全文获取类型
收费全文 | 756篇 |
免费 | 37篇 |
专业分类
793篇 |
出版年
2024年 | 1篇 |
2023年 | 10篇 |
2022年 | 29篇 |
2021年 | 43篇 |
2020年 | 19篇 |
2019年 | 32篇 |
2018年 | 34篇 |
2017年 | 24篇 |
2016年 | 41篇 |
2015年 | 48篇 |
2014年 | 48篇 |
2013年 | 68篇 |
2012年 | 61篇 |
2011年 | 63篇 |
2010年 | 29篇 |
2009年 | 26篇 |
2008年 | 31篇 |
2007年 | 31篇 |
2006年 | 39篇 |
2005年 | 26篇 |
2004年 | 18篇 |
2003年 | 17篇 |
2002年 | 9篇 |
2001年 | 9篇 |
2000年 | 7篇 |
1999年 | 4篇 |
1998年 | 2篇 |
1997年 | 4篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1994年 | 3篇 |
1993年 | 1篇 |
1990年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1977年 | 1篇 |
1975年 | 1篇 |
1972年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有793条查询结果,搜索用时 0 毫秒
771.
772.
773.
Mohamad Ahmad Khedr 《Archives Of Phytopathology And Plant Protection》2016,49(5-6):95-110
In the research for alternative tools and botanical products to control Spodoptera littoralis (Boisduval) (Lepidoptera: Noctuidae). Sesamum indicum (L.) (Lamiales: Pedaliaceae) oil was assayed as an ovicide. The mortality increased with existence of fatty acids. Chemical analysis of S. indicum oil using GLC analysis showed palmitic acid as the major fatty acid (51.27%), while the major hydrocarbon and sterols were found to be heneicosane (58.63%) and β-sitosterol (2.60%), respectively. Generally, the values of LC50s indicated that one-day-old egg masses are more susceptible than three-day-old eggs. Also, the leaf dip technique is more efficient than the spraying one. Results showed several features of chorionic surface deformation treated with sesame and KZ oils than control using scanning electron microscopy. Meanwhile, the tested oils caused significant reduction in both total soluble protein and transaminase enzymes as compared to control. Additionally, the oils elongated the incubation period and larval duration than control. 相似文献
774.
775.
Ismail Noor Zafirah Adebayo Ismail Abiola Mohamed Wan Ahmad Syazani Mohamad Zain Nur Nadhirah Arsad Hasni 《Molecular biology reports》2021,48(11):7361-7370
Molecular Biology Reports - C. vespertiliomis extracts were evaluated for antiproliferative and apoptosis effect on breast cancer (MCF7) cells. The leaves extracts were analysed for its... 相似文献
776.
Xu J Kussmaul W Kurnik PB Al-Ahdav M Pelleg A 《American journal of physiology. Regulatory, integrative and comparative physiology》2005,288(3):R651-R655
The mechanism of extracellular ATP-triggered vagal depressor reflex was further studied in a closed-chest canine model. Adenosine and ATP were administered individually in equimolar doses (0.01-1.0 mumol/kg) into the right coronary artery (RCA) and left circumflex coronary artery (LCA). When administered into the RCA, adenosine and ATP exerted an identical and relatively small negative chronotropic effect on sinus node automaticity; the time to peak negative chronotropic effect was >/=7 s. When administered into the LCA, adenosine had no effect on sinus node automaticity, whereas ATP markedly suppressed sinus node automaticity. This effect of ATP 1) reached its peak in <2 s after its administration, 2) was short lasting, and 3) was completely abolished by either intravenous administration of the muscarinic cholinergic blocker atropine (0.2 mg/kg) or intra-LCA administration of 2',3'-O-(2,4,6-trinitrophenyl)-ATP (TNP-ATP), a potent P2X(2/3) purinergic receptor (P2X(2/3)R) antagonist, but not by diinosine pentaphosphate (Ip(5)I), a potent inhibitor of P2X(1)R and P2X(3)R. Repetitive administrations of ATP were not associated with reduced effects, indicative of receptor desensitization, thereby excluding the involvement of the rapidly desensitized P2X(1)R in the action of ATP. It was concluded that ATP triggers a cardio-cardiac vagal depressor reflex by activating P2X(2/3)R located on vagal sensory nerve terminals localized in the left ventricle. Because these terminals mediate vasovagal syncope, these data could suggest a mechanistic role of extracellular ATP in this syndrome and, in addition, give further support to the hypothesis that endogenous ATP released from ischemic myocytes is a mediator of atropine-sensitive bradyarrhythmias associated with left ventricular myocardial infarction. 相似文献
777.
778.
779.
Seyedeh Laili Mohebbi-Nozar Wan Ruslan Ismail Mohamad Pauzi Zakaria Mohammad Seddiq Mortazavi Mohammad Ali Zahed Ali Jahanlu 《人类与生态风险评估》2014,20(5):1164-1176
Levels of polychlorinated biphenyls (PCBs) congeners and dichlorodiphenyltrichloroethane and its metabolites (DDTs) were measured in 18 species of fish, crab, shrimp, and bivalve samples collected from the northern region of the Persian Gulf in Iran. The levels of ∑PCBs varied from 259.92 ± 31.04 ng/g to 1648.88 ± 176.96 ng/g in lipid weight. CB118 showed the highest concentration. ∑DDT variations ranged from ND to 570.45 ± 806.74 ng/g in lipid weight. Health risk was assessed by estimating both dietary intakes and screening values (SVs). Daily intake levels were much lower than the Food and Agriculture Organization (FAO)/World Health Organization (WHO) standards for PCBs and DDTs. Based on an average bodyweight of 73 kg and consumption rates of 0.055 kg/person. day, the SVs for the carcinogen and non-carcinogen effects of PCB and DDT were calculated. Average concentrations of PCBs and DDTs showed that the levels of PCBs exceeded the established SV for carcinogens. This finding suggests the need to enhance risk management regarding seafood consumption through public advisory. 相似文献
780.
Michelle P. Christie Pavla Simerská Freda E.-C. Jen Waleed M. Hussein Mohamad F. M. Rawi Lauren E. Hartley-Tassell Christopher J. Day Michael P. Jennings Istvan Toth 《PloS one》2014,9(4)
Glycosylation of biopharmaceuticals can mediate cell specific delivery by targeting carbohydrate receptors. Additionally, glycosylation can improve the physico-chemical (drug-like) properties of peptide based drug candidates. The main purpose of this study was to examine if glycosylation of the peptide enkephalin could facilitate its binding to the carbohydrate receptor, asialoglycoprotein. Firstly, we described the one-pot enzymatic galactosylation of lactose modified enkephalin in the presence of uridine-5′-diphosphogalactose 4-epimerase and lipopolysaccharyl α-1,4-galactosyltransferase. Stability experiments using human plasma and Caco-2 cell homogenates showed that glycosylation considerably improved the stability of enkephalin (at least 60% remained stable after a 2 hr incubation at 37°C). In vitro permeability experiments using Caco-2 cells revealed that the permeability of mono- and trisaccharide conjugated enkephalins was 14 and 28 times higher, respectively, than that of enkephalin alone (Papp 3.1×10−8 cm/s). By the methods of surface plasmon resonance and molecular modeling, we demonstrated that the enzymatic glycosylation of enkephalin enabled binding the asialoglycoprotein receptor. The addition of a trisaccharide moiety to enkephalin improved the binding of enkephalin to the asialoglycoprotein receptor two fold (KD = 91 µM). The docking scores from molecular modeling showed that the binding modes and affinities of the glycosylated enkephalin derivatives to the asialoglycoprotein receptor complemented the results from the surface plasmon resonance experiments. 相似文献