全文获取类型
收费全文 | 377篇 |
免费 | 25篇 |
国内免费 | 1篇 |
出版年
2024年 | 1篇 |
2023年 | 1篇 |
2022年 | 16篇 |
2021年 | 19篇 |
2020年 | 21篇 |
2019年 | 33篇 |
2018年 | 17篇 |
2017年 | 19篇 |
2016年 | 26篇 |
2015年 | 23篇 |
2014年 | 26篇 |
2013年 | 35篇 |
2012年 | 27篇 |
2011年 | 21篇 |
2010年 | 19篇 |
2009年 | 20篇 |
2008年 | 11篇 |
2007年 | 14篇 |
2006年 | 8篇 |
2005年 | 7篇 |
2004年 | 6篇 |
2003年 | 2篇 |
2002年 | 7篇 |
2001年 | 5篇 |
2000年 | 2篇 |
1999年 | 2篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1994年 | 1篇 |
1992年 | 3篇 |
1991年 | 5篇 |
1990年 | 2篇 |
1982年 | 1篇 |
排序方式: 共有403条查询结果,搜索用时 15 毫秒
81.
Diabetic neuropathy is one of the most frequent complications of diabetes. Despite some studies, the exact mechanism of glucose
neurotoxicity has not been fully elucidated. Increased reactive oxygen species (ROS) has proposed as a possible mechanism.
Crocus sativus L. (saffron) has been known as a source of antioxidants. Therefore, neuroprotective effect of saffron extract, its active
component crocin and γ-glutamylcysteinylglycine (GSH) was studied in glucose-induced neurotoxicity, using PC12 cells as a
suitable in vitro model of diabetic neuropathy. Cell viability was quantitated by MTT assay. ROS was measured using DCF-DA
by flow cytometry analysis. The result showed that glucose (13.5 and 27 mg/ml) reduced the cell viability of PC12 cells after
4 days. Saffron extract (5 and 25 mg/ml), crocin (10 and 50 μM) and GSH (10 μM) could decrease this toxicity. Glucose toxicity
was consistent with increased ROS production which reduced by saffron, crocin and GSH pretreatment. These results suggest
saffron and its carotenoid crocin could be potentially useful in diabetic neuropathy treatment. 相似文献
82.
Shahrooz Vahedi Mehrnoosh Rajabian Arman Misaghian Daniel Grbec Horst H Simon Kambiz N Alavian 《Journal of biomedical science》2010,17(1):66
Background
Parkinson's disease is the second most common neurodegenerative disorder. The pathological hallmark of the disease is degeneration of midbrain dopaminergic neurons. Genetic association studies have linked 13 human chromosomal loci to Parkinson's disease. Identification of gene(s), as part of the etiology of Parkinson's disease, within the large number of genes residing in these loci can be achieved through several approaches, including screening methods, and considering appropriate criteria. Since several of the indentified Parkinson's disease genes are expressed in substantia nigra pars compact of the midbrain, expression within the neurons of this area could be a suitable criterion to limit the number of candidates and identify PD genes. 相似文献83.
84.
85.
86.
Razia Sultana Bina Shaheen Siddiqui Kambiz Taraz Herbert Budzikiewicz Jean-Marie Meyer 《Biometals》2000,13(2):147-152
From Pseudomonas putida CFML 90-51 – a hospital isolate – a pyoverdine was obtained which is characterized by the unusual linkage by the -rather than the -amino group of Lys in the peptide chain. The structure elucidation by spectroscopic methods and degradation reactions is reported. 相似文献
87.
88.
Budzikiewicz H Georgias H Taraz K 《Zeitschrift für Naturforschung. C, Journal of biosciences》2002,57(9-10):954-956
Coordination isomeric diastereomeric Cr3+ complexes of the pyoverdin of Pseudomonas aeruginosa ATCC 15692 could be separated by chromatography and characterized by spectroscopic methods. 相似文献
89.
Shang Ma Adrienne E. Dubin Yunxiao Zhang Seyed Ali Reza Mousavi Yu Wang Adam M. Coombs Meaghan Loud Immacolata Andolfo Ardem Patapoutian 《Cell》2021,184(4):969-982.e13
- Download : Download high-res image (152KB)
- Download : Download full-size image
90.
Bijan Ansari-Moghaddam Ali Asghar Kiani Ali Sheikhian Mehdi Birjandi Seyyed Amir Yasin Ahmadi Nazanin Mousavi Hamzeh Ali Torang Farhad Shahsavar 《Reports of Biochemistry & Molecular Biology》2021,10(1):84
Background:The pathophysiology underlying the progression and development of autoimmune conditions, such as Rheumatoid Arthritis (RA), is a result of dysregulations of the immune system. Research has explored the genetic alterations present in RA; however, limited studies have examined the role of Killer cell Immunoglobulin-like Receptors (KIR) and Human Leukocyte Antigen (HLA) molecules in RA. Therefore, the aim of this study was to examine KIR genes, their HLA ligands, and KIR-HLA compounds in patients with RA.Methods:In this case-control study, a total of 50 patients with RA and 100 healthy individuals were enrolled. DNA samples were evaluated using PCR with sequence specific Primers (PCR-SSP). Odds ratio (OR) with a 95% confidence interval (CI) were reported.Results:Among the KIR genes examined, KIR2DLA (p= 0.0255, OR= 0.389, 95% CI= 0.210-0.722) and KIR2DS4-full (p< 0.0001, OR= 6.163, 95% CI= 3.174-11.968) were observed to have a statistically significant correlation with disease susceptibility to RA. As an inhibitory gene, KIR2DLA was observed to have a protective effect against RA while KIR2DS4-full as an activating gene, was found to increase risk for RA. No significant associations were found between any of the other KIR genotypes, HLA ligands, or KIR-HLA compounds examined in this study to RA susceptibility. Conclusion:In this study of RA in the Lur population of Iran, KIR2DS4-full was observed to increase susceptibility to RA, while KIR2DL5A was found to act as a protecting factor based on both the cross Table and regression analyses. Further research should focus on repeating this study in additional populations.Key Words: HLA, KIR, NK cells, Rheumatoid Arthritis 相似文献