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111.
Saleh Al-Quraishy Mostafa A. Abdel-Maksoud Esam M. Al-Shaebi Mohamed A. Dkhil 《Saudi Journal of Biological Sciences》2021,28(2):1374-1379
Malaria is a lethal parasitic disease affecting over two hundred million people worldwide and kills almost half a million people per year. Until now, there is no curative treatment for this disease that has a substantial morbidity. The available chemotherapeutic agents are unable to completely control the infection with the continuous appearance of drug resistance. Consequently, the search for new therapeutic agents with high safety profiles and low side effects is of paramount importance. Several natural products have been investigated and proven to have antimalarial effects either in vivo or in vitro. A large number of plants have been studied globally for their antimalarial activities. However, studies that have been conducted in this field in Saudi Arabia are not enough. This article presents global and local research on the need for novel natural antimalarial agents with a particular emphasis on studies involving plants from Saudi Arabian flora. 相似文献
112.
K.N. Sunil Kumar K.G. Divya M. Senthilkumar S.G. Sreelekshmi Hady M. El-Sheikh Mohamed A. El-Sheikh Abdullah Al-Ghamdi Bander Al-Munqedhi 《Saudi Journal of Biological Sciences》2021,28(2):1239-1245
Loranthaceae family includes hemiparasitic members which are seen invading a wide range of commercial crops. Helicanthes elasticus (Desv.) Danser is very common on mango trees. Though parasitic in nature, this mistletoe is also medicinally important as fetoprotective, against vesicular calculi and kidney infections. This study is an attempt to document macro-microscopical features of parasitic root, fruit and host-mistletoe tissue interaction in the haustorium of H. elasticus growing on mango stems. Collection, preservation, sectioning, staining and photomicrography of the root, fruit and host-mistletoe union were done as per standard methodologies of anatomical studies. Though there is resemblance to the normal roots in morphology as well as anatomy, the microscopic finding of large number of branched stone cells in the roots is interesting. The morpho-anatomical features recorded would help in understanding the infection biology of this mistletoe. The eradication during the earlier stages of its establishment from seed or from the root creeping over the surface of the host can help in controlling this parasite infection on commercially important host plants. 相似文献
113.
Doaa Kirat Mohamed Hamada Amira Moustafa Taku Miyasho 《Saudi Journal of Biological Sciences》2021,28(1):693-706
The quantification, localization, production, function, and regulation of irisin/FNDC5 in camel species have not been previously studied. The objective of this study was to detect the irisin content in Arabian camel blood and tissues and study the gene expression of FNDC5 and PGC-1α in camel skeletal muscles and white adipose tissue depots under basal conditions. To monitor if exercise influences blood and tissue irisin protein levels as well as FNDC5 and PGC-1α gene expression levels, we analyzed irisin concentrations in the serum, skeletal muscles (soleus and gastrocnemius), and white adipose tissues (hump, subcutaneous, visceral, epididymal, and perirenal) in both control (n = 6) and exercised group (n = 6) using ELISA and determined the cellular localization of irisin/FNDC5 and the mRNA levels of FNDC5 and PGC-1α in skeletal muscles and adipose tissues via immunohistochemistry and real-time PCR, respectively. The possible regulatory roles of exercise on some hormones and metabolites as well as the detection of links between serum irisin and other circulating hormones (insulin, leptin, and cortisol) and metabolites (glucose, free fatty acids, triglycerides, and ATP) were explored for the first time in camels. Our results indicated that exercise induces tissue-specific regulation of the camel irisin, FNDC5, and PGC-1α levels, which subsequently regulates the circulating irisin level. Significant associations were detected between the levels of irisin/FNDC5/PGC-1α in camels and the metabolic and hormonal responses to exercise. Our study suggested that irisin regulates, or is regulated by, glucose, FFA, insulin, leptin, and cortisol in camels. The novel results of the present study will serve as baseline data for camels. 相似文献
114.
115.
Heavy metals in the soil and ground water have endangered our environment and human bodies by direct or indirect pathways. Currently, bioremediation is a developing process that offers the possibility to destroy various contaminants using natural biological activity. Biopolymers are industrially attractive because of their capability of lowering transition metal ion concentrations to parts per billion, they are widely available, and they are environmentally safe. This paper deals with the preparation of an ethylamine-modified biopolymer (chitosan) and carbon from biowaste (rice husk) composite beads (EAM-CCRCB) for metal ion removal. The prepared adsorbent was used for the adsorption of hexavalent chromium ions from aqueous solutions. The activation and surface properties of the adsorbent were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and Brunauer-Emmett-Teller (BET) analyses. The effect of process variables such as initial metal ion concentration, adsorbent dosage, and pH of the solution on the performance of percentage removal and adsorption capacity were studied. Various isotherm and kinetic models were fitted with experimental data to describe the solute interaction and nature of adsorption with the adsorbent through batch studies. Mass thermodynamic parameters were determined. Regeneration studies were attempted to check the stability and activity of the adsorbent. 相似文献
116.
Siva S. Panda Mohamed A. Ibrahim Said A. El‐Feky Alan R. Katritzky 《Journal of peptide science》2013,19(2):110-117
Nα‐Boc‐Nim‐(4‐toluenesulfonyl‐l ‐histidylbenzotriazole) enables convenient acylation of N‐, O‐, S‐, and C‐nucleophiles with no detectable racemization. We report efficient syntheses of novel histidine‐containing di‐, tri‐, and tetra‐peptides and models for the preparation of potentially biologically active histidine N‐, O‐, S‐, and C‐conjugates. Copyright © 2013 European Peptide Society and John Wiley & Sons, Ltd. 相似文献
117.
Solid state production of polygalacturonase and xylanase by Trichoderma species using cantaloupe and watermelon rinds 总被引:1,自引:0,他引:1
Saleh A. Mohamed Abdulrahman L. Al-Malki Jalaluddin A. Khan Saleh A. Kabli Saleh M. Al-Garni 《Journal of microbiology (Seoul, Korea)》2013,51(5):605-611
Different solid state fermentation (SSF) sources were tested such as cantaloupe and watermelon rinds, orange and banana peels, for the production of polygalacturonase (PG) and xylanase (Xyl) by Trichoderma harzianum and Trichoderma virens. The maximum production of both PG and Xyl were obtained by T. harzianum and T. virnes grown on cantaloupe and watermelon rinds, respectively. Time course, moisture content, temperature, pH, supplementation with carbon and nitrogen sources were optimized to achieve the maximum production of both PG and Xyl of T. harzianum and T. virens using cantaloupe and watermelon rinds, respectively. The maximum production of PG and Xyl of T. harzianum and T. virens was recorded at 4–5 days of incubation, 50–66% moisture, temperature 28–35°C and pH 6–7. The influence of supplementary carbon and nitrogen sources was studied. For T. harzianum, lactose enhanced PG activity from 87 to 120 units/g solid, where starch and maltose enhanced Xyl activity from 40 to 55–60 units/g solid for T. virnes. Among the nitrogen sources, ammonium sulphate, ammonium nitrate, yeast extract and urea increased PG activity from 90 to 110–113 units/g solid for T. harzianum. Similarly, ammonium chloride, ammonium sulphate and yeast extract increased Xyl activity from 45 to 55–70 units/g solid for T. virens. 相似文献
118.
Abdel‐Maaboud I. Mohamed Osama H. Abdelmageed Hesham Salem Dalia M. Nagy Mahmoud A. Omar 《Luminescence》2013,28(3):345-354
A validated simple and sensitive spectrofluorimetric method was developed for the determination of chlorpromazine hydrochloride, promethazine hydrochloride, trifluperazine hydrochloride, thioridazine hydrochloride, perazine maleate and oxomemazine. The method was based on condensation of malonic acid/acetic anhydride (MAA) under the catalytic effect of the tertiary amine moiety of the studied phenothiazines to provide a deep yellow to brown colour with green florescence. Relative fluorescence intensity of the products was measured at λexc 398 nm and λem 432 nm. Different variables affecting the reaction were studied and optimized. The method was successfully applied for the determination of the studied drugs in commercial dosage forms. The lower detection limits allowed the application of this method for the determination of the compounds in plasma as an example of a biological fluid. In addition, the method was considered specific for the determination of tertiary amines in the presence of primary and secondary amines; as a result, it was deemed suitable for the determination of the cited drugs in the presence of their degradation products resulting from N‐dealkylation or oxidation of the corresponding sulphoxides or sulphones. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
119.
Mohamed F. Abdel-Megeed Mohamed A. Saleh Youssef L. Aly Ibrahim M. Abdo 《Nucleosides, nucleotides & nucleic acids》2013,32(9-10):1985-1996
Abstract A series of some new acetylated S-glycosides of 2-thioxoquinazolin-4-ones, their thiono analogues and 3,1-benzothazin-2,4-dithione derivatives, including a D-glucose and a D-galactose derivatives and a D-xylose, and an L-arabinose derivatives have been synthesized. The conformation and configuration of these carbohydrate derivatives were determined by analysing their 1H and 13C NMR chemical shifts and coupling constants. The biological activity of these compounds has been studied. 相似文献
120.
Mohamed I. Elzagheid Mikko Oivanen Karel D. Klika Bryan C. N. M. Jones Richard Cosstick Harri Lönnberg 《Nucleosides, nucleotides & nucleic acids》2013,32(9):2093-2108
Abstract The course of hydrolysis of 3′-deoxy-3′-thioinosylyl-(3′ → 5′)-uridine (IspU) has been followed by HPLC over a wide pH-range. Two reactions of the internucleosidic thiophosphate linkage compete: (i) cleavage yielding thioinosine monophosphates and uridine, and (ii) isomerization to the 2′,5′-isomer of IspU. Under very acidic conditions, even acid-catalyzed depurination of the inosine moiety is observed. The stability of the thiophosphate linkage and the mechanisms of its rupture are discussed. 相似文献