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Weifeng He Yuan Gao Jing Zhou Yi Shi Dajing Xia Han-Ming Shen 《International journal of biological sciences》2022,18(12):4690
There is increasing amount of evidence indicating the close interplays between the replication cycle of SARS-CoV-2 and the autophagy-lysosome pathway in the host cells. While autophagy machinery is known to either assist or inhibit the viral replication process, the reciprocal effects of the SARS-CoV-2 on the autophagy-lysosome pathway have also been increasingly appreciated. More importantly, despite the disappointing results from the clinical trials of chloroquine and hydroxychloroquine in treatment of COVID-19, there is still ongoing effort in discovering new therapeutics targeting the autophagy-lysosome pathway. In this review, we provide an update-to-date summary of the interplays between the autophagy-lysosome pathway in the host cells and the pathogen SARS-CoV-2 at the molecular level, to highlight the prognostic value of autophagy markers in COVID-19 patients and to discuss the potential of developing novel therapeutic strategies for COVID-19 by targeting the autophagy-lysosome pathway. Thus, understanding the nature of such interactions between SARS-CoV-2 and the autophagy-lysosome pathway in the host cells is expected to provide novel strategies in battling against this global pandemic. 相似文献
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沿海快速城市化地区能值生态足迹变化分析 总被引:1,自引:0,他引:1
当前我国经济的快速发展和生态环境之间的矛盾日益显著,不利于城市可持续发展。生态足迹目前已成为普遍接受的可持续发展指标,选定生态足迹改进方法——能值生态足迹模型,以城市化地区厦门市为研究区进行计算分析,以期发现快速城市化过程中可能面对的问题。首次计算分析了厦门市1980年至2010年的能值生态足迹动态变化,并对其可持续发展进行了评价。结果表明,30年间厦门市人均生态足迹需求从1980年的8.6 ghm2持续增长至2010年的52.8 ghm2,而供给方面的人均生态承载力却从1980年的181.2 ghm2持续下降为47.5 ghm2,2009、2010年该市由生态盈余转为生态赤字。同时,从生态足迹组分及其比例来看,30年间化石燃料用地和建设用地的生态足迹增长迅速,二者对厦门市人均能值生态足迹变化贡献最大,并且成为2000年后总体足迹中所占比例最大的组分,各自占比超过20%。结果分析显示,厦门市开始面临逐渐加重的生态环境压力,需要开始重视其可持续发展。因此调整厦门市的产业结构和控制城市化发展非常必要。一方面,应该降低第二产业的比例,降低对化石能源的使用,同时促进第三产业的发展和第一产业的现代化,以此为城市提供更多的资源供给并降低资源需求,特别是化石能源的需求。 相似文献
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Yun-Ting He Xiao-Hong Huang Yue-Yi Fang Qing-Sheng Zeng Lai-De Li Le Luo Ying-Si Lai 《PLoS neglected tropical diseases》2022,16(5)
Clonorchiasis is an important food-borne parasitic disease caused by Clonorchis sinensis infection. The evaluation of long-term cost-effectiveness of control strategies is important for disease control and prevention. The present study aimed to assess the cost-effectiveness of the three recommended strategies (i.e., WHO, Chinese and Guangdong strategies) and different combinations of commonly used measures (i.e., preventive chemotherapy, information, education, and communication (IEC) and environmental improvement) on clonorchiasis. The study area, Fusha town in Guangdong Province, was a typical high endemic area in China. The analysis was based on a multi-group transmission model of C. sinensis infection. We set the intervention duration for 10 years and post-intervention period for 50 years. The corresponding costs and DALYs were estimated. Strategies with incremental cost-effectiveness ratios (ICERs) less than 1/5 of the willingness-to-pay threshold were identified as highly cost-effective strategies. The optimal control strategy was obtained using the next best comparator method. The ICERs of Guangdong strategy were $172 (95% CI: $143-$230) US for praziquantel and $106 (95% CI: $85-$143) US for albendazole, suggesting the highest cost-effectiveness among the three recommended strategies. For praziquantel, 470 sets of control strategies were identified as highly cost-effective strategies for achieving infection control (prevalence<5%). The optimal strategy consisted of chemotherapy targeted on at-risk population, IEC and environmental improvement, with coverages all being 100%, and with the ICER of $202 (95% CI: $168-$271) US. The results for transmission control (prevalence<1%) and albendazole were obtained with the same procedures. The findings may help to develop control policies for C. sinensis infection in high endemic areas. Moreover, the method adopted is applicable for assessment of optimal strategies in other endemic areas. 相似文献