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Gomathi Ram Shalini Devraj Abitha Benson 《International journal of phytoremediation》2019,21(13):1375-1383
AbstractThis study reports the combined use of a rhamnolipid type biosurfactant (BS) along with phytoremediation and bioaugmentation (BA) for bioremediation of hydrocarbon-contaminated soils. Bacterial isolates obtained from hydrocarbon contaminated soil were screened for rhamnolipid production and isolate BS18, identified as Shewanella seohaensis, was selected for bioremediation experiments. Growth of BS18 in mineral salt medium (MSM) with diesel oil as the carbon source showed a maximum biomass of 8.2?g L?1, rhamnolipid production of 2.2?mg g?1 cell dry weight, surface tension reduction of 28.6?mN/m and emulsification potential (EI24%) of 65.6. Characterization of rhamnolipid based on Fourier transmittance infrared (FTIR) analysis confirmed the presence of OH, CH2/CH3, C=O, and COO stretching vibrations, respectively, which are distinctive features of rhamnolipid type BSs. In bioremediation experiments, the lowest hydrocarbon concentration of 2.1?mg g?1 of soil for non-sterilized soil and 4.3?mg g?1 of soil for sterilized soil was recorded in the combined application of rhamnolipid, phytoremediation, and BA. This treatment also yielded the highest hydrocarbon degrading bacterial population (6.4 Log Cfu g?1 of soil), highest plant biomass (8.3?g dry weight plant?1), and the highest hydrocarbon uptake (512.3?mg Kg?1 of plant). 相似文献
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Youssef Fouani Luisa Kirchhof Laura Stanicek Guillermo Luxn Andreas W Heumüller Andrea Knau Ariane Fischer Kavi Devraj David John Philipp Neumann Albrecht Bindereif Reinier A Boon Stefan Liebner Ilka Wittig Carolin Mogler Madina Karimova Stefanie Dimmeler Nicolas Ja 《EMBO reports》2022,23(6)
Vascular integrity is essential for organ homeostasis to prevent edema formation and infiltration of inflammatory cells. Long non‐coding RNAs (lncRNAs) are important regulators of gene expression and often expressed in a cell type‐specific manner. By screening for endothelial‐enriched lncRNAs, we identified the undescribed lncRNA NTRAS to control endothelial cell functions. Silencing of NTRAS induces endothelial cell dysfunction in vitro and increases vascular permeability and lethality in mice. Biochemical analysis revealed that NTRAS, through its CA‐dinucleotide repeat motif, sequesters the splicing regulator hnRNPL to control alternative splicing of tight junction protein 1 (TJP1; also named zona occludens 1, ZO‐1) pre‐mRNA. Deletion of the hnRNPL binding motif in mice (Ntras ∆CA/∆CA) significantly repressed TJP1 exon 20 usage, favoring expression of the TJP1α‐ isoform, which augments permeability of the endothelial monolayer. Ntras ∆CA/∆CA mice further showed reduced retinal vessel growth and increased vascular permeability and myocarditis. In summary, this study demonstrates that NTRAS is an essential gatekeeper of vascular integrity. 相似文献
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Devadas B Selness SR Xing L Madsen HM Marrufo LD Shieh H Messing DM Yang JZ Morgan HM Anderson GD Webb EG Zhang J Devraj RV Monahan JB 《Bioorganic & medicinal chemistry letters》2011,21(13):3856-3860
A novel series of highly potent and selective p38 MAP kinase inhibitors was developed originating from a substituted N-aryl-6-pyrimidinone scaffold. SAR studies coupled with in vivo evaluations in rat arthritis model culminated in the identification of 10 with excellent oral efficacy. Compound 10 exhibited a significantly enhanced dissolution rate compared to 1, translating to a high oral bioavailability (>90%) in rat. In animal studies 10 inhibited LPS-stimulated production of tumor necrosis factor-α in a dose-dependent manner and demonstrated robust efficacy comparable to dexamethasone in a rat streptococcal cell wall-induced arthritis model. 相似文献
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Selness SR Boehm TL Walker JK Devadas B Durley RC Kurumbail R Shieh H Xing L Hepperle M Rucker PV Jerome KD Benson AG Marrufo LD Madsen HM Hitchcock J Owen TJ Christie L Promo MA Hickory BS Alvira E Naing W Blevis-Bal R Devraj RV Messing D Schindler JF Hirsch J Saabye M Bonar S Webb E Anderson G Monahan JB 《Bioorganic & medicinal chemistry letters》2011,21(13):4059-4065
A series of N-aryl pyridinone inhibitors of p38 mitogen activated protein (MAP) kinase were designed and prepared based on the screening hit SC-25028 (1) and structural comparisons to VX-745 (5). The focus of the investigation targeted the dependence of potency and metabolic stability on the benzyloxy connectivity, the role of the C-6 position and the substitution pattern on the N-phenyl ring. Further optimization produced the highly selective and potent pyridinones 2 and 3. These inhibitors exhibited activity in both acute and chronic models of inflammation. 相似文献
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Hughes RO Rogier DJ Devraj R Zheng C Cao G Feng H Xia M Anand R Xing L Glenn J Zhang K Covington M Morton PA Hutzler JM Davis JW Scherle P Baribaud F Bahinski A Mo ZL Newton R Metcalf B Xue CB 《Bioorganic & medicinal chemistry letters》2011,21(9):2626-2630
We describe the systematic optimization, focused on the improvement of CV-TI, of a series of CCR2 antagonists. This work resulted in the identification of 10 (((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxy-tetrahydro-2H-pyran-4-ylamino)cyclopentyl)(4-(5-(trifluoromethyl)pyridazin-3-yl)piperazin-1-yl)methanone) which possessed a low projected human dose 35-45 mg BID and a CV-TI = 3800-fold. 相似文献
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Brian C. Shook Devraj Chakravarty J. Kent Barbay Aihua Wang Kristi Leonard Vernon Alford Mark T. Powell Stefanie Rassnick Robert H. Scannevin Karen Carroll Nathaniel Wallace Jeffrey Crooke Mark Ault Lisa Lampron Lori Westover Kenneth Rhodes Paul F. Jackson 《Bioorganic & medicinal chemistry letters》2013,23(9):2688-2691
A novel series of benzyl substituted thieno[2,3-d]pyrimidines were identified as potent A2A receptor antagonists. Several five- and six-membered heterocyclic replacements for the optimized methylfuran were explored. Select compounds effectively reverse catalepsy in mice when dosed orally. 相似文献
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Association of sex, age and ABO-Rh(D) type with unexpected antibodies among multitransfused thalassemia patients in Bikaner, Rajasthan, India
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Shailendra Vashisth Kunal Purohit Devraj Ary Arun Bharti 《Asia-Pacific Journal of Blood Types and Genes》2018,2(3):155-158
The thalassemia has become a sensitive issue for clinical and public health owing to the morbidity and mortality caused and potential risks associated with multiple transfusions. Here, a blood bank based cross sectional analytical study was carried out during the period of three months from January 2017 to March 2017, among transfusion dependent beta thalassemia major patients. ABO-Rh(D) blood grouping and screening for unexpected red cell antibodies (other than anti-A and anti-B antibodies) were performed on a Immucor Galileo Neo System (fully automated immunohematology analyzer). Out of 56 patients, 37 (66%) were males and 19 (34%) were females with a male to female ratio of 1.95:1. Two cases (3.6%) were detected positive by antibody screening. Alloimmunization was statistically analyzed on the basis of age, sex and subjects'' ABO-Rh blood group. This study underlines the need for unexpected antibody screening among thalassemic patients receiving blood transfusion therapy. 相似文献
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