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排序方式: 共有442条查询结果,搜索用时 62 毫秒
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Belal Shohayeb Nicholas Rui Lim Uda Ho Zhiheng Xu Mirella Dottori Leonie Quinn Dominic Chi Hiung Ng 《Molecular neurobiology》2018,55(7):5409-5424
Genetic disruptions of spindle/centrosome-associated WD40-repeat protein 62 (WDR62) are causative for autosomal recessive primary microcephaly (MCPH) and a broader range of cortical malformations. Since the identification of WDR62 as encoded by the MCPH2 locus in 2010, recent studies that have deleted/depleted WDR62 in various animal models of cortical development have highlighted conserved functions in brain growth. Here, we provide a timely review of our current understanding of WDR62 contributions in the self-renewal, expansion and fate specification of neural stem and progenitor cells that are critical for neocortical development. Recent studies have revealed multiple functions for WDR62 in the regulation of spindle organization, mitotic progression and the duplication and biased inheritance of centrosomes during asymmetric divisions. We also discuss recently elaborated WDR62 interaction partners that include Aurora and c-Jun N-terminal kinases as part of complex signalling mechanisms that may define its neural functions. These studies provide new insights into the molecular and cellular processes that are required for brain formation and implicated in the genesis of primary microcephaly. 相似文献
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Aldo Andreani Silvia Burnelli Massimiliano Granaiola Alberto Leoni Alessandra Locatelli Rita Morigi Mirella Rambaldi Lucilla Varoli Laura Landi Cecilia Prata Francesco Vieceli Dalla Sega Cristiana Caliceti Robert H. Shoemaker 《Bioorganic & medicinal chemistry》2010,18(9):3004-3011
This paper reports the synthesis of new derivatives (formed by two indole systems separated by a central moiety) analogous of potent antitumor agents previously described. The activity of the bis-indoles bearing a pyridine core confirms the good result described in the previous paper and compound 4c was chosen for the first in vivo experiment (Hollow Fiber Assay). COMPARE analysis and structure–activity relationships were also considered. Contrary to data reported by other Authors, no correlations were found between antitumor activity and NQO1 induction. 相似文献
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Autoantibody signature in human ductal pancreatic adenocarcinoma 总被引:1,自引:0,他引:1
Tomaino B Cappello P Capello M Fredolini C Ponzetto A Novarino A Ciuffreda L Bertetto O De Angelis C Gaia E Salacone P Milella M Nisticò P Alessio M Chiarle R Giuffrida MG Giovarelli M Novelli F 《Journal of proteome research》2007,6(10):4025-4031
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by rapid progression, invasiveness, and resistance to treatment. It is the fourth leading cause of cancer death with a 2% 5-year survival rate. Biomarkers for its early detection are lacking. This study was designed to use a proteomics-based approach as a means of identifying antigens that elicit a humoral response in PDAC patients. Antibodies against PDAC-associated antigens are useful for early cancer diagnosis and therapy. Proteins from PDAC cell lines were separated by 2-DE, and the serum IgG reactivity of 70 PDAC patients, 40 healthy subjects (HS), 30 non-PDAC tumor patients, and 15 chronic pancreatitis (CP) patients was tested by Western blot analysis. Spots specifically recognized by PDAC sera and revealed by mass spectrometry corresponded to metabolic enzymes or cytoskeletal proteins. Most were up-regulated in PDAC tissues. Thus, it seems that metabolic enzymes and cytoskeletal proteins are specific targets of the humoral response during PDAC. The results of further studies of these serological-defined antigens could be of diagnostic and therapeutic significance in PDAC. 相似文献
110.
Bucci M 《Nature chemical biology》2007,3(1):13
Nestled in an atmosphere that resembles a national park, the Center for Molecular Biology of RNA at the University of California, Santa Cruz is fulfilling Harry Noller's vision of bringing together multidisciplinary researchers to solve problems that range from finding obscure RNAs to understanding the origin of life. 相似文献