation with a large distribution of time scales, which disappeared quickly (15 min) with the addition of hyaluronidase (HAase). We conclude that the broadband mechanical probing of model systems (HA solutions) provides quantitative data that are crucial to understand the mechanical response of the EG in vivo and its role in mechanosensing. 相似文献
89.
Nadja Kabelitz Jirina Machackova Gwenaël Imfeld Maria Brennerova Dietmar H. Pieper Hermann J. Heipieper Howard Junca 《Applied microbiology and biotechnology》2009,82(3):565-577
In order to obtain insights in complexity shifts taking place in natural microbial communities under strong selective pressure,
soils from a former air force base in the Czech Republic, highly contaminated with jet fuel and at different stages of a bioremediation
air sparging treatment, were analyzed. By tracking phospholipid fatty acids and 16S rRNA genes, a detailed monitoring of the
changes in quantities and composition of the microbial communities developed at different stages of the bioventing treatment
progress was performed. Depending on the length of the air sparging treatment that led to a significant reduction in the contamination
level, we observed a clear shift in the soil microbial community being dominated by Pseudomonads under the harsh conditions
of high aromatic contamination to a status of low aromatic concentrations, increased biomass content, and a complex composition
with diverse bacterial taxonomical branches.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users.
The online version of an erratum to this article can be found at http://dx.doi.org/.
An erratum to this article can be found at 相似文献
90.
Nicola Di Maiuta Silvia Hubschmid Nadja Giuliani Patrick Schwarzentruber Crawford S. Dow 《International biodeterioration & biodegradation》2009,63(6):769-777
Two different formaldehyde-degrading microorganisms, Pseudomonas putida and Methylobacterium extorquens, were isolated from calcium carbonate slurry containing the formaldehyde-releasing biocide (ethylenedioxy) dimethanol. Their relative formaldehyde biodegradation and formic acid production kinetics were studied in broth and in calcium carbonate slurry for each microorganism individually, as well as in mixed cultures. Furthermore, the minimal inhibition concentration (MIC) was determined. The results indicated that in slurry, M. extorquens is more tolerant of formaldehyde than P. putida. In slurry, microbial-induced oxidation of formaldehyde caused a temporary accumulation of formic acid, which is presumed to be responsible for pH drop and destabilisation of the calcium carbonate slurry suspension systems. In addition, the residual formaldehyde concentration was observed to drive dominance and recovery of individual formaldehyde-resistant microorganisms in the slurry. Overall, this investigation indicated that biodegradation of formaldehyde in calcium carbonate slurry is brought about by alternating dominance of bacterial genera of mixed formaldehyde-resistant microbial populations. 相似文献