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161.
Shuai Yu Chunping Miao Hong Song Yanqing Huang Wei Chen 《International journal of phytoremediation》2019,21(7):643-651
AbstractIncreased nitrogen and phosphorus pollution causes eutrophication in water bodies. Using aquatic plants to remove nutrients from water is an attractive phytoremediation. It is a cost-effective, environment-friendly, and efficient way that reduces water body eutrophication by the plant. It is important to choose suitable macrophytes to remove excess N and P under different nutrient conditions. In this study, six macrophyte species (Polygonum orientale, Juncus effuses, Iris pseudocorus, Phragmites australis, Iris sanguinea, Typha orientalis) were tested. Simulation experiment was conducted under five N and P levels. The removal rate, relative growth rate, and the dynamic nutrition concentration of cultivated solution were investigated. Of all the treatment, a 23–95% reduction in N removal and a 29–92% reduction in P removal were recorded. The results showed I. sanguinea is a promising species to treat various eutrophic waters and the other five species can be used specifically to treat certain types of water. The data provided a theoretical guidance to plant species selection for phytoremediation of polluted water bodies for the purpose of water quality improvement around the different reservoir in northern China. 相似文献
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Viktoriya S. Anokhina John D. McAnany Jessica H. Ciesla Thomas A. Hilimire Netty Santoso Hongyu Miao Benjamin L. Miller 《Bioorganic & medicinal chemistry》2019,27(13):2972-2977
Ribosomal frameshifting, a process whereby a translating ribosome is diverted from one reading frame to another on a contiguous mRNA, is an important regulatory mechanism in biology and an opportunity for therapeutic intervention in several human diseases. In HIV, ribosomal frameshifting controls the ratio of Gag and Gag-Pol, two polyproteins critical to the HIV life cycle. We have previously reported compounds able to selectively bind an RNA stemloop within the Gag-Pol mRNA; these compounds alter the production of Gag-Pol in a manner consistent with increased frameshifting. Importantly, they also display antiretroviral activity in human T-cells. Here, we describe new compounds with significantly reduced molecular weight, but with substantially maintained affinity and anti-HIV activity. These results suggest that development of more “ligand efficient” enhancers of ribosomal frameshifting is an achievable goal. 相似文献
164.
Qian Chen Tian Sun Jin Wang James Jia Yan‐Hua Yi Yu‐Xin Chen Yong Miao Zhi‐Qi Hu 《Journal of biochemical and molecular toxicology》2019,33(9)
Hydroxytyrosol (HT), a primary phenolic antioxidant in olive oil, can afford protection from oxidative stress (OS) in different cells, including skin cells. In particular, it regulates several inflammation‐associated processes as well as in improving the antioxidant defense system. However, there is no information about HT used in the treatment of hair loss. This work aimed at exploring the potential protective actions of HT against OS in rat dermal papilla cells. After treatment, the related expression of protein and messenger RNA were detected using morphological and molecular analyses. The results showed that HT significantly reduced intracellular reactive oxygen species level, apoptotic markers and inflammation induced by OS and enhanced cell survival by regulating autophagy. Furthermore, HT enhanced the secretion of hair growth factors in the anti‐inflammation process. These results suggest that HT has a significant protective ability against OS and encourage the use of this biological ingredient as a possible tool to prevent alopecia. 相似文献
165.
Xiao‐Li Wang Hua‐Fei Deng Ting Li Shu‐Ying Miao Zi‐Hui Xiao Mei‐Dong Liu Ke Liu Xian‐Zhong Xiao 《Journal of biochemical and molecular toxicology》2019,33(4)
Platelet activation contributes to organs failure in inflammation and plays an important role in endotoxemia. Clopidogrel inhibits platelet aggregation and activation. However, the role of clopidogrel in modulating inflammatory progression of endotoxemia remains largely unexplored. Therefore, we investigated the role of clopidogrel on the activation of platelet and leukocytes in lipopolysaccharide (LPS)‐induced inflammation in mice. Animals were treated with clopidogrel or vehicle before LPS induction. The expression of neutrophil‐platelet aggregates and platelet activation and tissue factor was determined. Immunofluorescence was used to analyze platelet‐leukocyte interactions and tissue factor (TF) expression on leukocytes. Clopidogrel pretreatment markedly decreased lung damage, inhibited platelet‐neutrophil aggregates and TF expression. In addition, clopidogrel reduced thrombocytopenia and affected the number of circulating white blood cell in endotoxemia mice. Moreover, clopidogrel also reduced platelet shedding of CD40L and CD62P in endotoxemic mice. Taken together, clopidogrel played an important role through reducing platelet activation and inflammatory process in endotoxemia. 相似文献
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Wenhao Miao Shupeng Ma Zhiwen Guo Haozhe Sun Xuemei Wang Yueming Lyu Xiangping Wang 《Journal of Plant Ecology》2022,15(2):385
恢复梯度上华中亚热带森林生物多样性、林分因子及功能特性对生物量、生产力的影响
草地群落上进行的控制实验大都发现生物多样性对生态系统功能有显著促进作用。然而,在天然林中,多样性与林分因子、群落功能特性的相对作用大小仍存在争议。本文在森林恢复梯度上,研究这3类因素对生物量和生产力的相对影响。我们在湖北神农架设置了处于不同恢复阶段的24块(600 m2)亚热 带森林样地,计算了林分生物量和生产力。选择5个关键的植物功能性状,并计算了群落的功能多样性(功能丰富度、功能均匀度和功能离散度)和性状的加权平均值(CWM)。使用一般线性模型(GLMs)、变异分离等方法探究林分因子(密度、林龄、群落最大树高等)、功能特性、物种和功能多样性对生物量和生产力的相对重要性。研究结果表明,随着森林恢复,林分生物量和生产力显著增加,群落物种丰富度显著增加,而功能离散度显著降低。变异分离结果表明,多样性对生物量和生产力的单独效应不显著,但可能通过与林分因子和功能特性的协同效应来影响生物量和生产力。总体而言,我们发现林分因子对亚热带森林生物量和生产力的影响最大,功能特性显著影响生产力,但不影响生物量。这些结果说明,在森林经营中,调整林分结构和群落物种特性是提高森林碳储量和固碳潜力的有效途径。 相似文献
169.
目的:观察比较BAY41-2272和己酮可可碱(PTX)这两种增强环磷酸鸟苷(cGMP)活性的物质对大鼠Thy-1诱导的进展性肾病模型的疗效,探讨肾纤维化治疗的新途径。方法:成功诱导Thy-1肾炎后,将大鼠分为四组:即肾纤维化组(RF组)、BAY 41-2272治疗组、PTX治疗组和对照组。治疗15周后,分别检测各组大鼠血清肌酐和尿蛋白排泄量,肾组织病理和免疫组化方法检测肾小球/小管间质基质堆积程度和ED1/PCNA阳性细胞数,检测肾小球和皮质转化生长因子TGF-β1、纤粘蛋白(fi- bronectin)、基质金属蛋白酶抑制物(TIMP-1)等蛋白能表达水平,ELISA方法检测肾小球/小管间质细胞的基础、刺激后cGMP水平。RT-PCR方法检测内皮细胞一氧化氮合成酶、α1/β1可溶性鸟苷酸环化酶mRNA水平。结果:观察结束时,BAY41-2272显著降低大鼠尿蛋白排泄和血肌酐水平,显著减轻肾小球/小管间质基质堆积程度,降低巨噬细胞浸润数目和TGF-β1、fibronectin表达水平,而PTX治疗仅产生轻微的变化。肾纤维化组大鼠的小管间质sGC mRNA、NO刺激的cGMP水平显著高于对照组,而肾小球的则较对照组降低;BAY41-2272治疗后肾小球/小管间质sGC mRNA、刺激后cGMP水平可显著提高,而PTX治疗的只有轻度提高而无统计学意义。结论:BAY41-2272治疗可显著改善肾组织NO-cGMP信号通路转导和cGMP的活性,可有效的延缓肾纤维化的进展,而PTX疗效则相对很弱。采用BAY41-2272提高cGMP活性的方案可能为肾纤维化提供新颖、极具前景的治疗策略。 相似文献
170.
Two bacterial strains,Pyl and Py4,have been tamed and isolated through long cultivation with polycyclic aromatic hydrocarbon-pyrene as the single carbon source.It has been proven that they are both highly-efficient pyrene degrading bacteria and both Bacillus sp..The pyrene degradation ability of separated Pyl,Py4 and the consortium of equal Pyl and Py4 was studied in this project.It is shown that pyrene degradation rates were 88% in 10hr by Py1,84% in 14hr by Py4,and 88% in 8hr by the consortium.It was also determined that the best degradation temperatures were 37℃ and pH 7.0 respectively.The influence of different nutrient substrates added in the degradation experiments was also studied.It was shown that sodium salicylate,sodium acetate and yeast exuact had obvious simulative effect,but glucose had no obvious effect. 相似文献