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991.
Mostafa M. Ghorab Maged S. Abdel-Kader Ali S. Alqahtani Aiten M. Soliman 《Journal of enzyme inhibition and medicinal chemistry》2021,36(1):218
A set of quinazolinones synthesized by the aid of L-norephedrine was assembled to generate novel analogues as potential anticancer and radiosensitizing agents. The new compounds were evaluated for their cytotoxic activity against MDA-MB-231, MCF-7, HepG-2, HCT-116 cancer cell lines and EGFR inhibitory activity. The most active compounds 5 and 6 were screened against MCF-10A normal cell line and displayed lower toxic effects. They proved their relative safety with high selectivity towards MDA-MB-231 breast cancer cell line. Measurement of the radiosensitizing activity for 5 and 6 revealed that they could sensitize the tumour cells after being exposed to a single dose of 8 Gy gamma radiation. Compound 5 was able to induce apoptosis and arrest the cell cycle at the G2-M phase. Molecular docking of 5 and 6 in the active site of EGFR was performed to gain insight into the binding interactions with the key amino acids. 相似文献
992.
993.
Majid Amiri Mostafa Fazli Amir Mokhtarieh Gholamhossein Grivani Ali Akbar Saboury 《Journal of biomolecular structure & dynamics》2013,31(14):3753-3772
This study was designed to investigate the interaction of three oxovanadium (IV) Schiff base complexes with bovine serum albumin (BSA) by means of various spectroscopic and electrochemical methods along with molecular docking study and molecular dynamics simulations. Binding constants were estimated by fluorescence and UV-Vis spectroscopy. The results indicated a good affinity of the complexes for BSA in which furyl derivative had more activity. Molecular docking study showed that these complexes have the similar binding modes and located within subdomain IB in site III of BSA. The supporting of molecular docking and molecular dynamics results by experimental data, confirms the validity of the interactions data obtained by these methods. Biological activity against cancer cell showed that furyl derivative has higher activity than other complexes. Pharmaceutical analysis also showed that, these complexes potentially can be used as anticancer agents. 相似文献
994.
Isolation and identification of chemotherapy‐enriched sphere‐forming cells from a patient with gastric cancer 下载免费PDF全文
995.
A total of 120 different samples belonging to 24 kinds of spices collected from different places atAssiut Governorate (Egypt) were examined for the natural occurrence of mycotoxins. TLC analysis of spice extracts revealed the presence of aflatoxins
(8–35 μg/kg) in 16 samples of anise, black pepper, caraway, black cumin, fennel, peppermint, coriander and marjoram, sterigmatocystin
(10–23 μg/kg) in ten samples of red pepper, caraway, cumin and marjoram and citrinin (8–12 ⧎g/kg) in two samples of black
cumin, while ochratoxin A and zearalenone could not be detected. 相似文献
996.
One hundred and two isolates of 30 species and 4 varieties belonging to 4 genera of xerophilous fungi were cultivated on cheese
whey. In fourteen species and one variety, all isolates (45) failed to grow on the cheese whey. The other species and varieties
(16 and 3) of fungi were able to grow and to accumulate variable amounts of lipid and sterol on whey.Aspergillus aureolatus, Eurotium repens, E. rubrum andEmericella nidulans var.lata produced high levels of lipids, total sterols and ergosterol whileE. tonophilum proved to be superior in the production of lipid (38±8%) of dry mycelial mass), total sterol (20±4%) and ergosterol (13±3%). 相似文献