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991.
Ali Shafaqat Rizwan Muhammad Zaid Abbu Arif Muhammad Saleem Yasmeen Tahira Hussain Afzal Shahid Muhammad Rizwan Bukhari Syed Asad Hussain Hussain Saddam Abbasi Ghulam Hassan 《Journal of Plant Growth Regulation》2018,37(4):1423-1436
Journal of Plant Growth Regulation - Plants face different types of biotic and abiotic stresses during their life span. Heavy metal (HM) stress is considered as one of the most challenging and... 相似文献
992.
Kiran Nawaz Ahmad Ali Shahid Louis Bengyella Muhammad Nasir Subhani Muhammad Ali Waheed Anwar Sehrish Iftikhar Shinawar Waseem Ali 《World journal of microbiology & biotechnology》2018,34(9):130
Chili pepper (Capsicum annum L.) is an important economic crop that is severely destroyed by the filamentous oomycete Phytophthora capsici. Little is known about this pathogen in key chili pepper farms in Punjab province, Pakistan. We investigated the genetic diversity of P. capsici strains using standard taxonomic and molecular tools, and characterized their colony growth patterns as well as their disease severity on chili pepper plants under the greenhouse conditions. Phylogenetic analysis based on ribosomal DNA (rDNA), β-tubulin and translation elongation factor 1α loci revealed divergent evolution in the population structure of P. capsici isolates. The mean oospore diameter of mating type A1 isolates was greater than that of mating type A2 isolates. We provide first evidence of an uneven distribution of highly virulent mating type A1 and A2 of P. capsici that are insensitive to mefenoxam, pyrimorph, dimethomorph, and azoxystrobin fungicides, and represent a risk factor that could ease outpacing the current P. capsici management strategies. 相似文献
993.
Sandeep Rana Yogesh A. Sonawane Margaret A. Taylor Smitha Kizhake Muhammad Zahid Amarnath Natarajan 《Bioorganic & medicinal chemistry letters》2018,28(23-24):3736-3740
We synthesized a library of aminopyrazole analogs to systematically explore the hydrophobic pocket adjacent to the hinge region and the solvent exposed region of cyclin dependent kinases. Structure-activity relationship studies identified an optimal substitution for the hydrophobic pocket and analog 24 as a potent and selective CDK2/5 inhibitor. 相似文献
994.
Huasong Peng Jian Tan Muhammad Bilal Wei Wang Hongbo Hu Xuehong Zhang 《World journal of microbiology & biotechnology》2018,34(9):129
Phenazine-1-carboxamide (PCN) is one of the major biocontrol agents produced by plant growth-promoting rhizosphere (PGPR) pseudomonads including Pseudomonas chlororaphis. In this study, a combined strategy of genetic modification and statistical experimental designs was applied to obtain mutants of P. chlororaphis strains with high-yield PCN production. To achieve this, the lon gene was knocked out in wild-type P. chlororaphis HT66 and the breeding mutant P3 strain with a non-scar deletion strategy. The resulting HT66Δlon and P3Δlon mutants produced a significantly higher PCN production in shake-flask cultures which was 5- and 9-folds greater than their native counterparts. The potential ability of strain P3Δlon for PCN production was further optimized by statistical designs. A two-level Plackett–Burman (PB) experimental design with six variables was employed to scrutinize medium components that significantly influence PCN production. Notably, glycerol, tryptone, and soy peptone were identified to be the most significant factors (p?<?0.05). Response surface methodology (RSM) based on the central composite design (CCD) was adopted to determine these factors optimal levels and their interactive effects between culture components for PCN production. The predicted maximum PCN production was 9002 mg/L, whereas an actual PCN production of 9174 mg/L was recorded in the validation experiments using the optimal medium containing glycerol 37.08 mL/L, tryptone 20.00 g/L, and soy peptone 25.03 g/L, which was nearly threefolds higher than without optimization and 20-folds higher than the wild-type strain. In conclusion, the results revealed that P. chlororaphis display a high potential for industrial-scale production for phenazine biopesticides. 相似文献
995.
Nuzhat Arshad Jamshed Hashim Muhammad Ali Minhas Javeria Aslam Tahira Ashraf Syeda Zehra Hamid Tahseen Iqbal Shumaila Javed 《Bioorganic & medicinal chemistry letters》2018,28(19):3251-3254
Four series of heterocyclic compounds, namely, tetrahydro-2H-1,3,5-thiadiazine thione derivatives were synthesized in good to excellent yields and were screened for their in vitro antileishmanial activities against Leishmania major (promastigotes). Most of the compounds showed significant antileishmanial activity within the range of IC50?=?15.48–39.36?μM when compared with standard pentamidine (IC50?=?14.95?μM). The structure-activity relationship showed that N-3 and N-5 substituents have a key role against leishmanicidal activity. The ester analogues (series B) were found to have a 1.5 to 5-fold reduced activity compared to their acidic counterparts. Cytotoxicity against mammalian mouse fibroblast 3?T3 cells was also evaluated and compared between the acid and its ester analogue. The reduction of antileishmanial activity and loss of toxicity in the newly developed THTT ester derivative indicates that these compounds can be used as a template study for the production of effective antileishmanial ester prodrugs. 相似文献
996.
Proteomic analysis of positive influence of alternate wetting and moderate soil drying on the process of rice grain filling 总被引:1,自引:0,他引:1
Zhong Li Zhou Li Waqas Muhammad Manhong Lin Saadia Azeem Hong Zhao Sheng Lin Ting Chen Changxun Fang Puleng Letuma Zhixing Zhang Wenxiong Lin 《Plant Growth Regulation》2018,84(3):533-548
Rice (Oryza sativa L.) is one of the most important crops in the world to feed ever increasing world population. An increase in output of rice crop per unit is imminent. Alternate wetting and moderate soil drying (AWD) irrigation technology has been recommended as a good practice method to improve grain filling of rice crop at late growing stages. Physiological, molecular and agronomic parameters were adopted to elucidate the role of rice stem and sheath under AWD treatment as compared to the conventional irrigation during the grain filling stage. AWD treatment significantly increased stem and sheath dry weight, carbohydrate reserves and their remobilization to the grain, especially inferior spikelet grains. The results showed that the transport and conversion rate of the stem and sheath photoassimilates increased by 9.87 and 8.37%, respectively. Furthermore, protein expression profiles of the stem and sheath at 10, 20 and 30 days after flowering were analyzed. We examined 220 differentially expressed proteins, and successfully identified 166 proteins, including 71 proteins in the stem and 95 proteins in the sheath involved in thirteen important functional groups. Our results suggest that the AWD treatment at the rice grain filling stage is highly conducive to trigger the mobilization of the N assimilates from leave and root to the stem and sheath, and then promotes to remobilize the reserves to the grain through coordinately expressed proteins involved in photosynthesis, systematic senescence, oxidative stress defense, signal transduction and other metabolisms. This study reveals the metabolic mechanism of the stem and sheath in response to AWD at grain filling stage, and provides theoretical evidence for better quality control and scientific improvement of rice in practice. 相似文献
997.
998.
Ovais Muhammad Khalil Ali Talha Islam Nazar Ul Ahmad Irshad Ayaz Muhamamd Saravanan Muthupandian Shinwari Zabta Khan Mukherjee Sudip 《Applied microbiology and biotechnology》2018,102(16):6799-6814
Applied Microbiology and Biotechnology - Metal-based nanoparticles have gained tremendous popularity because of their interesting physical, biological, optical, and magnetic properties. These... 相似文献
999.
Ovais Muhammad Khalil Ali Talha Raza Abida Islam Nazar Ul Ayaz Muhammad Saravanan Muthupandian Ali Muhammad Ahmad Irshad Shahid Muhammad Shinwari Zabta Khan 《Applied microbiology and biotechnology》2018,102(10):4393-4408
Applied Microbiology and Biotechnology - Phytochemicals offer immense promise for sustainable development and production of nanotechnology-enabled products. In the present study, Olax nana Wall. ex... 相似文献
1000.