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21.
Myneni SR Settem RP Connell TD Keegan AD Gaffen SL Sharma A 《Journal of immunology (Baltimore, Md. : 1950)》2011,187(1):501-509
Periodontal disease (PD) is a chronic inflammation of the tooth-supporting soft tissue and alveolar bone due to infection by a select group of gram-negative microbes, which leads to tooth loss if untreated. Because mice deficient in CD4(+) cells are resistant to infection-induced alveolar bone loss, Th cells have been implicated in bone-destructive processes during PD. However, the extent to which different Th cell subtypes play roles in pathogenesis or host protection remains to be defined and is likely to vary depending on the dominant microorganism involved. By far, Porphyromonas gingivalis is the best-studied periodontal microbe in PD. Although the gram-negative anaerobe Tannerella forsythia is also a vital contributor to periodontal bone loss, almost nothing is known about immune responses to this organism. Previous studies from our laboratory revealed that T. forsythia induces periodontal bone loss in mice and that this bone loss depends on the bacterially expressed BspA protein. In this study, we showed that T. forsythia activates murine APCs primarily through TLR2-dependent signaling via BspA. Furthermore, T. forsythia infection causes a pronounced Th2 bias, evidenced by T cell expression of IL-5, but not IFN-γ or IL-17, in draining lymph nodes. Consistently, deficiencies in TLR2 or STAT6 result in resistance to T. forsythia-induced alveolar bone loss. Thus, TLR2 signaling and Th2 cells play pathogenic roles in T. forsythia-induced alveolar bone destruction. 相似文献
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Higher northern latitude normalized difference vegetation index and growing season trends from 1982 to 1999 总被引:14,自引:0,他引:14
C. J. Tucker D. A. Slayback J. E. Pinzon S. O. Los R. B. Myneni M. G. Taylor 《International journal of biometeorology》2001,45(4):184-190
Normalized difference vegetation index data from the polar-orbiting National Oceanic and Atmospheric Administration meteorological
satellites from 1982 to 1999 show significant variations in photosynthetic activity and growing season length at latitudes
above 35°N. Two distinct periods of increasing plant growth are apparent: 1982–1991 and 1992–1999, separated by a reduction
from 1991 to 1992 associated with global cooling resulting from the volcanic eruption of Mt. Pinatubo in June 1991. The average
May to September normalized difference vegetation index from 45°N to 75°N increased by 9% from 1982 to 1991, decreased by
5% from 1991 to 1992, and increased by 8% from 1992 to 1999. Variations in the normalized difference vegetation index were
associated with variations in the start of the growing season of –5.6, +3.9, and –1.7 days respectively, for the three time
periods. Our results support surface temperature increases within the same period at higher northern latitudes where temperature
limits plant growth.
Received: 25 October 2000 / Revised: 20 August 2001 / Accepted: 22 August 2001 相似文献
25.
Jean-Philippe Bellenger Françoise Arnaud-Neu Zouhair Asfari Satish C. B. Myneni Edward I. Stiefel Anne M. L. Kraepiel 《Journal of biological inorganic chemistry》2007,12(3):367-376
Azotochelin is a biscatecholate siderophore produced by the nitrogen-fixing soil bacterium Azotobacter vinelandii. The complexation properties of azotochelin with a series of oxoanions [Mo(VI), W(VI) and V(V)] and divalent cations [Cu(II),
Zn(II), Co(II) and Mn(II)] were investigated by potentiometry, UV–vis and X-ray spectroscopy. Azotochelin forms a strong 1:1
complex with molybdate (log K = 7.6 ± 0.4) and with tungstate and vanadate; the stability of the complexes increases in the order Mo < V < W (log K
appMo = 7.3 ± 0.4; log K
appV = 8.8 ± 0.4 and log K
appW = 9.0 ± 0.4 at pH 6.6). The Mo atom in the 1:1 Mo–azotochelin complex is bound to two oxo groups in a cis position and to the two catecholate groups of azotochelin, resulting in a slightly distorted octahedral configuration. Below
pH 5, azotochelin appears to form polynuclear complexes with Mo in addition to the 1:1 complex. Azotochelin also forms strong
complexes with divalent metals. Of the metals studied, Cu(II) binds most strongly to azotochelin , followed by Zn(II) , Mn(II) and Co(II) . Since very few organic ligands are known to bind strongly to oxoanions (and particularly molybdate) at circumneutral pH,
the unusual properties of azotochelin may be used for the separation and concentration of oxoanions in the laboratory and
in the field. In addition, azotochelin may prove useful for the investigation of the biogeochemistry of Mo, W and V in aquatic
and terrestrial systems.
Electronic supplementary material Supplementary material is available in the online version of this article at and is accessible for authorized users. 相似文献
26.
Inconsistencies of interannual variability and trends in long‐term satellite leaf area index products
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Chongya Jiang Youngryel Ryu Hongliang Fang Ranga Myneni Martin Claverie Zaichun Zhu 《Global Change Biology》2017,23(10):4133-4146
Understanding the long‐term performance of global satellite leaf area index (LAI) products is important for global change research. However, few effort has been devoted to evaluating the long‐term time‐series consistencies of LAI products. This study compared four long‐term LAI products (GLASS, GLOBMAP, LAI3g, and TCDR) in terms of trends, interannual variabilities, and uncertainty variations from 1982 through 2011. This study also used four ancillary LAI products (GEOV1, MERIS, MODIS C5, and MODIS C6) from 2003 through 2011 to help clarify the performances of the four long‐term LAI products. In general, there were marked discrepancies between the four long‐term LAI products. During the pre‐MODIS period (1982–1999), both linear trends and interannual variabilities of global mean LAI followed the order GLASS>LAI3g>TCDR>GLOBMAP. The GLASS linear trend and interannual variability were almost 4.5 times those of GLOBMAP. During the overlap period (2003–2011), GLASS and GLOBMAP exhibited a decreasing trend, TCDR no trend, and LAI3g an increasing trend. GEOV1, MERIS, and MODIS C6 also exhibited an increasing trend, but to a much smaller extent than that from LAI3g. During both periods, the R2 of detrended anomalies between the four long‐term LAI products was smaller than 0.4 for most regions. Interannual variabilities of the four long‐term LAI products were considerably different over the two periods, and the differences followed the order GLASS>LAI3g>TCDR>GLOBMAP. Uncertainty variations quantified by a collocation error model followed the same order. Our results indicate that the four long‐term LAI products were neither intraconsistent over time nor interconsistent with each other. These inconsistencies may be due to NOAA satellite orbit changes and MODIS sensor degradation. Caution should be used in the interpretation of global changes derived from the four long‐term LAI products. 相似文献
27.
Identification of a unique TLR2-interacting peptide motif in a microbial leucine-rich repeat protein
Myneni SR Settem RP Sojar HT Malone JP Loimaranta V Nakajima T Sharma A 《Biochemical and biophysical research communications》2012,423(3):577-582
Pathogenesis of many bacterially-induced inflammatory diseases is driven by Toll-like receptor (TLR) mediated immune responses following recognition of bacterial factors by different TLRs. Periodontitis is a chronic inflammation of the tooth supporting apparatus often leading to tooth loss, and is caused by a Gram-negative bacterial consortium that includes Tannerella forsythia. This bacterium expresses a virulence factor, the BspA, which drives periodontal inflammation by activating TLR2. The N-terminal portion of the BspA protein comprises a leucine-rich repeat (LRR) domain previously shown to be involved in the binding and activation of TLR2. The objective of the current study was to identify specific epitopes in the LRR domain of BspA that interact with TLR2. Our results demonstrate that a sequence motif GC(S/T)GLXSIT is involved in mediating the interaction of BspA with TLR2. Thus, our study has identified a peptide motif that mediates the binding of a bacterial protein to TLR2 and highlights the promiscuous nature of TLR2 with respect to ligand binding. This work could provide a structural basis for designing peptidomimetics to modulate the activity of TLR2 in order to block bacterially-induced inflammation. 相似文献
28.
Philip C. Reid Renata E. Hari Grégory Beaugrand David M. Livingstone Christoph Marty Dietmar Straile Jonathan Barichivich Eric Goberville Rita Adrian Yasuyuki Aono Ross Brown James Foster Pavel Groisman Pierre Hélaouët Huang‐Hsiung Hsu Richard Kirby Jeff Knight Alexandra Kraberg Jianping Li Tzu‐Ting Lo Ranga B. Myneni Ryan P. North J. Alan Pounds Tim Sparks René Stübi Yongjun Tian Karen H. Wiltshire Dong Xiao Zaichun Zhu 《Global Change Biology》2016,22(2):682-703
Despite evidence from a number of Earth systems that abrupt temporal changes known as regime shifts are important, their nature, scale and mechanisms remain poorly documented and understood. Applying principal component analysis, change‐point analysis and a sequential t‐test analysis of regime shifts to 72 time series, we confirm that the 1980s regime shift represented a major change in the Earth's biophysical systems from the upper atmosphere to the depths of the ocean and from the Arctic to the Antarctic, and occurred at slightly different times around the world. Using historical climate model simulations from the Coupled Model Intercomparison Project Phase 5 (CMIP5) and statistical modelling of historical temperatures, we then demonstrate that this event was triggered by rapid global warming from anthropogenic plus natural forcing, the latter associated with the recovery from the El Chichón volcanic eruption. The shift in temperature that occurred at this time is hypothesized as the main forcing for a cascade of abrupt environmental changes. Within the context of the last century or more, the 1980s event was unique in terms of its global scope and scale; our observed consequences imply that if unavoidable natural events such as major volcanic eruptions interact with anthropogenic warming unforeseen multiplier effects may occur. 相似文献
29.
Taejin Park Chi Chen Marc Macias‐Fauria Hans Tmmervik Sungho Choi Alexander Winkler Uma S. Bhatt Donald A. Walker Shilong Piao Victor Brovkin Ramakrishna R. Nemani Ranga B. Myneni 《Global Change Biology》2019,25(7):2382-2395
Seasonality in photosynthetic activity is a critical component of seasonal carbon, water, and energy cycles in the Earth system. This characteristic is a consequence of plant's adaptive evolutionary processes to a given set of environmental conditions. Changing climate in northern lands (>30°N) alters the state of climatic constraints on plant growth, and therefore, changes in the seasonality and carbon accumulation are anticipated. However, how photosynthetic seasonality evolved to its current state, and what role climatic constraints and their variability played in this process and ultimately in carbon cycle is still poorly understood due to its complexity. Here, we take the “laws of minimum” as a basis and introduce a new framework where the timing (day of year) of peak photosynthetic activity (DOYPmax) acts as a proxy for plant's adaptive state to climatic constraints on its growth. Our analyses confirm that spatial variations in DOYPmax reflect spatial gradients in climatic constraints as well as seasonal maximum and total productivity. We find a widespread warming‐induced advance in DOYPmax (?1.66 ± 0.30 days/decade, p < 0.001) across northern lands, indicating a spatiotemporal dynamism of climatic constraints to plant growth. We show that the observed changes in DOYPmax are associated with an increase in total gross primary productivity through enhanced carbon assimilation early in the growing season, which leads to an earlier phase shift in land‐atmosphere carbon fluxes and an increase in their amplitude. Such changes are expected to continue in the future based on our analysis of earth system model projections. Our study provides a simplified, yet realistic framework based on first principles for the complex mechanisms by which various climatic factors constrain plant growth in northern ecosystems. 相似文献
30.
Overexpression and Characterization of an Iron Storage and DNA-Binding Dps Protein from Trichodesmium erythraeum
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M. Castruita M. Saito P. C. Schottel L. A. Elmegreen S. Myneni E. I. Stiefel F. M. M. Morel 《Applied microbiology》2006,72(4):2918-2924
Although the role of iron in marine productivity has received a great deal of attention, no iron storage protein has been isolated from a marine microorganism previously. We describe an Fe-binding protein belonging to the Dps family (DNA binding protein from starved cells) in the N2-fixing marine cyanobacterium Trichodesmium erythraeum. A dps gene encoding a protein with significant levels of identity to members of the Dps family was identified in the genome of T. erythraeum. This gene codes for a putative DpsT. erythraeurm protein (Dpstery) with 69% primary amino acid sequence similarity to Synechococcus DpsA. We expressed and purified Dpstery, and we found that Dpstery, like other Dps proteins, is able to bind Fe and DNA and protect DNA from degradation by DNase. We also found that Dpstery binds phosphate, like other ferritin family proteins. Fe K near-edge X-ray absorption of Dpstery indicated that it has an iron core that resembles that of horse spleen ferritin. 相似文献