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1.
Widespread occurrence of AP in amyloidotic tissues. An immunohistochemical observation 总被引:1,自引:0,他引:1
T Shirahama M Skinner J D Sipe A S Cohen 《Virchows Archiv. B, Cell pathology including molecular pathology》1985,48(3):197-206
Plasma (P)-component of amyloid (AP or SAP), while not an integral part of the amyloid fibril, has been considered to be intimately associated with virtually every different type of amyloid. In the present study, we evaluated the distribution of AP in the organs frequently involved in two forms of human systemic amyloidosis (AA and AF) and in mouse AA amyloidosis, by use of immunohistochemistry with anti-AP. Although the amyloid deposits generally showed moderate reactions with anti-AP, they were not always clearly distinguished from the surrounding non-amyloid tissue elements which often stained as well. The basement membrane often showed even stronger reaction to anti-AP than the adjacent amyloid deposits, and liver sections demonstrated such a high overall reaction to anti-AP that the anti-AP reaction on the amyloid deposits was often obscurred. The present results suggest that the binding between AP and the amyloid fibril may not be monospecific, that AP by this technique occurs rather widely throughout the body, and therefore that anti-AP may not be considered as specific a marker for amyloid deposits in immunohistochemical and perhaps other studies as well. 相似文献
2.
Hostile intercommunity relations, including attacking and killing extra-community infants of both sexes have occurred at most
wild chimpanzee sites. We describe three recent cases of intercommunity attacks on infants committed by members of the Ngogo
chimpanzee community in Kibale National Park, Uganda. Two of the attacks resulted in confirmed infanticides while a third
attack probably resulted in the infant's death. In common with previous accounts of chimpanzee infanticides, the attacks described
here occurred during boundary patrols outside the Ngogo community's usual range, adult and adolescent males were the main
participants, one infant was cannibalized after being killed, and the victims’ mothers did not accompany the attacking party
back to the Ngogo range. However, the patrol parties during each infanticide were larger than before and included females
from the Ngogo community. Our observations indirectly support both the range expansion and imbalance of power hypotheses,
which address why and under which conditions chimpanzee intercommunity encounters lead to aggression. These cases of intercommunity
infanticide add to the growing database of the phenomenon in wild chimpanzees. 相似文献
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IN addition to its well known antiviral activity, interferon has recently been shown to inhibit the multiplication of tumour and mammalian cells in cell culture1–6. We report here the inhibition by interferon of DNA synthesis induced in mouse spleen lymphocytes by the non-viral stimuli phytohaemagglutinin (PHA) and allogeneic lymphocytes. These findings are in accord with our contention that interferon affects cell function and, furthermore, they suggest that by acting on lymphocytes, interferon plays a role in the immunological response of the host. 相似文献
9.
B Rayner M Matsukura F Morvan J S Cohen J L Imbach 《Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie》1989,310(3):61-64
Oligonucleotide analogs consisting exclusively of alpha-anomeric deoxynucleoside units bridged with phosphorothioate linkages have been synthesized and tested in vitro as antiviral agents against human immunodeficiency virus (HIV) in human T cells. Two 28-mers, an homopolymer alpha-S-dC28 and an oligomer alpha-S-anti-rev complementary to the initiation site of the regulatory viral gene rev exhibited antiviral activities comparable to those reported for the corresponding beta-anomeric phosphorothioate analogs. In contrast, a nuclease-resistant homopolymer, alpha-dC28 was inactive. Their preliminary results would indicate that the origin of oligonucleotide phosphorothioate anti-HIV activity is not exclusively correlated with their higher nuclease resistance. 相似文献
10.
CHLOROPLASTS are more permeable to amino-acids1,2 than are cell membranes3 and also discriminate between their optical isomers2. This has led to the suggestion that the passage of amino-acids through the limiting membranes of chloroplasts is facilitated by carriers2. Using the additional criteria of saturation and competition, we support this suggestion and show that at least two carriers are probably involved. 相似文献