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81.
Jin Woo Park Sang Kyoon Kim Taslim Ahmed Al-Hilal Ok Cheol Jeon Hyun Tae Moon Youngro Byun 《Biotechnology and Bioprocess Engineering》2010,15(1):66-75
Advances in biotechnology, gene manipulation, and protein engineering for macromolecule drugs, such as insulin, parathyroid
hormone (PTH), calcitonin, human growth hormone, erythropoietin (EPO), and peptide YY (PYY) allow commercial production in
large scale for diverse therapeutic uses. Other macromolecules, such as mucopolysaccharide heparin, have expanded markets
through improvements in their pharmacokinetic and pharmacological effects. However, most products are available only as injectable
forms and are limited to patients with no alternative therapeutic choices. Orally available macromolecule formulations are
still unmet needs for improving patient compliance and expanding administration paradigms and indications. Oral delivery technologies
including carrier systems, absorption enhancers, protease inhibitors, and modification by conjugating transporter or receptor
recognition molecules have been developed and some are undergoing clinical studies. In this review, we discuss major obstacles
for oral absorption of macromolecule drugs and summarize recent strategies to overcome the huddles related to enhancing intestinal
permeation. 相似文献
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Jeong-Whun Kim Gwang Lee Seung-Min Moon Myung-June Park Sung Kyu Hong Young-Hwan Ahn Kyoung-Rae Kim Man-Jeong Paik 《Metabolomics : Official journal of the Metabolomic Society》2010,6(2):202-206
Metabolomic analysis of urinary amino acids (AAs) from patients with bladder cancer was performed by gas chromatography–mass
spectrometry. The β-aminoisobutyric acid (P < 0.05) and pyroglutamic acid (P < 0.03) levels among 21 AAs had relatively low P-values in the cancer group. The distorted star pattern of the cancer group was different from the heneicosagonal shape of
the control mean. The present metabolomic screening combined with star pattern recognition method as clinical monitoring tool
might be useful for the visual discrimination of bladder cancer group from normal group. 相似文献
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GORI,encoding the WD40 domain protein,is required for pollen tube germination and elongation in rice
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Park Jung Ha Moon Ji Hyun Kim Hyeon Ju Kong Mi Hee Oh Bumjo Kim Sunyoung Oh Yun Hwan 《Sleep and biological rhythms》2023,21(1):51-58
Sleep and Biological Rhythms - Determining whether weekend catch-up sleep (CUS) is related to high risk of depression in the general middle-aged population in Korea. This study is a cross-sectional... 相似文献