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51.
Sohel Md Mahmodul Hasan Akyuz Bilal Konca Yusuf Arslan Korhan Gurbulak Kutlay Abay Murat Kaliber Mahmut Cinar Mehmet Ulas 《Mammalian genome》2020,31(9-12):309-324
Mammalian Genome - Maternal nutrition during pregnancy is one of the major intrauterine environmental factors that influence fetal development by significantly altering the expression of genes that... 相似文献
52.
Murat Ayaz Nizamettin Dalkilic Hulagu Bariskaner Seckin Tuncer Ilhami Demirel 《Biological trace element research》2007,116(3):301-309
Gender differences are related to the manner in which the heart responds to chronic and acute stress conditions of physiological
and pathological nature. Depending on dose, sodium selenite acts as an antioxidant proven to have beneficial effects in several
pathological conditions G. Drasch, J. Schopfer, and G. N. Schrauzer, Selenium/cadmium ratios in human prostates: indicators
of prostate cancer risk of smokers and non-smokers, and relevance to the cancer protective effects of selenium,Biol. Trace Element Res.
103(2), 103–107 (2005); R. G. Kasseroller and G. N. Schrauzer, Treatment of secondary lymphedema of the arm with physical decongestive
therapy and sodium selenite: a review,Am. J. Ther.
7(4), 273–279 (2000); G. N. Schrauzer, Anticarcinogenic effects of selenium,Cell. Mol. Life Sci.
57(13–14), 1864–1873 (2000); I. S. Palmer and O. E. Olson, Relative toxicities of selenite and selenate in the drinking water of rats,J. Nutr.
104(3), 306–314 (1974). To date, little is known about the gender-dependent direct effects of toxic doses of selenite on electrophysiology
of the cardiovascular system H. A. Schroeder and M. Mitchener, Selenium and tellurium in rats: effect on growth, survival
and tumors,J. Nutr.
101(11), 1531–1540 (1971); G. N. Schrauzer, The nutritional significance, metabolism and toxicology of selenomethionine,Adv. Food Nutr. Res.
47, 73–112 (2003). In the present study, the effects of in vitro toxic concentrations of sodium selenite ranging from 10-6 M to 10-3 M were tested on both male and female rat heart preparations. The toxic effects seen in an electrocardiogram and left ventricular
pressure were dose and sex dependent at most of the tested concentrations. The present study clearly shows that at toxic doses,
stress conditions are induced by selenite, resulting in gender-dependent modifications of the heart function. This modification
is more pronounced in the contraction cascade of female rats. Males, on the other hand, had been much more affected in excitation-related
parameters. 相似文献
53.
Sun Y Huang J Xiang Y Bastepe M Jüppner H Kobilka BK Zhang JJ Huang XY 《The EMBO journal》2007,26(1):53-64
G-protein-coupled receptors (GPCRs) mostly signal through heterotrimeric G proteins. Increasing evidence suggests that GPCRs could function in a G-protein-independent manner. Here, we show that at low concentrations of an agonist, beta(2)-adrenergic receptors (beta(2)-ARs) signal through Galpha(s) to activate the mitogen-activated protein kinase pathway in mouse embryonic fibroblast cells. At high agonist concentrations, signals are also transduced through beta(2)-ARs via an additional pathway that is G-protein-independent but tyrosine kinase Src-dependent. This new dosage-dependent switch of signaling modes of GPCRs has significant implications for GPCR intrinsic properties and desensitization. 相似文献
54.
Gul M Ciragil P Bulbuloglu E Aral M Alkis S Ezberci F 《Acta microbiologica et immunologica Hungarica》2007,54(3):317-321
Comamonas testosteroni is an uncommon isolate in the clinical laboratory as a human pathogen. C. testosteroni most commonly emerges in abdominal pathologies especially in perforated appendicitis. In Turkey we report first time a case of bacteremia due to this organism, in a 22-year-old man with perforated acute appendicitis. The organism was shown to be susceptible to routine antibiotics so it was easily eliminated even after having caused a bacteremia. 相似文献
55.
Rodrigo J Pena A Murat B Trueba M Durroux T Guillon G Rognan D 《Molecular endocrinology (Baltimore, Md.)》2007,21(2):512-523
Starting from the 2.8-A resolution x-ray structure of bovine rhodopsin, three-dimensional molecular models of the complexes between arginine vasopressin and two receptor subtypes (V1a, V1b) have been built. Amino acid sequence alignment and docking studies suggest that four key residues (1.35, 2.65, 4.61, and 5.35) fine tune the binding of vasopressin and related peptide agonists to both receptor subtypes. To validate these predictions, a series of single or double mutants were engineered at V1a and V1b receptor subtypes and tested for their binding and functional properties. Two negatively charged amino acids at positions 1.35 and 2.65 are key anchoring residues to the Arg8 residue of arginine vasopressin. Moreover, two amino acids (V(4.61) and P(5.35)) delineating a hydrophobic subsite at the human V1b receptor are responsible for the recognition of V1b selective peptide agonists. Last, one of the latter positions (5.35) is hypothesized to explain the pharmacological species differences between rat and human vasopressin receptors for a V1b peptide agonist. Altogether these refined three-dimensional models of V1a and V1b human receptors should enable the identification of further new selective V1a and V1b agonists as pharmacological but also therapeutic tools. 相似文献
56.
Our analysis highlights common statistical features of high-impact articles; we also show how information flows among various publication types. 相似文献
57.
Alexander L Chernorudskiy Alejandro Garcia Eugene V Eremin Anastasia S Shorina Ekaterina V Kondratieva Murat R Gainullin 《BMC bioinformatics》2007,8(1):126
Background
Post-translational protein modification with ubiquitin, or ubiquitylation, is one of the hottest topics in a modern biology due to a dramatic impact on diverse metabolic pathways and involvement in pathogenesis of severe human diseases. A great number of eukaryotic proteins was found to be ubiquitylated. However, data about particular ubiquitylated proteins are rather disembodied. 相似文献58.
59.
Sandra Muschiol Murat Balaban Staffan Normark Birgitta Henriques‐Normark 《BioEssays : news and reviews in molecular, cellular and developmental biology》2015,37(4):426-435
Transport of DNA across bacterial membranes involves complex DNA uptake systems. In Gram‐positive bacteria, the DNA uptake machinery shares fundamental similarities with type IV pili and type II secretion systems. Although dedicated pilus structures, such as type IV pili in Gram‐negative bacteria, are necessary for efficient DNA uptake, the role of similar structures in Gram‐positive bacteria is just beginning to emerge. Recently two essentially very different pilus structures composed of the same major pilin protein ComGC were proposed to be involved in transformation of the Gram‐positive bacterium Streptococcus pneumoniae – one is a long, thin, type IV pilus‐like fiber with DNA binding capacity and the other one is a pilus structure that was thicker, much shorter and not able to bind DNA. Here we discuss how competence induced pili, either by pilus retraction or by a transient pilus‐related opening in the cell wall, may mediate DNA uptake in S. pneumoniae. 相似文献
60.