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91.
Due to their significant role in food industry, sucrose isomerases are good candidates for rational protein engineering. Hence,
specific modifications in order to modify substrate affinity and selectivity, product specificity but also to adapt their
catalytic properties to particular industrial process conditions, is interesting. Our work on the structural studies of the
sucrose isomerase, MutB, which presents the first structural data available on a trehalulose synthase and the first experimental
data on complexed forms of sucrose isomerases represents a significant advance in the understanding of these enzymes. In this
review we give an overview of what is known on biochemical properties and structural aspects of different sucrose isomerases
in particular those reported from bacteria. 相似文献
92.
H Elmahmoudi F Ben-Lakhal W Elborji A Jlizi K Zahra R Sassi M Zorgan B Meddeb A Elgaaied Ben Ammar E Gouider 《Diagnostic pathology》2012,7(1):92
ABSTRACT: Inherited factor VII (FVII) deficiency is a rare disorder characterized by a bleeding phenotype varying from mild to severe. To date, more than 200 mutations have been described along the F7 gene encoding for FVII. The aim of this study was the identification of genetic defects underlying FVII deficiency in 10 patients belonging to eight unrelated families of the North provinces from Tunisia. Mutation detection was performed by sequencing the whole F7 gene coding region, exon-intron boundaries and about 400 bp of the promoter region. We identified 5 mutations in five unrelated families; the novel p.F328Y mutation and the reported mutations: p.R304Q, p.M298I, IVS1aG > A and nt1005C > T. For the remaining 5 patients we didn't identified any mutations using PCR/Sequencing protocol. In conclusion, this study represents the first comprehensive molecular series of FVII deficiency affected patients in Tunisia from the North. We will try in the future to continue the molecular study for Tunisian patients from Center and South provinces in order to have a complete idea about the FVII deficiency mutational profile in our country. Virtual slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1288044089753085. 相似文献