Use of tablet forms of monomycin in children with acute dysentery]

The clinical picture of acute dysentery caused mainly by Shigella sonnei was studied in 160 children: 50 children were treated with monomycin tablets and for the treatment of 110 children monomycin in the form of amorphous powder in bottles was used. The treatment was carried out in accordance with the official instructions. Coincidence of the recovery time in the both groups was registered. When the patients were treated with monomycin tablets, 5 and 15-34 per cent of the antibiotic a daily dose was excreted with the urine and excrements respectively. It was concluded that monomycin in the from of tablets was more convenient in the treatment of children.     

Mechanisms of the adaptation of the Kildin cod <Emphasis Type="Italic">Gadus morhua kildinensis</Emphasis> Derjugin, 1920 (Pisces: Gadidae) to the specific conditions of Lake Mogilnoye

The mechanisms of the adaptation of the Kildin cod to the conditions of a meromictic lake were analyzed based on the study of morphological, biological, and genetic characteristics. Significant differences between the Kildin cod and Atlantic cod have been found in their morphological and genetic characteristics. The results of an X-ray microanalysis of otoliths, which were conducted for the first time, confirm that the distribution range of the Kildin cod in Lake Mogilnoye also extends to brackish waters. It has been shown that the formation of the reproductively isolated lacustrine population of Kildin cod is accompanied by specialization in a number of characteristics (body color, feeding strategy, behavior, etc.) and by a decrease in genetic diversity.     

Lipid peroxidation and myocardial contractile function in the post-ischemic period depending on the level of hypothermic protection of the heart]

The experiments on rats isolated hearts showed lipid peroxidation state to depend on myocardial cooling level in ischemic period. Cooling to 8-12 degrees C does not induce significant impairment in the system of lipid peroxidation/antioxidant activity, thus preventing the development of reperfusion impairment in cardiac activity restoration. Temperature decrease to 4-6 degrees C during the ischemic period results in lipid peroxidation, antioxidant cell system exhaustion and impairment of contractive myocardial function in reperfusion.     

The effect of different temperature regimens in reperfusion on the recovery of myocardial contractile function after hypothermic cardiac ischemia]

The changes of the contractile function of the heart and cAMP content in myocardium depending on the temperature conditions of reperfusion (28 degrees C, 32 degrees C, 37 degrees C) after 90 minutes of hypothermal ischemia have been investigated on isolated hearts of rats. The comparative analysis of the investigation results has shown that, after cooling a cardial muscle to 8-12 degrees C, reperfusion with initial temperature of perfusate of 32 degrees C promotes fast restoration of independent cardiac activity, does not cause formation of reperfusion contracture, normalizes processes of synthesis and cAMP utilization in cardiomyocytes.