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51.
The invertebrate fauna of the nests of three seabird species, black-legged kittiwakes (Rissa tridactyla), common eider (Somateria mollissima) and glaucous gull (Larus hyperboreus), were sampled in Kongsfjorden, Spitsbergen, Svalbard. The invertebrate community was species poor, consisting predominantly
of the flea, Mioctenopsylla arctica arctica (Insecta: Siphonaptera), but with six species of oribatid mite (Acari: Oribatida), Diapterobates notatus, Oribatula tibialis, Ameronothrus lineatus, Hermannia reticulata, Trichoribates trimaculatus and Ceratoppia bipilis, plus an occasional mesostigmatid mite. No Collembola or ticks (Acari: Ixodidae) were observed. With the exception of M. arctica arctica, the fauna of seabird nests consisted of opportunistic microarthropod species rather than specialised nest-dwelling or bird
parasitic species. Species diversity of soil oribatid mites was greater in nests of the common eider than compared to nests
of the black-legged kittiwake, which may be related to the ground nesting behaviour of the common eiders. No rare or unusual
microarthropod species for Svalbard were found in the seabird nests. The contentions that nests may facilitate microarthropod
colonisation of High Arctic regions via bird phoresy by providing a high-quality habitat at the point of arrival, or that
there might be a specialised microarthropod fauna exploiting this habitat, were not supported in this study. These are amongst
the first data on the microarthropod community of seabird nests in the High Arctic. 相似文献
52.
The principal function of isoprene biosynthesis in plants remains unclear, but emission rates are positively correlated with temperature and light, supporting a role for isoprene in maintaining photosynthesis under transient heat and light stress from sunflecks. Isoprene production is also inversely correlated with CO(2) concentrations, implying that rising CO(2) may reduce the functional importance of isoprene. To understand the importance of isoprene in maintaining photosynthesis during sunflecks, we used RNAi technology to suppress isoprene production in poplar seedlings and compared the responses of these transgenic plants to wild-type and empty-vector control plants. We grew isoprene-emitting and non-emitting trees at low (190 ppm) and high (590 ppm) CO(2) concentrations and compared their photosynthetic responses to short, transient periods of high light and temperature, as well as their photosynthetic thermal response at constant light. While there was little difference between emitting and non-emitting plants in their photosynthetic responses to simulated sunflecks at high CO(2), isoprene-emitting trees grown at low CO(2) had significantly greater photosynthetic sunfleck tolerance than non-emitting plants. Net photosynthesis at 42°C was 50% lower in non-emitters than in isoprene-emitting trees at low CO(2), but only 22% lower at high CO(2). Dark respiration rates were significantly higher in non-emitting poplar from low CO(2), but there was no difference between isoprene-emitting and non-emitting lines at high CO(2). We propose that isoprene biosynthesis may have evolved at low CO(2) concentrations, where its physiological effect is greatest, and that rising CO(2) will reduce the functional benefit of isoprene in the near future. 相似文献
53.
54.
Blood vessels are commonly studied in isolation to define their mechanical and biological properties under controlled conditions. While sections of the wall are sometimes tested, vessels are most often attached to needles and examined in their natural cylindrical configuration where combinations of internal pressure and axial force can be applied to mimic in vivo conditions. Attachments to needles, however, constrain natural vessel response, resulting in a complex state of deformation that is not easily determined. As a result, measurements are usually limited to the midsection of a specimen where end effects do not extend and the deformation is homogeneous. To our knowledge, however, the boundaries of this uninfluenced midsection region have not been explored. The objective of this study was to define the extent of these end effects as a function of vessel geometry and material properties, loading conditions, and needle diameter. A computational fiber framework was used to model the response of a nonlinear anisotropic cylindrical tube, constrained radially at its ends, under conditions of axial extension and internal pressure. Individual fiber constitutive response was defined using a Fung-type strain energy function. While quantitative results depend on specific parameter values, simulations demonstrate that axial stretch is always highest near the constraint and reduces to a minimum in the uninfluenced midsection region. Circumferential stretch displays the opposite behavior. As a general rule, the length of the region disturbed by a needle constraint increases with the difference between the diameter of the needle and the equilibrium diameter of the blood vessel for the imposed loading conditions. The reported findings increase the understanding of specimen deformation in isolated vessel experiments, specifically defining considerations important to identifying a midsection region appropriate for measurement. 相似文献
55.
Paulo Cesar Gomes Bibiana Monson de Souza Nathalia Baptista Dias Patrícia Brigatte Danilo Mourelle Helen Andrade Arcuri Marcia Perez dos Santos Cabrera Rodrigo Guerino Stabeli João Ruggiero Neto Mario Sergio Palma 《Biochimica et Biophysica Acta (BBA)/General Subjects》2014
Background
The peptide Paulistine was isolated from the venom of wasp Polybia paulista. This peptide exists under a natural equilibrium between the forms: oxidised — with an intra-molecular disulphide bridge; and reduced — in which the thiol groups of the cysteine residues do not form the disulphide bridge. The biological activities of both forms of the peptide are unknown up to now.Methods
Both forms of Paulistine were synthesised and the thiol groups of the reduced form were protected with the acetamidemethyl group [Acm-Paulistine] to prevent re-oxidation. The structure/activity relationships of the two forms were investigated, taking into account the importance of the disulphide bridge.Results
Paulistine has a more compact structure, while Acm-Paulistine has a more expanded conformation. Bioassays reported that Paulistine caused hyperalgesia by interacting with the receptors of lipid mediators involved in the cyclooxygenase type II pathway, while Acm-Paullistine also caused hyperalgesia, but mediated by receptors involved in the participation of prostanoids in the cyclooxygenase type II pathway.Conclusion
The acetamidemethylation of the thiol groups of cysteine residues caused small structural changes, which in turn may have affected some physicochemical properties of the Paulistine. Thus, the dissociation of the hyperalgesy from the edematogenic effect when the actions of Paulistine and Acm-Paulistine are compared to each other may be resulting from the influence of the introduction of Acm-group in the structure of Paulistine.General significance
The peptides Paulistine and Acm-Paulistine may be used as interesting tools to investigate the mechanisms of pain and inflammation in future studies. 相似文献56.
57.
58.
Cancer mortality following radium treatment for uterine bleeding 总被引:3,自引:0,他引:3
P D Inskip R R Monson J K Wagoner M Stovall F G Davis R A Kleinerman J D Boice 《Radiation research》1990,123(3):331-344
Cancer mortality in relation to radiation dose was evaluated among 4153 women treated with intrauterine radium (226Ra) capsules for benign gynecologic bleeding disorders between 1925 and 1965. Average follow up was 26.5 years (maximum = 59.9 years). Overall, 2763 deaths were observed versus 2687 expected based on U.S. mortality rates [standardized mortality ratio (SMR) = 1.03]. Deaths due to cancer, however, were increased (SMR = 1.30), especially cancers of organs close to the radiation source. For organs receiving greater than 5 Gy, excess mortality of 100 to 110% was noted for cancers of the uterus and bladder 10 or more years following irradiation, while a deficit was seen for cancer of the cervix, one of the few malignancies not previously shown to be caused by ionizing radiation. Part of the excess of uterine cancer, however, may have been due to the underlying gynecologic disorders being treated. Among cancers of organs receiving average or local doses of 1 to 4 Gy, excesses of 30 to 100% were found for leukemia and cancers of the colon and genital organs other than uterus; no excess was seen for rectal or bone cancer. Among organs typically receiving 0.1 to 0.3 Gy, a deficit was recorded for cancers of the liver, gall bladder, and bile ducts combined, death due to stomach cancer occurred at close to the expected rate, a 30% excess was noted for kidney cancer (based on eight deaths), and there was a 60% excess of pancreatic cancer among 10-year survivors, but little evidence of dose-response. Estimates of the excess relative risk per Gray were 0.006 for uterus, 0.4 for other genital organs, 0.5 for colon, 0.2 for bladder, and 1.9 for leukemia. Contrary to findings for other populations treated by pelvic irradiation, a deficit of breast cancer was not observed (SMR = 1.0). Dose to the ovaries (median, 2.3 Gy) may have been insufficient to protect against breast cancer. For organs receiving greater than 1 Gy, cancer mortality remained elevated for more than 30 years, supporting the notion that radiation damage persists for many years after exposure. 相似文献
59.
The effects of increased hay‐to‐grain ratio on behavior,metabolic health measures,and fecal bacterial communities in four Masai giraffe (Giraffa camelopardalis tippelskirchi) at Cleveland Metroparks Zoo
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60.
Monson C. B.; Patterson S. L.; Horowitz J. M.; Oyama J. 《Journal of applied physiology》1989,67(1):383-389
To determine the effect of hypergravity acclimation on thermoregulation, core temperature (Tc), tail temperature (Tt), and O2 consumption (VO2) were measured in control rats (raised at 1 G) and in rats acclimated to 2.1 G. When the animals were exposed to a low ambient temperature of 9 degrees C, concurrently with a hypergravic field of 2.1 G, Tc of rats raised at 1 G fell markedly by approximately 6 degrees C (to 30.8 +/- 0.6 degrees C) while that of the rats raised at 2.1 G remained relatively constant (falling only approximately 1 degree C to 36.4 +/- 0.3 degrees C). Thus prior acclimation to a 2.1-G field enabled rats to maintain Tc when cold exposed in a 2.1-G field. To maintain Tc, thermogenic mechanisms were successfully activated in the 2.1-G-acclimated rats as shown by measurements of VO2. In contrast, VO2 measurements showed that rats reared at 1 G and then cold exposed at 2.1 G did not activate thermogenic mechanisms sufficiently to prevent a fall in Tc. In other experiments, rats acclimated to either 1 or 2.1 G were found to lack the ability to maintain their Tc when exposed to a 5.8-G field or when exposed to prolonged cold exposure at 1 G. Results are interpreted as showing that when placed in a 2.1-G field, rats acclimated to 2.1 G can more closely maintain their Tc near 37 degrees C when cold exposed than can rats acclimated to 1 G. However, this enhanced regulatory ability of 2.1-G-acclimated rats over 1.0-G-acclimated rats is restricted to 2.1-G fields and is not observed in 1.0- and 5.8-G fields. 相似文献