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201.
Wan-Jun Chen Sheng-Jie Lai Yang Yang Kun Liu Xin-Lou Li Hong-Wu Yao Yu Li Hang Zhou Li-Ping Wang Di Mu Wen-Wu Yin Li-Qun Fang Hong-Jie Yu Wu-Chun Cao 《PLoS neglected tropical diseases》2016,10(4)
BackgroundAnthrax, a global re-emerging zoonotic disease in recent years is enzootic in mainland China. Despite its significance to the public health, spatiotemporal distributions of the disease in human and livestock and its potential driving factors remain poorly understood.Conclusions/SignificanceAnthrax in China was characterized by significant seasonality and spatial clustering. The spatial distribution of human anthrax was largely driven by livestock husbandry, human density, land cover, elevation, topsoil features and climate. Enhanced surveillance and intervention for livestock and human anthrax in the high-risk regions, particularly on the Qinghai-Tibetan Plateau, is the key to the prevention of human infections. 相似文献
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Eva del Amo Cristina Esteva Susanna Hernandez-Bou Carmen Galles Marian Navarro Goretti Sauca Alvaro Diaz Paula Gassiot Carmina Marti Nieves Larrosa Pilar Ciruela Mireia Jane Raquel Sá-Le?o Carmen Mu?oz-Almagro Catalan Study Group of Invasive Pneumococcal Disease 《PloS one》2016,11(3)
The aim of this study was to study the serotypes and clonal diversity of pneumococci causing invasive pneumococcal disease in Catalonia, Spain, in the era of 13-valent pneumococcal conjugate vaccine (PCV13). In our region, this vaccine is only available in the private market and it is estimated a PCV13 vaccine coverage around 55% in children. A total of 1551 pneumococcal invasive isolates received between 2010 and 2013 in the Molecular Microbiology Department at Hospital Sant Joan de Déu, Barcelona, were included. Fifty-two serotypes and 249 clonal types—defined by MLST—were identified. The most common serotypes were serotype 1 (n = 182; 11.7%), 3 (n = 145; 9.3%), 19A (n = 137; 8.8%) and 7F (n = 122; 7.9%). Serotype 14 was the third most frequent serotype in children < 2 years (15 of 159 isolates). PCV7 serotypes maintained their proportion along the period of study, 16.6% in 2010 to 13.4% in 2013, whereas there was a significant proportional decrease in PCV13 serotypes, 65.3% in 2010 to 48.9% in 2013 (p<0.01). This decrease was mainly attributable to serotypes 19A and 7F. Serotype 12F achieved the third position in 2013 (n = 22, 6.4%). The most frequent clonal types found were ST306 (n = 154, 9.9%), ST191 (n = 111, 7.2%), ST989 (n = 85, 5.5%) and ST180 (n = 80, 5.2%). Despite their decrease, PCV13 serotypes continue to be a major cause of disease in Spain. These results emphasize the need for complete PCV13 vaccination. 相似文献
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Meghan R. Mason Carolina Encina Srinand Sreevatsan Claudia Mu?oz-Zanzi 《PLoS neglected tropical diseases》2016,10(8)
BackgroundLeptospirosis is a neglected zoonosis affecting animals and humans caused by infection with Leptospira. The bacteria can survive outside of hosts for long periods of time in soil and water. While identification of Leptospira species from human cases and animal reservoirs are increasingly reported, little is known about the diversity of pathogenic Leptospira species in the environment and how surveillance of the environment might be used for monitoring and controlling disease.ConclusionsThis study reports the presence of pathogenic Leptospira in the peri-domestic environment of households in three community types and the differences in Leptospira diversity at the community level. Systematic environmental surveillance of Leptospira can be used for detecting changes in pathogen diversity and to identify and monitor contaminated areas where an increased risk of human infection exists. 相似文献
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ángela María Sánchez-López Abdellatif Bahaji Nuria De Diego Marouane Baslam Jun Li Francisco José Mu?oz Goizeder Almagro Pablo García-Gómez Kinia Ameztoy Adriana Ricarte-Bermejo Ond?ej Novák Jan F. Humplík Luká? Spíchal Karel Dole?al Sergio Ciordia María Carmen Mena Rosana Navajas Edurne Baroja-Fernández Javier Pozueta-Romero 《Plant physiology》2016,172(3):1989-2001
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Approximate parameter inference in systems biology using gradient matching: a comparative evaluation
Benn Macdonald Mu Niu Simon Rogers Maurizio Filippone Dirk Husmeier 《Biomedical engineering online》2016,15(1):80