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Effect of 2,4-dinitrophenol on the hypometabolic response to hypoxia of conscious adult rats 总被引:1,自引:0,他引:1
Saiki, Chikako, and Jacopo P. Mortola. Effect of2,4-dinitrophenol on the hypometabolic response to hypoxia of conscious adult rats. J. Appl. Physiol. 83(2):537-542, 1997.During acute hypoxia, a hypometabolic response iscommonly observed in many newborn and adult mammalian species. Wehypothesized that, if hypoxic hypometabolism were entirely a regulatedresponse with no limitation in O2availability, pharmacological uncoupling of the oxidativephosphorylation should raise O2consumption(O2) bysimilar amounts in hypoxia and normoxia. Metabolic, ventilatory, andcardiovascular measurements were collected from conscious rats in airand in hypoxia, both before and after intravenous injection of themitochondrial uncoupler 2,4-dinitrophenol (DNP). In hypoxia (10%O2 breathing, 60% arterialO2 saturation),O2, as measured by anopen-flow technique, was less than in normoxia (~80%). SuccessiveDNP injections (6 mg/kg, 4 times) progressively increasedO2 in both normoxia andhypoxia by similar amounts. Body temperature slightly increased innormoxia, whereas it did not change in hypoxia. The DNP-stimulatedO2 during hypoxia couldeven exceed the control normoxic value. A single DNP injection (17 mg/kg iv) had a similar metabolic effect; it also resulted inhypotension and a drop in systemic vascular resistance. We concludethat pharmacological stimulation ofO2 counteracts theO2 drop determined byhypoxia and stimulates O2not dissimilarly from normoxia. Hypoxic hypometabolism is likely toreflect a regulated process of depression of thermogenesis, with nolimitation in cellular O2availability. 相似文献
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Effects of hypoxia or hyperoxia on the lung of the chick embryo 总被引:1,自引:0,他引:1
Newborn mammals in chronic hypoxia or hyperoxia experience, respectively, an increase or decrease in lung weight:body weight ratios, possibly because of the mechanical effect on the lung accompanying the ventilatory response. Because the avian lung does not expand or contract with the breathing cycle, we asked whether or not qualitatively similar changes could be observed in the lung of chick embryos incubated in hypoxic or hyperoxic conditions. Hypoxic embryos (10% O2, days 14-18) were smaller than controls incubated in normoxia, with higher hematocrit values and larger lung weight:body weight ratios (both wet and dry). Both the total pulmonary DNA (reflecting the cellular component) and the DNA concentration were decreased in hypoxia. Hyperoxic embryos (50% O2, days 7-18 or days 14-18) had lower hematocrit values and smaller dry lung weight:body weight ratios than controls, with similar DNA concentrations. In general, the differences from controls were more apparent in those embryos hyperoxic from day 14 to 18 of incubation than from day 7 to 18. We conclude that changes in lung weights qualitatively similar to those occurring in the chronically hypoxic or hyperoxic newborn mammal can also be observed in the hypoxic or hyperoxic chick embryo, suggesting that they are not necessarily caused by changes in mechanical stretch on the lung. 相似文献
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Jacopo P. Mortola Kathryn Wills Teresa Trippenbach Khalid Al Awam 《Comparative biochemistry and physiology. Part A, Molecular & integrative physiology》2010,156(3):301-371
In the chick embryo at day 3, gas exchange occurs by diffusion and oxygen consumption (V?O2) does not depend on the cardiovascular convection of O2. Whether or not this is the case in hypoxia is not known and represents the aim of the study. The heart of chicken embryos at 72 h (stage HH18) was filmed through a window of the eggshell by a camera attached to a microscope. Stroke volume was estimated from the changes in heart silhouette between systole and diastole. V?O2was measured by a closed system methodology. In normoxia, a decrease in temperature (T) from 39 to 31 °C had parallel depressant effects on V?O2and HR. At 39 °C, a progressive decrease in O2 lowered V?O2; HR was maintained until the O2 threshold of ~ 15%. In severe hypoxia (4% O2) V?O2and HR were, respectively, ~ 12% and ~ 62% of normoxia. At 32 °C the hypoxic threshold for HR was significantly lower. During constant hypoxia (7% O2) V?O2did not respond to T, while the HR response was preserved. Stroke volume changed little with changes in T or O2, except at 6 and 4% O2, when it decreased by ~ 20 and 30%. In embryos growth-retarded because of incubation in chronic hypoxia, V?O2and HR responses to T and hypoxia were similar to those of normal embryos. We conclude that in the early embryo during hypoxia cardiovascular O2 convection is not responsible for the drop in V?O2. The generalised hypometabolic response, in combination with the extremely small cardiac V?O2, probably explains the minor effects of hypoxia on cardiac activity. 相似文献
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Long-term respiratory effects of neonatal hypoxia in the rat 总被引:5,自引:0,他引:5
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Fluid dynamic factors in tracheal pressure measurement 总被引:3,自引:0,他引:3