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51.
Khalid K Alharbi Alaa Salem Abed Rabbani Syed Imran Ali khan Sabeena Muhammed Mustafa 《Bioinformation》2012,8(25):1260-1264
The evolutionary conservation of a housekeeping gene such as G6PD is greater than that of tissue-specific genes, presumably
because the latter may require more specific adaptation to the physiology of individual organisms. The abundance of distinct
mutation sites and their clinical manifestations make G6PD ideal for structure-function analysis. Therefore, it is of interest to screen
of G6PD deficiency in the blood donors in Kingdom of Saudi Arabia. We report the mean and variation of enzyme activity in a
huge set of Suadi to non-Saudi population with reference to the entire population. The sequence level conservation of G6PD among
distant species is demonstrated using phylogenetic trees. These observations have implications in the sequence-structure-function
understanding of G6PD with reference to its association to several human diseases. 相似文献
52.
Stanley Tam Haiyuan Yu Kavitha Venkatesan Danny Mou Venus Swearingen Muhammed A Yildirim Han Yan Amélie Dricot David Szeto Chenwei Lin Tong Hao Changyu Fan Stuart Milstein Denis Dupuy Robert Brasseur David E Hill Michael E Cusick Marc Vidal 《Molecular systems biology》2009,5(1)
Cellular functions are mediated through complex systems of macromolecules and metabolites linked through biochemical and physical interactions, represented in interactome models as ‘nodes’ and ‘edges’, respectively. Better understanding of genotype‐to‐phenotype relationships in human disease will require modeling of how disease‐causing mutations affect systems or interactome properties. Here we investigate how perturbations of interactome networks may differ between complete loss of gene products (‘node removal’) and interaction‐specific or edge‐specific (‘edgetic’) alterations. Global computational analyses of ~50 000 known causative mutations in human Mendelian disorders revealed clear separations of mutations probably corresponding to those of node removal versus edgetic perturbations. Experimental characterization of mutant alleles in various disorders identified diverse edgetic interaction profiles of mutant proteins, which correlated with distinct structural properties of disease proteins and disease mechanisms. Edgetic perturbations seem to confer distinct functional consequences from node removal because a large fraction of cases in which a single gene is linked to multiple disorders can be modeled by distinguishing edgetic network perturbations. Edgetic network perturbation models might improve both the understanding of dissemination of disease alleles in human populations and the development of molecular therapeutic strategies. 相似文献
53.
Background
Morbidity associated with primary headache disorders is a major public health problem with an overall prevalence of 46%. Tension-type headache and migraine are the two most prevalent causes. However, headache has not been sufficiently studied as a cause of morbidity in the developing world. Literature on prevalence and classification of these disorders in South Asia is scarce. The aim of this study is to describe the classification and clinical features of headache patients who seek medical advice in Pakistan.Methods and Results
Medical records of 255 consecutive patients who presented to a headache clinic at a tertiary care hospital were reviewed. Demographic details, onset and lifetime duration of illness, pattern of headache, associated features and family history were recorded. International Classification of Headache Disorders version 2 was applied.66% of all patients were women and 81% of them were between 16 and 49 years of age. Migraine was the most common disorder (206 patients) followed by tension-type headache (58 patients), medication-overuse headache (6 patients) and cluster headache (4 patients). Chronic daily headache was seen in 99 patients. Patients with tension-type headache suffered from more frequent episodes of headache than patients with migraine (p<0.001). Duration of each headache episode was higher in women with menstrually related migraine (p = 0.015). Median age at presentation and at onset was lower in patients with migraine who reported a first-degree family history of the disease (p = 0.003 and p<0.001 respectively).Conclusions/Significance
Patients who seek medical advice for headache in Pakistan are usually in their most productive ages. Migraine and tension-type headache are the most common clinical presentations of headache. Onset of migraine is earlier in patients with first-degree family history. Menstrually related migraine affects women with headache episodes of longer duration than other patients and it warrants special therapeutic consideration. Follow-up studies to describe epidemiology and burden of headache in Pakistan are needed. 相似文献54.
55.
Ludidi N Morse M Sayed M Wherrett T Shabala S Gehring C 《Plant & cell physiology》2004,45(8):1093-1098
Plant natriuretic peptides (PNPs) belong to a novel class of systemically mobile molecules that are structurally similar to the N-terminal domain of expansins and affect physiological processes such as protoplast volume regulation at nano-molar concentrations. Here we demonstrate that AtPNP-A, a recombinant Arabidopsis thaliana PNP causes rapid H(+) influx in the elongation zone of A. thaliana roots but not in the mature zone. AtPNP-A also induces significant K(+) and Na(+) efflux and this effect is seen in the mature root zone only. These observations suggest that responses to AtPNP-A are developmental stage and tissue specific and point to a complex role in plant growth and homeostasis. 相似文献
56.
Summary Immobilization of Saccharum officinarum cells within the vegetable sponge of Luffa cylindrica is reported as a new medium for the cells of higher plants. The use of biostructure of the sponge offers an alternative matrix to the ones used presently for immobilization. 相似文献
57.
In this study, the plant node was dried in an oven (40, 50 and 60 °C), shade and temperature-controlled microwave (40, 50 and 60 °C) methods. Statistically (p<0.05), the values closest to the color values of fresh grass were determined in an oven at 40 °C drying temperature. Effective diffusion values varied between 8.85×10−8–5.65×10−6 m2 s−1. While the activation energy was 61.28 kJ mol−1 in the oven, it was calculated as 85.24 kJ mol−1 in the temperature-controlled microwave. Drying data was best estimated in the Midilli-Küçük (R2 0.9998) model oven at 50 °C. The highest SMER value was calculated as 0.0098 kg kWh−1 in the temperature-controlled microwave drying method. The lowest SEC value in the temperature-controlled microwave was determined as 24.03 kWh kg−1. It was determined that enthalpy values varied between −2484.66/−2623.38 kJ mol−1, entropy values between −162.04/−122.65 J mol−1 and Gibbs free energy values between 453335.22–362581.40 kJ mol−1. Drying rate values were calculated in the range of 0.0127–0.9820 g moisture g dry matter−1 in the temperature-controlled microwave, 0.0003–0.0762 g dry matter−1 in the oven, and 0.001–0.0058 g moisture g dry moisture matter−1 in the shade. Phenolic content 6957.79 μg GAE g−1 fw - 48322.27 μg GAE g−1 dw, flavonoid content 3806.67 mg KE L−1 fw - 22200.00 mg KE L−1 dw and antioxidant capacity 43.35 μmol TE g−1 fw - 323.47 μmol TE g−1 dw. The highest chlorophyll values were obtained from samples dried in an oven at 40 °C. According to the findings, it is recommended to dry the knotweed (Polygonum cognatum Meissn.) plant in a temperature-controlled microwave oven at low temperatures. In this study, in terms of drying kinetics and energy parameters, a temperature-controlled microwave dryer of 60 °C is recommended, while in terms of quality characteristics, oven 40 °C and shade methods are recommended. 相似文献
58.
59.
Yunes Panahi Omid Fazlolahzadeh Stephen L. Atkin Muhammed Majeed Alexandra E. Butler Thomas P. Johnston Amirhossein Sahebkar 《Journal of cellular physiology》2019,234(2):1165-1178
Curcumin, a natural polyphenolic and yellow pigment obtained from the spice turmeric, has strong antioxidative, anti-inflammatory, and antibacterial properties. Due to these properties, curcumin has been used as a remedy for the prevention and treatment of skin aging and disorders such as psoriasis, infection, acne, skin inflammation, and skin cancer. Curcumin has protective effects against skin damage caused by chronic ultraviolet B radiation. One of the challenges in maximizing the therapeutic potential of curcumin is its low bioavailability, limited aqueous solubility, and chemical instability. In this regard, the present review is focused on recent studies concerning the use of curcumin for the treatment of skin diseases, as well as offering new and efficient strategies to optimize its pharmacokinetic profile and increase its bioavailability. 相似文献
60.
van den Broek I Amsalu R Balasegaram M Hepple P Alemu E Hussein el B Al-Faith M Montgomery J Checchi F 《Malaria journal》2005,4(1):14-7