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Samantha J. Imberger Christopher J. Walsh Edward Tsyrlin David G. Kerr Monica Tewman 《Biodiversity and Conservation》2016,25(8):1465-1480
With climate change set to increase the frequency and severity of drought in many parts of the world, there is a need to better understand the effects of drying on stream ecosystems. We investigated the long-term effects of drought on two amphipod taxa Paramoera fontana (Pontogeneiidae) and Austrogammarus australis (Paramelitidae) and macroinvertebrate assemblage structure through an analysis of 13 years of data collected from four forested stream reaches (Victoria, Australia). Abundances of A. australis and P. fontana in the lower reach of Lyrebird Creek declined to zero following surficial streambed drying. Similar declines in abundances were not observed in Sassafras Creek or the two headwater springs, which continued to flow throughout the drought. P. fontana was detected again in the lower reach of Lyrebird Creek 12 months after the final cease-to-flow, however A. australis remained undetected 5 years later, despite an upstream source population within 2 km. Both the entire and shredder macroinvertebrate assemblage structure in Sassafras Creek and the lower reach of Lyrebird Creek shifted significantly pre- and post-surficial streambed drying in the lower reach of Lyrebird Creek. Despite signs of recovery following a return to more average flows, assemblage composition remained considerably different. The substantial differences in the recovery of the two species indicates varying resistance and resilience traits. The failure of A. australis to recolonize after 5 years indicates an absence of any significant resistance or resilience traits. In contrast, the rapid re-colonization of P. fontana may indicate poor resistance traits, but strong resilience traits. The sensitivity of A. australis to cease-to-flow events points to the need to carefully manage water extraction to protect this threatened species. The effective management of macroinvertebrate assemblages in the face of drought requires a clear understanding of their response to drying, the conservation of refugia and the minimization of additional stressors which reduce ecosystem resilience. 相似文献
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Mahendra Rai Avinash P. Ingle Swapnil Gaikwad Felipe Hering Padovani Monica Alves 《Critical reviews in biotechnology》2016,36(5):777-787
Nanotechnology is the creation and use of materials and devices on the same scale as molecules and intracellular structures, typically less than 100?nm in size. It is an emerging science and has made its way into pharmaceuticals to significantly improve the delivery and efficacy of drugs in a number of therapeutic areas, due to development of various nanoparticle-based products. In recent years, there has been increasing evidence that nanotechnology can help to overcome many of the ocular diseases and hence researchers are keenly interested in this science. Nanomedicines offer promise as viable alternatives to conventional drops, gels or ointments to improve drug delivery to the eye. Because of their small size, they are well tolerated, thus preventing washout, increase bioavailability and also help in specific drug delivery. This review describes the application of nanotechnology in the control of human diseases with special emphasis on various eye and ocular surfaces diseases. 相似文献
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Antonino Natalello P. Patrizia Mangione Sofia Giorgetti Riccardo Porcari Loredana Marchese Irene Zorzoli Annalisa Relini Diletta Ami Giulia Faravelli Maurizia Valli Monica Stoppini Silvia M. Doglia Vittorio Bellotti Sara Raimondi 《The Journal of biological chemistry》2016,291(18):9678-9689
The amyloidogenic variant of β2-microglobulin, D76N, can readily convert into genuine fibrils under physiological conditions and primes in vitro the fibrillogenesis of the wild-type β2-microglobulin. By Fourier transformed infrared spectroscopy, we have demonstrated that the amyloid transformation of wild-type β2-microglobulin can be induced by the variant only after its complete fibrillar conversion. Our current findings are consistent with preliminary data in which we have shown a seeding effect of fibrils formed from D76N or the natural truncated form of β2-microglobulin lacking the first six N-terminal residues. Interestingly, the hybrid wild-type/variant fibrillar material acquired a thermodynamic stability similar to that of homogenous D76N β2-microglobulin fibrils and significantly higher than the wild-type homogeneous fibrils prepared at neutral pH in the presence of 20% trifluoroethanol. These results suggest that the surface of D76N β2-microglobulin fibrils can favor the transition of the wild-type protein into an amyloid conformation leading to a rapid integration into fibrils. The chaperone crystallin, which is a mild modulator of the lag phase of the variant fibrillogenesis, potently inhibits fibril elongation of the wild-type even once it is absorbed on D76N β2-microglobulin fibrils. 相似文献
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Invasive aquatic plants typically reproduce vegetatively, but there have been conflicting hypotheses of invasive aquatic yellow flag iris dispersing primarily by seed versus rhizome fragmentation. We performed genetic analysis of 20 aquatic yellow flag iris populations across the Pacific Northwest, USA, with leaf tissue taken from plants between 2 and 5 m apart. We found 167 unique genotypes in 171 plants, and we never found genetically identical plants from different populations. We found that 99.1 % of seed is viable. Our results support that this obligately outcrossing invasive disperses almost entirely by seed, not rhizome fragmentation. We found no significant relationship between genetic and geographic distance across the Pacific Northwest, suggesting recent long distance dispersal and/or multiple founding events. Bayesian analysis shows the presence of two major genotypic clusters within our collections which also suggests more than one distinct genetic source for the invasion. These processes have led to genetically distinct populations that can be geographically close. Our findings are unusual for an aquatic invasive, and inform yellow flag iris managers of two things: (1) to limit dispersal, development of mature seed in the field should be prevented; and (2) if classical biological control is proposed, an agent guild that limits seed production would be effective for managing most dispersal. 相似文献