全文获取类型
收费全文 | 432篇 |
免费 | 77篇 |
国内免费 | 1篇 |
专业分类
510篇 |
出版年
2022年 | 3篇 |
2021年 | 4篇 |
2019年 | 4篇 |
2017年 | 7篇 |
2016年 | 7篇 |
2015年 | 12篇 |
2014年 | 21篇 |
2013年 | 12篇 |
2012年 | 20篇 |
2011年 | 22篇 |
2010年 | 8篇 |
2009年 | 11篇 |
2008年 | 19篇 |
2007年 | 15篇 |
2006年 | 11篇 |
2005年 | 19篇 |
2004年 | 15篇 |
2003年 | 15篇 |
2002年 | 17篇 |
2001年 | 16篇 |
2000年 | 18篇 |
1999年 | 13篇 |
1998年 | 10篇 |
1997年 | 6篇 |
1996年 | 6篇 |
1995年 | 8篇 |
1994年 | 4篇 |
1992年 | 13篇 |
1991年 | 14篇 |
1990年 | 8篇 |
1989年 | 12篇 |
1988年 | 8篇 |
1987年 | 10篇 |
1986年 | 6篇 |
1985年 | 10篇 |
1984年 | 6篇 |
1983年 | 6篇 |
1982年 | 4篇 |
1981年 | 3篇 |
1980年 | 4篇 |
1979年 | 8篇 |
1978年 | 3篇 |
1977年 | 4篇 |
1976年 | 3篇 |
1975年 | 7篇 |
1974年 | 4篇 |
1966年 | 7篇 |
1944年 | 3篇 |
1936年 | 4篇 |
1935年 | 4篇 |
排序方式: 共有510条查询结果,搜索用时 9 毫秒
61.
Jack T. Moyer 《Journal of Ethology》1984,2(2):85-98
Social organization and reproductive behavior were studied in 4 species of ostraciid fishes.Lactoria fornasini andLactoria diaphana from Japan andAcanthostracion polygonius from the western Atlsnyiv were usually found in single male, haremic social groups, although the latter 2 species usually
included only 2 females per harem, and individuals in all 3 species foraged solitarily. Elements of both “resource defense”
and “female defense” (Emlen & Oring 1977) were evident in the 2Lactoria species, and female defense appeared particularly intense inL. diaphana. Resource defense was apparent inA. polygonius. Lactophrys triquetor occurred in lek-like breeding assemblages at Curacao (Netherlands Antilles) and on the Atlantic coast of Panama. These variations
in social organization are discussed and a relationship with feeding habits is suggested. All 4 species appear to be gonochores
(demonstrated inLactoria by Moyer 1979). The 2Lactoria spp. showed operational sex ratios (OSR: Emlen & Oring 1977) approaching 1∶1 and a high degree of female spawning synchrony.
The occurrence of polygyny in species with 1∶1 OSRs and female spawning synchrony is discussed with reference to the Knowlton
(1979) model which predicts monogamy to occur in such situations. 相似文献
62.
Regulation of Bacteriophage T5 Development by ColI Factors 总被引:4,自引:10,他引:4
The I-type colicinogenic factor ColIb transforms Escherichia coli from a permissive to a nonpermissive host for bacteriophage T5 reproduction by preventing complete expression of the phage genome. T5-infected ColIb(+) cells synthesize only class I (early) phage protein and ribonucleic acid (RNA). Neither phage-specific class II proteins [associated with viral deoxyribonucleic acid (DNA) replication] nor class III proteins (phage structural components) are formed due to the failure of the infected ColIb(+) cells to synthesize class II or class III phage-specific messenger RNA. Comparable studies with T5-infected cells colicinogenic for the related ColIa factor revealed no decrease in the yield of progeny phage although the presence of the ColIa factor leads to a significant reduction in the amount of phage-directed class III protein synthesis. 相似文献
63.
Paul Welaga Cheryl A. Moyer Raymond Aborigo Philip Adongo John Williams Abraham Hodgson Abraham Oduro Cyril Engmann 《PloS one》2013,8(3)
Objectives
To determine the neonatal mortality rate in the Kassena-Nankana District (KND) of northern Ghana, and to identify the leading causes and timing of neonatal deaths.Methods
The KND falls within the Navrongo Health Research Centre’s Health and Demographic Surveillance System (HDSS), which uses trained field workers to gather and update health and demographic information from community members every four months. We utilized HDSS data from 2003–2009 to examine patterns of neonatal mortality.Results
A total of 17,751 live births between January 2003 and December 2009 were recorded, including 424 neonatal deaths 64.8%(275) of neonatal deaths occurred in the first week of life. The overall neonatal mortality rate was 24 per 1000 live births (95%CI 22 to 26) and early neonatal mortality rate was 16 per 1000 live births (95% CI 14 to 17). Neonatal mortality rates decreased over the period from 26 per 1000 live births in 2003 to 19 per 1000 live births in 2009. In all, 32%(137) of the neonatal deaths were from infections, 21%(88) from birth injury and asphyxia and 18%(76) from prematurity, making these three the leading causes of neonatal deaths in the area. Birth injury and asphyxia (31%) and prematurity (26%) were the leading causes of early neonatal deaths, while infection accounted for 59% of late neonatal deaths. Nearly 46% of all neonatal deaths occurred during the first three postnatal days. In multivariate analysis, multiple births, gestational age <32 weeks and first pregnancies conferred the highest odds of neonatal deaths.Conclusions
Neonatal mortality rates are declining in rural northern Ghana, with majority of deaths occurring within the first week of life. This has major policy, programmatic and research implications. Further research is needed to better understand the social, cultural, and logistical factors that drive high mortality in the early days following delivery. 相似文献64.
Plasmid expression and maintenance during long-term starvation-survival of bacteria in well water. 总被引:2,自引:7,他引:2 下载免费PDF全文
Strains of enteric bacteria and pseudomonads containing plasmid R388::Tnl721 (Tpr, Tcr) or pRO101 (Hgr, Tcr) were starved for over 250 days in sterile well water to evaluate effects of starvation-survival on plasmid expression and maintenance. Viable populations dropped to between approximately 0.1 and 1% of the initial populations. Escherichia coli(pRO101) and Pseudomonas cepacia(pRO101) lost both viability and plasmid expression at a lower rate than strains containing R388::Tnl721. Three patterns of host-plasmid interaction were detected: (i) no apparent loss of plasmid expression, (ii) loss of plasmid expression on initial recovery with subsequent expression upon resuscitation, and (iii) loss of capability to produce functional plasmid resistance. 相似文献
65.
66.
Zhao D Zhan Y Koon HW Zeng H Keates S Moyer MP Pothoulakis C 《The Journal of biological chemistry》2004,279(42):43547-43554
Expression of the neuropeptide neurotensin (NT) and its high affinity receptor (NTR1) is increased during the course of Clostridium difficile toxin A-induced acute colitis, and NTR1 antagonism attenuates the severity of toxin A-induced inflammation. We recently demonstrated in non-transformed human colonic epithelial NCM460 cells that NT treatment caused activation of a Ras-mediated MAP kinase pathway that significantly contributes to NT-induced interleukin-8 (IL-8) secretion. Here we used NCM460 cells, which normally express low levels of NTR1, and NCM460 cells stably transfected with NTR1 to identify the upstream signaling molecules involved in NT-NTR1-mediated MAP kinase activation. We found that inhibition of the epidermal growth factor receptor (EGFR) by either an EGFR neutralizing antibody or by its specific inhibitor AG1478 (0.2 microm) blocked NT-induced MAP kinase activation. Moreover, NT stimulated tyrosine phosphorylation of the EGFR, and pretreatment with a broad spectrum metalloproteinase inhibitor batimastat reduced NT-induced MAP kinase activation. Using neutralizing antibodies against the EGFR ligands EGF, heparin-binding-EGF, transforming growth factor-alpha (TGFalpha), or amphiregulin we have shown that only the anti-TGFalpha antibody significantly decreases NT-induced phosphorylation of EGFR and MAP kinases. Furthermore, inhibition of the EGF receptor by AG1478 significantly reduced NT-induced IL-8 promoter activity and IL-8 secretion. This is the first report demonstrating that NT binding to NTR1 transactivates the EGFR and that this response is linked to NT-mediated proinflammatory signaling. Our findings indicate that matrix metalloproteinase-mediated release of TGFalpha and subsequent EGFR transactivation triggers a NT-mediated MAP kinase pathway that leads to IL-8 gene expression in human colonic epithelial cells. 相似文献
67.
The molecular basis for Duchenne versus Becker muscular dystrophy: Correlation of severity with type of deletion 总被引:59,自引:23,他引:59 下载免费PDF全文
M. Koenig A. H. Beggs M. Moyer S. Scherpf K. Heindrich T. Bettecken G. Meng C. R. Müller M. Lindl?f H. Kaariainen A. de la Chapelle A. Kiuru M.-L. Savontaus H. Gilgenkrantz D. Récan J. Chelly J.-C. Kaplan A. E. Covone N. Archidiacono G. Romeo S. Liechti-Gallati V. Schneider S. Braga H. Moser B. T. Darras P. Murphy U. Francke J. D. Chen G. Morgan M. Denton C. R. Greenberg K. Wrogemann L. A. J. Blonden H. M. B. van Paassen G. J. B. van Ommen L. M. Kunkel 《American journal of human genetics》1989,45(4):498-506
About 60% of both Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) is due to deletions of the dystrophin gene. For cases with a deletion mutation, the "reading frame" hypothesis predicts that BMD patients produce a semifunctional, internally deleted dystrophin protein, whereas DMD patients produce a severely truncated protein that would be unstable. To test the validity of this theory, we analyzed 258 independent deletions at the DMD/BMD locus. The correlation between phenotype and type of deletion mutation is in agreement with the "reading frame" theory in 92% of cases and is of diagnostic and prognostic significance. The distribution and frequency of deletions spanning the entire locus suggests that many "in-frame" deletions of the dystrophin gene are not detected because the individuals bearing them are either asymptomatic or exhibit non-DMD/non-BMD clinical features. 相似文献
68.
69.
70.