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141.
Oxygen depletion induced dormancy in Mycobacterium smegmatis 总被引:2,自引:0,他引:2
142.
M Modell 《BMJ (Clinical research ed.)》1993,307(6908):849-852
The identification of the gene for cystic fibrosis has led to the possibility of population based screening for carriers of cystic fibrosis to identify couples at risk of having an affected child. Pilot studies have shown that screening is feasible and does not cause untoward anxiety, though the uptake of testing varies considerably with the setting and method of invitation. Screening offered at times when individuals (and health professionals) perceive it as directly relevant will probably gradually become established in the United Kingdom. This review examines the role of general practice in genetic carrier screening as exemplified by cystic fibrosis. General practice has a pivotal role from the beginning in providing individuals and couples with information, facilitating testing of patients'' relatives and of carriers identified by screening elsewhere (such as antenatal clinics), and offering testing in the context of reproduction. Screening for the cystic fibrosis gene will probably be followed by other genetic screening programmes. 相似文献
143.
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146.
Thirteen infants and children with adenovirus type 7 infection proved by virus isolation are described. High fever, cough and dyspnea were the most frequent findings; in infants under 1 year of age wheezing was common. Four patients required artificial ventilation. Lobar collapse, consolidation and hyperinflation were frequent radiologic findings. None of the symptoms responded to antibiotic therapy or bronchodilator drugs. Three patients died (mortality rate of 23%). Pathologic findings were compatible with adenovirus type 7 pneumonia, and were characterized by a necrotizing bronchitis and bronchiolitis, patchy alveolar fibrinopurulent exudate and hyaline membrane formation. Some intra-alveolar epithelial cells showed strikingly abnormal nuclei and rare typical halo-outlined intranuclear inclusions were seen. Only one of eight survivors had evidence of significant chronic chest disease. 相似文献
147.
Bernadette Boutard Marie-Louise Bouillant Jean Chopin Philippe Lebreton 《Biochemical Systematics and Ecology》1973,1(3):133-140
The flavonoid patterns of twenty-three species of Fluviales (= Helobieae) were determined. Flavonols and pro-anthocyanidins are uncommon and trihydroxy derivatives are absent. In contrast, flavones (luteolin and chrysoeriol derivatives) are common, often as C-glycosides (Alismataceae, Butomaceae, Potamogetonaceae). From a taxonomic point of view the results suggest that the Fluviales can be divided into two groups: Potamogetonaceae. Zosteraceae, Ruppiaceae, Zanichelliaceae and Juncaginaceae forming the first, and Hydrocharitaceae, Butomaceae. Alismataceae and Aponogetonaceae the second. This arrangement agrees for the most part with the views of Emberger and Takhtajan.
Résumé
Le contenu flavonique de 23 Fluviales (= Hélobiées) a été analysé. Flavonols et leuco-anthocyanes sont rares, les dérivés phényl-trihydroxylés absents. Les flavones, par contre, sont fréquentes (lutéoline, chrysoériol). notamment sous forme de C-glycosides (Alismatacées, Butomacées, Potamogétonacées). D'un point de vue taxinomique, les résultats permettent de regrouper, d'une part Potamogétonacées, Zostéracées, Ruppiacées. Zanichelliacées et Juncaginacées; d'autre part Hydrocharitacées, Butomacées, Alismatacées et Aponogétonacées. Cette proposition s'accorde dans ses grandes lignes avec les rues des botanistes Emberger et Takhtajan. 相似文献148.
A common point mutation in the tyrosine hydroxylase gene in autosomal recessive L-DOPA-responsive dystonia in the Dutch population 总被引:4,自引:0,他引:4
L. P. W. J. van den Heuvel Bernadette Luiten J. A. M. Smeitink Johanneke F. de Rijk-van Andel Keith Hyland Gerry C. H. Steenbergen-Spanjers R. J. T. Janssen R. A. Wevers 《Human genetics》1998,102(6):644-646
This report concerns one new mutation in the tyrosine hydroxylase (TH) gene in three patients originating from three unrelated
Dutch families with autosomal recessive L-DOPA-responsive dystonia (DRD). In this study, all exons of the TH gene were amplified
by the polymerase chain reaction and subjected to analyses by single-strand conformation polymorphism. An aberrant migration
pattern was observed for exon 6 of the TH gene in all patients. Direct sequencing of the coding region of exon 6 revealed
the presence of one novel missense mutation. An a698g transition resulted in the substitution of the evolutionary conserved
arginine 233 by a histidine (R233H). All patients were homozygous for the mutation. This new mutation in the TH gene was confirmed
by restriction enzyme analysis with the restriction enzyme HhaI. Thus, a high proportion of defective TH alleles may be R233H in The Netherlands.
Received: 25 July 1997 / Accepted: 10 February 1998 相似文献
149.
Moderate alcohol consumption is associated with better endothelial function: a cross sectional study
Keiko Suzuki Mitchell SV Elkind Bernadette Boden-Albala Zhezhen Jin Grace Berry Marco R Di Tullio Ralph L Sacco Shunichi Homma 《BMC cardiovascular disorders》2009,9(1):1-5
Background
Natural heterologous valved conduits with a diameter greater than 22 mm that can be used for right ventricular outflow tract reconstruction in adults are not commercially available. The purpose of this study was to measure by ultrasonography the maximum diameter of the distended jugular veins of horses and cattle, respectively, to identify a population of animals that would be suitable for post-mortem collection of jugular veins at sizes greater than 22 mm.Methods
The study population included 60 Warmblood horses, 25 Freiberger horses, 20 Brown Swiss cows, and 20 Holstein cows (including 10 Holstein and 10 Red Holstein). The maximum cross-sectional diameter of the distended jugular veins was measured at a location half-way between the mandibular angle and the thoracic inlet. The thoracic circumference (heart girth length) was used as a surrogate of body size. The jugular vein diameters of the different populations were compared by analysis of variance and the association between heart girth length and jugular vein diameter was determined in each of the four study populations by linear regression analysis.Results
There was considerable individual variation of jugular vein diameters within each of the four study populations. There was no statistically significant relationship between thoracic circumference and jugular vein diameter in any of the populations. The jugular vein diameters of Brown Swiss cows were significantly larger than those of any of the other populations. Warmblood horses had significantly larger jugular vein diameters compared to Freiberger horses.Conclusion
The results of this study suggest that the production of bovine or equine xenografts with diameters of greater than 22 mm would be feasible. Differences between species and breeds need to be considered. However, prediction of the jugular vein diameter based on breed and heart girth length in an individual animal is inaccurate. 相似文献150.
James R. Anderson Catherine Fritsch Bernadette Favre 《Primates; journal of primatology》1990,31(4):611-615
An adult femaleLemur catta and an adult femaleEulemur fulvus were given edible rewards for scratching. Both subjects learned to scratch in order to obtain the rewards, showed diminished
rates of scratching during periods of extinction, and learned to scratch preferentially with one foot when required. TheLemur catta subject was more responsive to the changing experimental conditions than theEulemur fulvus. The conditionability of scratching in primates does not appear to be directly related to the widespread occurrence of scratching
in simian social contexts. 相似文献