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361.
Kazuo Sugio Kazuo Ohuchi Motoko Sugata Susumu Tsurufuji 《Prostaglandins & other lipid mediators》1981,21(4):649-653
The present experiment was designed to investigate whether glucocorticoids counteract proinflammatory action of leukotrienes C and D which were suggested to play an important role as mediators in the inflammatory exudate response. Vascular permeability was measured using 131 I-labeled human serum albumin (131 I-HSA) as a tracer. The vascular permeability was elevated promptly after intradermal injection of chemically synthesized leukotriene C or D and then rapidly fell down to the control level. A positive dose-response relationship was observed in the dose levels of 0.01 – 1 μg of leukotrienes. Dexamethasone at doses of 0.15, 0.5 and 1.5 mg/kg caused dose-dependent suppression of vascular permeability response induced with leukotrienes C and D. The present data indicate that glucocorticoids are capable of exerting direct inhibitory effect against proinflammatory action of leukotriene C and D produced through phospholipase A2-arachidonate-lipoxygenase pathway. 相似文献
362.
The effect of various agar preparations in a chemically defined medium on promoting the development of taxonomic characteristics of streptomycetes was studied. Various agar products gave different results. Agar purified to a certain extent was favorable for good, constant development of such characteristics. The presence of certain metals played a great role in this domain. Agar purified to a high degree may give poor results unless supplemented with the proper metals. Recommendations were made for the standardization of agar media used for the study of characteristics of streptomycetes. 相似文献
363.
Kenichiro Inoue Takao Tanahashi Hiroyuki Inouye Fujio Murai Motoko Tagawa 《Phytochemistry》1982,21(2):359-361
The structure of jasminoside, a new secoiridoid glucoside isolated from Jasminum humile var. revolutum. was elucidated to be 10-cinnamoyloxyoleoside 7-methyl ester. 相似文献
364.
Takuya Morikawa Hiroaki Ohishi Kengo Kosaka Tomofumi Shimojo Akihiro Nagano Itsuki Taniguchi Ryuta Fujioka Kosei Moriyama Motoko Unoki Masatomo Takahashi Motonao Nakao Yoshihiro Izumi Takeshi Bamba Hiroyuki Sasaki Shiroh Miura Hiroki Shibata 《Bioscience reports》2021,41(2)
We have previously reported a novel homozygous 4-bp deletion in DDHD1 as the responsible variant for spastic paraplegia type 28 (SPG28; OMIM#609340). The variant causes a frameshift, resulting in a functionally null allele in the patient. DDHD1 encodes phospholipase A1 (PLA1) catalyzing phosphatidylinositol to lysophosphatidylinositol (LPI). To clarify the pathogenic mechanism of SPG28, we established Ddhd1 knockout mice (Ddhd1[−/−]) carrying a 5-bp deletion in Ddhd1, resulting in a premature termination of translation at a position similar to that of the patient. We observed a significant decrease in foot–base angle (FBA) in aged Ddhd1(−/−) (24 months of age) and a significant decrease in LPI 20:4 (sn-2) in Ddhd1(−/−) cerebra (26 months of age). These changes in FBA were not observed in 14 months of age. We also observed significant changes of expression levels of 22 genes in the Ddhd1(−/−) cerebra (26 months of age). Gene Ontology (GO) terms relating to the nervous system and cell–cell communications were significantly enriched. We conclude that the reduced signaling of LPI 20:4 (sn-2) by PLA1 dysfunction is responsible for the locomotive abnormality in SPG28, further suggesting that the reduction of downstream signaling such as GPR55 which is agonized by LPI is involved in the pathogenesis of SPG28. 相似文献
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367.
Kenji Mizuno Motoko Ojima Shigeatsu Hashimoto Soitsu Fukuchi 《Journal of neurochemistry》1985,45(2):626-629
High activity of renin was demonstrated in human neuroblastoma tissue. This activity was inhibited by specific antibody raised against human renal renin, indicating that it was not due to the nonspecific action of proteases. The specific activity of renin was 122.8 ng of angiotensin I generated mg of protein-1 h-1. It shared some biochemical features with well-known kidney renin, such as molecular weight, optimum pH, the presence of trypsin-activatable inactive renin, and glycoprotein nature. Furthermore, angiotensin-converting enzyme (ACE) activity (2.64 nmol mg of protein-1 min-1) was found in the tissue. This activity was inhibited by captopril, a specific ACE inhibitor, or by omission of chloride ion. These results suggest that true renin in addition to ACE exists in human neuroblastoma tissue. 相似文献