全文获取类型
收费全文 | 2383篇 |
免费 | 131篇 |
国内免费 | 3篇 |
出版年
2024年 | 1篇 |
2023年 | 17篇 |
2022年 | 28篇 |
2021年 | 79篇 |
2020年 | 36篇 |
2019年 | 58篇 |
2018年 | 51篇 |
2017年 | 49篇 |
2016年 | 68篇 |
2015年 | 119篇 |
2014年 | 136篇 |
2013年 | 209篇 |
2012年 | 239篇 |
2011年 | 198篇 |
2010年 | 131篇 |
2009年 | 123篇 |
2008年 | 133篇 |
2007年 | 173篇 |
2006年 | 123篇 |
2005年 | 122篇 |
2004年 | 114篇 |
2003年 | 90篇 |
2002年 | 73篇 |
2001年 | 13篇 |
2000年 | 13篇 |
1999年 | 9篇 |
1998年 | 17篇 |
1997年 | 11篇 |
1996年 | 16篇 |
1995年 | 12篇 |
1994年 | 10篇 |
1993年 | 5篇 |
1992年 | 3篇 |
1991年 | 6篇 |
1990年 | 1篇 |
1989年 | 3篇 |
1988年 | 2篇 |
1987年 | 4篇 |
1986年 | 2篇 |
1984年 | 4篇 |
1983年 | 1篇 |
1982年 | 3篇 |
1981年 | 1篇 |
1979年 | 3篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1974年 | 1篇 |
1970年 | 2篇 |
1967年 | 2篇 |
1956年 | 1篇 |
排序方式: 共有2517条查询结果,搜索用时 15 毫秒
81.
Clinical,genetic and neuropathological findings in a series of 138 fetuses with a corpus callosum malformation
下载免费PDF全文
![点击此处可从《Birth defects research. Part A, Clinical and molecular teratology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Caroline Alby Valérie Malan Lucile Boutaud Maria Angela Marangoni Bettina Bessières Maryse Bonniere Amale Ichkou Nadia Elkhartoufi Nadia Bahi‐Buisson Pascale Sonigo Anne‐Elodie Millischer Sophie Thomas Yves Ville Michel Vekemans Férechté Encha‐Razavi Tania Attié‐Bitach 《Birth defects research. Part A, Clinical and molecular teratology》2016,106(1):36-46
82.
Francesca Ascenzi Laura Barberi Gabriella Dobrowolny Aline Villa Nova Bacurau Carmine Nicoletti Emanuele Rizzuto Nadia Rosenthal Bianca Maria Scicchitano Antonio Musar 《Aging cell》2019,18(3)
The decline in skeletal muscle mass and strength occurring in aging, referred as sarcopenia, is the result of many factors including an imbalance between protein synthesis and degradation, changes in metabolic/hormonal status, and in circulating levels of inflammatory mediators. Thus, factors that increase muscle mass and promote anabolic pathways might be of therapeutic benefit to counteract sarcopenia. Among these, the insulin‐like growth factor‐1 (IGF‐1) has been implicated in many anabolic pathways in skeletal muscle. IGF‐1 exists in different isoforms that might exert different role in skeletal muscle. Here we study the effects of two full propeptides IGF‐1Ea and IGF‐1Eb in skeletal muscle, with the aim to define whether and through which mechanisms their overexpression impacts muscle aging. We report that only IGF‐1Ea expression promotes a pronounced hypertrophic phenotype in young mice, which is maintained in aged mice. Nevertheless, examination of aged transgenic mice revealed that the local expression of either IGF‐1Ea or IGF‐1Eb transgenes was protective against age‐related loss of muscle mass and force. At molecular level, both isoforms activate the autophagy/lysosome system, normally altered during aging, and increase PGC1‐α expression, modulating mitochondrial function, ROS detoxification, and the basal inflammatory state occurring at old age. Moreover, morphological integrity of neuromuscular junctions was maintained and preserved in both MLC/IGF‐1Ea and MLC/IGF‐1Eb mice during aging. These data suggest that IGF‐1 is a promising therapeutic agent in staving off advancing muscle weakness. 相似文献
83.
Nadia I. Maaroufi Annika Nordin Kristin Palmqvist Niles J. Hasselquist Benjamin Forsmark Nicholas P. Rosenstock Hkan Wallander Michael J. Gundale 《Global Change Biology》2019,25(9):2900-2914
There is evidence that anthropogenic nitrogen (N) deposition enhances carbon (C) sequestration in boreal forest soils. However, it is unclear how free‐living saprotrophs (bacteria and fungi, SAP) and ectomycorrhizal (EM) fungi responses to N addition impact soil C dynamics. Our aim was to investigate how SAP and EM communities are impacted by N enrichment and to estimate whether these changes influence decay of litter and humus. We conducted a long‐term experiment in northern Sweden, maintained since 2004, consisting of ambient, low N additions (0, 3, 6, and 12 kg N ha?1 year?1) simulating current N deposition rates in the boreal region, as well as a high N addition (50 kg N ha?1 year?1). Our data showed that long‐term N enrichment impeded mass loss of litter, but not of humus, and only in response to the highest N addition treatment. Furthermore, our data showed that EM fungi reduced the mass of N and P in both substrates during the incubation period compared to when only SAP organisms were present. Low N additions had no effect on microbial community structure, while the high N addition decreased fungal and bacterial biomasses and altered EM fungi and SAP community composition. Actinomycetes were the only bacterial SAP to show increased biomass in response to the highest N addition. These results provide a mechanistic understanding of how anthropogenic N enrichment can influence soil C accumulation rates and suggest that current N deposition rates in the boreal region (≤12 kg N ha?1 year?1) are likely to have a minor impact on the soil microbial community and the decomposition of humus and litter. 相似文献
84.
Nadia Formicola Jeshlee Vijayakumar Florence Besse 《Traffic (Copenhagen, Denmark)》2019,20(9):639-649
Membrane‐less organelles, because of their capacity to dynamically, selectively and reversibly concentrate molecules, are very well adapted for local information processing and rapid response to environmental fluctuations. These features are particularly important in the context of neuronal cells, where synapse‐specific activation, or localized extracellular cues, induce signaling events restricted to specialized axonal or dendritic subcompartments. Neuronal ribonucleoprotein (RNP) particles, or granules, are nonmembrane bound macromolecular condensates that concentrate specific sets of mRNAs and regulatory proteins, promoting their long‐distance transport to axons or dendrites. Neuronal RNP granules also have a dual function in regulating the translation of associated mRNAs: while preventing mRNA translation at rest, they fuel local protein synthesis upon activation. As revealed by recent work, rapid and reversible switches between these two functional modes are triggered by modifications of the networks of interactions underlying RNP granule assembly. Such flexible properties also come with a cost, as neuronal RNP granules are prone to transition into pathological aggregates in response to mutations, aging, or cellular stresses, further emphasizing the need to better understand the mechanistic principles governing their dynamic assembly and regulation in living systems. 相似文献
85.
Santini Nadia S. Lovelock Catherine E. Hua Quan Zawadzki Atun Mazumder Debashish Mercer Tim R. Muñoz-Rojas Miriam Hardwick Simon A. Madala Bindu Swapna Cornwell William Thomas Torsten Marzinelli Ezequiel M. Adam Paul Paul Swapan Vergés Adriana 《Ecosystems》2019,22(8):1803-1822
Ecosystems - Saltmarshes provide many valuable ecosystem services including storage of a large amount of ‘blue carbon’ within their soils. To date, up to 50% of the world’s... 相似文献
86.
87.
Bastian Mechsner Dietrich Böse Fabian Hogenkamp Nadia Ledermann Rudolf Hartmann Kevin Bochinsky Wolfgang Frey Jörg Pietruszka 《Bioorganic & medicinal chemistry》2019,27(13):2991-2997
The development of the first enantioselective total synthesis of altersolanol N is reported. The decisive step of the synthesis is the enantioselective formation of the tetrahydroanthraquinone nucleus by a [4 + 2]-cycloaddition in high yield and with excellent diastereo- and enantioselectivity (>95:5 dr and 95:5 er). In addition, a demanding selective monoacetylation of the OH group at the C-2 position was achieved: an epoxide ring opening with the participation of a neighbouring acetyl group could be established. The route proved to be an efficient alternative to also access enantiomerically pure altersolanol A. 相似文献
88.
89.
Nadia Urbain Nicolas Fourcaud-Trocmé Samuel Laheux Paul A. Salin Luc J. Gentet 《Cell reports》2019,26(6):1443-1457.e5