排序方式: 共有135条查询结果,搜索用时 15 毫秒
101.
Muhammet Rasit Ugur Denise D. Guerreiro Arlindo A. Moura Erdogan Memili 《Animal Reproduction》2022,19(1)
Prediction of bull fertility is critical for the sustainability of both dairy and beef cattle production. Even though bulls produce ample amounts of sperm with normal parameters, some bulls may still suffer from subpar fertility. This causes major economic losses in the cattle industry because using artificial insemination, semen from one single bull can be used to inseminate hundreds of thousands of cows. Although there are several traditional methods to estimate bull fertility, such methods are not sufficient to explain and accurately predict the subfertility of individual bulls. Since fertility is a complex trait influenced by a number of factors including genetics, epigenetics, and environment, there is an urgent need for a comprehensive methodological approach to clarify uncertainty in male subfertility. The present review focuses on molecular and functional signatures of bull sperm associated with fertility. Potential roles of functional genomics (proteome, small noncoding RNAs, lipidome, metabolome) on determining male fertility and its potential as a fertility biomarker are discussed. This review provides a better understanding of the molecular signatures of viable and fertile sperm cells and their potential to be used as fertility biomarkers. This information will help uncover the underlying reasons for idiopathic subfertility. 相似文献
102.
Physiology and Molecular Biology of Plants - Salinity is one of the most severe abiotic stress factors that limit crop productivity by affecting the growth of plants. Therefore, it is significant... 相似文献
103.
Baltaci Saltuk Bugra Mogulkoc Rasim Baltaci Abdulkerim Kasim 《Neurochemical research》2019,44(2):281-296
Neurochemical Research - LTP is the most intensively studied cellular model of the memory and generally divided at least two distinct phases as early and late. E-LTP requires activation of CaMKII... 相似文献
104.
Dundar Ayca Bayramov Ruslan Onal Muge G. Akkus Mustafa Dogan Muhammet E. Kenanoglu Sercan Cerrah Gunes Meltem Kazimli Ulviye Ozbek Mehmet N. Ercan Oya Yildirim Ruken Celmeli Gamze Parlak Mesut Dundar Ismail Hatipoglu Nihal Unluhizarci Kursad Akalin Hilal Ozkul Yusuf Saatci Cetin Dundar Munis 《Molecular biology reports》2019,46(4):3677-3690
Molecular Biology Reports - Congenital adrenal hyperplasia (CAH) is an autosomal recessive genetic disorder due to presence of mutations in the genes involved in the metabolism of steroid hormones... 相似文献
105.
Demirel Sevgi Öz Hatice Öznur Güneş Muhammet Çiner Fehiman Adın Selahattin 《The International Journal of Life Cycle Assessment》2019,24(6):1139-1153
The International Journal of Life Cycle Assessment - In this study, fresh, mechanical, microstructural, and thermal properties as well as environmental impact of self-compacting mortars (SCMs) were... 相似文献
106.
Melania Balzarolo Sander Engels Anja J. de Jong Katka Franke Timo K. van den Berg Muhammet F. Gulen Andrea Ablasser Edith M. Janssen Bas van Steensel Monika C. Wolkers 《Open biology》2021,11(3)
Nucleic acid sensing through pattern recognition receptors is critical for immune recognition of microbial infections. Microbial DNA is frequently methylated at the N6 position of adenines (m6A), a modification that is rare in mammalian host DNA. We show here how that m6A methylation of 5′-GATC-3′ motifs augments the immunogenicity of synthetic double-stranded (ds)DNA in murine macrophages and dendritic cells. Transfection with m6A-methylated DNA increased the expression of the activation markers CD69 and CD86, and of Ifnβ, iNos and Cxcl10 mRNA. Similar to unmethylated cytosolic dsDNA, recognition of m6A DNA occurs independently of TLR and RIG-I signalling, but requires the two key mediators of cytosolic DNA sensing, STING and cGAS. Intriguingly, the response to m6A DNA is sequence-specific. m6A is immunostimulatory in some motifs, but immunosuppressive in others, a feature that is conserved between mouse and human macrophages. In conclusion, epigenetic alterations of DNA depend on the context of the sequence and are differentially perceived by innate cells, a feature that could potentially be used for the design of immune-modulating therapeutics. 相似文献
107.
Kaya EG Ozbilge H Ustundag MB Torun YA 《Acta microbiologica et immunologica Hungarica》2011,58(4):279-288
The aim of this study was to investigate the effects on the immune response of levamisole alone and in conjunction with Candida albicans stimulation in human macrophage cell culture by determining the alterations in the levels of cytokine release. Levamisole treatment was performed before, during and after infecting U-937 human macrophage cells with C. albicans. In cell supernatants, interleukin (IL)-1b, IL-12, IL-18, tumour necrosis factor alpha (TNF-α) levels were measured by ELISA. In vitro levamisole treatment accompanied by C. albicans stimulation significantly increased IL-12, IL-1β and IL-18 production in macrophage cells (p < 0.05). It was observed that when administered before C. albicans infection, levamisole significantly increased IL-12 and IL-1β production in macrophage cells (p < 0.05). Another finding was that when applied to macrophage cells simultaneously with C. albicans infection, or before infection with C. albicans, levamisole suppressed the TNF-β production stimulating effect of C. albicans (p < 0.05). These results indicated that levamisole could be useful in treating patients infected with C. albicans or in protecting individuals under the risk of being infected with this pathogen. There is a need for further experimental and clinical studies on this hypothesis. 相似文献
108.
Familial Mediterranean fever (FMF) is the most frequent hereditary inflammatory disease. FMF causes different clinical manifestations
in different ethnic groups and countries. In this study, we retrospectively reviewed the records of 1,152 FMF suspected patients
(673 female and 479 male) from November 2006 to December 2010. A commercial kit assay for the identification of MEFV (Mediterranean fever) gene mutations based on PCR and reverse-hybridization was used to investigate 12 mutations of the MEFV gene. 52.17% of 1,152 FMF suspected patients had MEFV mutation and 45.25% of them were male. The rate of MEFV mutation among male and female patients were 56.78 and 48.88%, respectively. These results were statistically significant
and might support the suggestion that FMF had much more penetrance in male patients (P = 0.009). Not any significant difference was observed between the male and female patients in terms of heterozygote and homozygote
mutation carriage rate (P = 0.071). Also not any significant difference was observed between the male and female patients in terms of compound heterozygote
mutation carriage rate (P = 0.058). 相似文献
109.
110.