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131.
Srinivasa T. Reddy Mohamad Navab G.M. Anantharamaiah Alan M. Fogelman 《Biochimica et Biophysica Acta (BBA)/Molecular and Cell Biology of Lipids》2014,1841(1):162-167
Despite strong evidence that HDL-cholesterol levels predict atherosclerotic events in a population, attempts at using an HDL-based treatment strategy have not yet been successful. Most of the efforts to date have focused on raising plasma HDL-cholesterol levels. This brief review focuses on a different strategy, which is based on the use of 18-amino acid apoA-I mimetic peptides. The story of these peptides spans decades and illustrates the remarkable complexity of HDL-based treatment strategies, but suggests that such a strategy may still be successful. 相似文献
132.
Mukhtar Salihu Anka Latiffah Hassan Siti Khairani-Bejo Mohamed Abidin Zainal Ramlan bin Mohamad Annas Salleh Azri Adzhar 《PloS one》2014,9(9)
Bovine brucellosis was first reported in Peninsular Malaysia in 1950. A subsequent survey conducted in the country revealed that the disease was widespread. Current knowledge on the potential risk factors for brucellosis occurrence on cattle farms in Malaysia is lacking. Therefore, we conducted a case-control study to identify the potential herd-level risk factors for bovine brucellosis occurrence in four states in the country, namely Kelantan, Pahang, Selangor and Negeri Sembilan. Thirty-five cases and 36 controls of herds were selected where data on farm management, biosecurity, medical history and public health were collected. Multivariable logistic regression identified that Brucella seropositive herds were more likely to; have some interaction with wildlife (OR 8.9, 95% CI = 1.59–50.05); originated from farms where multiple species such as buffalo/others (OR 41.8, 95% CI = 3.94–443.19) and goat/sheep (OR 8.9, 95%Cl = 1.10–71.83) were reared, practice extensive production system (OR 13.6, 95% CI 1.31–140.24) and have had episodes of abortion in the past (OR 51.8, 95% CI = 4.54–590.90) when compared to seronegative herds. Considering the lack of information on the epidemiology of bovine brucellosis in peninsular Malaysia and absence of information on preventing the inception or spread of the disease, this report could contribute to the on-going area-wise national brucellosis eradication program. 相似文献
133.
Jiejie Li Benjamin H. Staiger Jessica L. Henty-Ridilla Mohamad Abu-Abied Einat Sadot Laurent Blanchoin Christopher J. Staiger 《Molecular biology of the cell》2014,25(8):1263-1275
A network of individual filaments that undergoes incessant remodeling through a process known as stochastic dynamics comprises the cortical actin cytoskeleton in plant epidermal cells. From images at high spatial and temporal resolution, it has been inferred that the regulation of filament barbed ends plays a central role in choreographing actin organization and turnover. How this occurs at a molecular level, whether different populations of ends exist in the array, and how individual filament behavior correlates with the overall architecture of the array are unknown. Here we develop an experimental system to modulate the levels of heterodimeric capping protein (CP) and examine the consequences for actin dynamics, architecture, and cell expansion. Significantly, we find that all phenotypes are the opposite for CP-overexpression (OX) cells compared with a previously characterized cp-knockdown line. Specifically, CP OX lines have fewer filament–filament annealing events, as well as reduced filament lengths and lifetimes. Further, cp-knockdown and OX lines demonstrate the existence of a subpopulation of filament ends sensitive to CP concentration. Finally, CP levels correlate with the biological process of axial cell expansion; for example, epidermal cells from hypocotyls with reduced CP are longer than wild-type cells, whereas CP OX lines have shorter cells. On the basis of these and other genetic studies in this model system, we hypothesize that filament length and lifetime positively correlate with the extent of axial cell expansion in dark-grown hypocotyls. 相似文献
134.
Hormozgan Province plays a vital role in fishery, petroleum, and industrial activities in southern Iran. However, no comprehensive studies on organic pollution have been performed. PCBs and PAHs were analyzed in surface sediments from areas receiving industrial (nine sites), river (one site), and urban (two sites) effluents. The sediment samples were collected in March and September 2010 (in dry and wet seasons) at the highest tidal time. The overall pollution level of PCBs ranged from 2.5 ± 0.8 to 462.0 ± 206.7 ng/g dry weight. CB153 congener dominated in most of the sediment samples. Congener profiles of PCBs showed close similarity with formulations of commercial products such as Aroclor 1260 and 1254 g. A wide range of 55.3 to 1231.6 ng/g dry weight was detected for ∑PAHs. Results of PCA and PCA-MLR tests confirmed both petrogenic and pyrogenic origins for PAH pollution. The higher means of ∑PAHs and ∑PCBs in industrial and urban wastewaters were found near the shore, evidencing the role of these wastewaters in the PAH and PCB contamination in Hormozgan sediment. The concentrations of PAHs and PCBs in detected hotspots exceed the U.S. NOAA sediment quality guidelines. 相似文献
135.
Fatemeh Sadeghsoltani Parisa Hassanpour Mir‑Meghdad Safari Sanya Haiaty Reza Rahbarghazi Mohamad Rahmati Ali Mota 《Journal of cellular physiology》2024,239(2):e31185
Angiogenesis is a complex process that involves the expansion of the pre-existing vascular plexus to enhance oxygen and nutrient delivery and is stimulated by various factors, including hypoxia. Since the process of angiogenesis requires a lot of energy, mitochondria play an important role in regulating and promoting this phenomenon. Besides their roles as an oxidative metabolism base, mitochondria are potential bioenergetics organelles to maintain cellular homeostasis via sensing alteration in oxygen levels. Under hypoxic conditions, mitochondria can regulate angiogenesis through different factors. It has been indicated that unidirectional and bidirectional exchange of mitochondria or their related byproducts between the cells is orchestrated via different intercellular mechanisms such as tunneling nanotubes, extracellular vesicles, and gap junctions to maintain the cell homeostasis. Even though, the transfer of mitochondria is one possible mechanism by which cells can promote and regulate the process of angiogenesis under reperfusion/ischemia injury. Despite the existence of a close relationship between mitochondrial donation and angiogenic response in different cell types, the precise molecular mechanisms associated with this phenomenon remain unclear. Here, we aimed to highlight the possible role of mitochondria concerning angiogenesis, especially the role of mitochondrial transport and the possible relation of this transfer with autophagy, the housekeeping phenomenon of cells, and angiogenesis. 相似文献
136.
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138.
Naeema A. Akbar Abdullah M. Assiri Omima I. Shabouni Osama M. Alwafi Rajaa Al-Raddadi Mohamad H. Alzahrani Esam I. Azhar Ashraf Amir Abdullah M. Aljiffri Abdulhakeem O. Althaqafi 《PLoS neglected tropical diseases》2020,14(11)
Rapid urbanization, global trade, and the exceptionally great numbers of worldwide visitors during Hajj and Umrah have all placed the Kingdom of Saudi Arabia at a significant risk of introducing several vector-borne tropical diseases, such as dengue fever virus (DENV) infection. In this study we estimated DENV infection cost of illness (COI) in Saudi Arabia in the period 2013–2017, by processing national data including all declared cases recorded in referral centers in the western region, being the endemic region of the country. Using a statistically validated predictive model that was built on a representative sample of 717 laboratory-confirmed cases of DENV infection, direct costs, due to care-related expenditures, were estimated by applying the predictive equation to national data. However, indirect costs, which are due to productivity loss, were estimated using the human capital model based on gross domestic product adjusted for invalidity duration. Further, under-reporting was adjusted by using an expansion factor EF = 3. We observed highest estimated costs in 2016 with over US$168.5 Million total costs, including direct (US$29.0 Million) and indirect (US$139.5 Million) costs, for a total 4415 confirmed cases. The total DENV COI for the five years was estimated as US$551.0 Million for a total 15,369 patients (59.7%) out of 25,745 declared cases, resulting in an average cost of US$11 947.6 by patient. Depending on the year, productivity years loss costs accounted for 63.3% to 83.8% of the estimated total costs. Dengue has a substantial local economic burden that costs US$110.2 Million per year, stressing the urgent need for an effective national prevention strategy to perform considerable cost-savings besides reducing morbidity. 相似文献
139.
Polysaccharide production by Aureobasidium pullulans: factors affecting polysaccharide formation 总被引:1,自引:0,他引:1
S. M. Badr-Eldin O. M. El-Tayeb H. G. El-Masry F. H. A. Mohamad O. A. Abd El-Rahman 《World journal of microbiology & biotechnology》1994,10(4):423-426
Aureobasidium pullulans NRRL 6220 synthesized polysaccharide most actively in media containing sucrose, fructose or maltose with (NH4)2SO4 (0.6 g/l) or ammonium acetate giving greatest yields of the polysaccharide. With (NH4)2SO4 at 1.2 g/l, production of polysaccharide was decreased considerably. Polysaccharide production was highest with an initial pH of 6.5 while biomass formation was better below an initial pH of 5.5. Optimum phosphate concentration for polysaccharide production was 0.03 m.S.M. Badr-Eldin, H.G. El-Masry and O.A. Abd El-Rahman are with the Microbial Chemistry Department, National Research Center, Dokki, Cairo, Egypt; F.H.A. Mohamad is with the Chemical Engineering and Pilot Plant Department, National Research Center, Dokki, Cairo, Egypt. O.M. El-Tayeb is with the Microbiology Department, Faculty of Pharmacy, Cairo University, Egypt. 相似文献
140.
Leila Hatami-Baroogh Shahnaz Razavi Hamid Zarkesh-Esfahani Marziyeh Tavalaee Somayeh Tanhaei Kamran Ghaedi Mohamad Reza Deemeh Farzaneh Rabiee Mohammad Hossein Nasr-Esfahani 《Reproductive biology and endocrinology : RB&E》2010,8(1):17