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11.
Marijn Rutgers Daniël BF Saris Wouter JA Dhert Laura B Creemers 《Arthritis research & therapy》2010,12(3):R114
Introduction
Intraarticular administration of autologous conditioned serum (ACS) recently demonstrated some clinical effectiveness in treatment of osteoarthritis (OA). The current study aims to evaluate the in vitro effects of ACS on cartilage proteoglycan (PG) metabolism, its composition and the effects on synovial fluid (SF) cytokine levels following intraarticular ACS administration. 相似文献12.
K. S. Volodin I. M. Minaev A. A. Rukhadze K. Z. Rukhadze K. F. Sergeichev 《Plasma Physics Reports》2009,35(1):50-53
The possibility of controlling the directional pattern of a multislot waveguide antenna with the help of a gas-discharge tube placed inside the waveguide was studied experimentally. Since the dielectric parameters of the waveguide depend on the plasma density in the discharge column, they can be controlled by varying the discharge current. The high efficiency of such plasma control was demonstrated experimentally: as the discharge current was varied from 0 to 200 mA, the antenna directional pattern turned by ~17°. 相似文献
13.
14.
A. D. Melnik N. N. Bakharev V. K. Gusev P. R. Goncharov G. S. Kurskiev V. B. Minaev Yu. V. Petrov N. V. Sakharov A. Yu. Telnova S. Yu. Tolstyakov F. V. Chernyshev P. B. Shchegolev 《Plasma Physics Reports》2017,43(8):805-817
Specific features of the energy distributions of fast ions during neutral beam injection at the Globus-М tokamak are considered. Different loss mechanisms that can lead to the formation of a specific shape of the energy spectrum of superthermal ions are analyzed. The effect of sawtooth oscillations on the loss of fast ions is discussed. 相似文献
15.
Anika I Tsuchida Michiel Beekhuizen Marieke C ‘t Hart Timothy RDJ Radstake Wouter JA Dhert Daniel BF Saris Gerjo JVM van Osch Laura B Creemers 《Arthritis research & therapy》2014,16(5)
Introduction
This study aimed to evaluate whether profiles of several soluble mediators in synovial fluid and cartilage tissue are pathology-dependent and how their production is related to in vitro tissue formation by chondrocytes from diseased and healthy tissue.Methods
Samples were obtained from donors without joint pathology (n = 39), with focal defects (n = 65) and osteoarthritis (n = 61). A multiplex bead assay (Luminex) was performed measuring up to 21 cytokines: Interleukin (IL)-1α, IL-1β, IL-1RA, IL-4, IL-6, IL-6Rα, IL-7, IL-8, IL-10, IL-13, tumor necrosis factor (TNF)α, Interferon (IFN)γ, oncostatin M (OSM), leukemia inhibitory factor (LIF), adiponectin, leptin, monocyte chemotactic factor (MCP)1, RANTES, basic fibroblast growth factor (bFGF), hepatocyte growth factor (HGF), vascular growth factor (VEGF).Results
In synovial fluid of patients with cartilage pathology, IL-6, IL-13, IFNγ and OSM levels were higher than in donors without joint pathology (P ≤0.001). IL-13, IFNγ and OSM were also different between donors with cartilage defects and OA (P <0.05). In cartilage tissue from debrided defects, VEGF was higher than in non-pathological or osteoarthritic joints (P ≤0.001). IL-1α, IL-6, TNFα and OSM concentrations (in ng/ml) were markedly higher in cartilage tissue than in synovial fluid (P <0.01). Culture of chondrocytes generally led to a massive induction of most cytokines (P <0.001). Although the release of inflammatory cytokines was also here dependent on the pathological condition (P <0.001) the actual profiles were different from tissue or synovial fluid and between non-expanded and expanded chondrocytes. Cartilage formation was lower by healthy unexpanded chondrocytes than by osteoarthritic or defect chondrocytes.Conclusions
Several pro-inflammatory, pro-angiogenic and pro-repair cytokines were elevated in joints with symptomatic cartilage defects and/or osteoarthritis, although different cytokines were elevated in synovial fluid compared to tissue or cells. Hence a clear molecular profile was evident dependent on disease status of the joint, which however changed in composition depending on the biological sample analysed. These alterations did not affect in vitro tissue formation with these chondrocytes, as this was at least as effective or even better compared to healthy chondrocytes. 相似文献16.
17.
Chimpanzee fetal G gamma and A gamma globin gene nucleotide sequences provide further evidence of gene conversions in hominine evolution 总被引:5,自引:0,他引:5
The fetal globin genes G gamma and A gamma from one chromosome of a
chimpanzee (Pan troglodytes) were sequenced and found to be closely similar
to the corresponding genes of man and the gorilla. These genes contain
identical promoter and termination signals and have exons 1 and 2 separated
by the conserved short intron 1 (122 bp) and exons 2 and 3 separated by the
more rapidly evolving, larger intron 2 (893 bp and 887 bp in chimpanzee G
gamma and A gamma, respectively). Each intron 2 has a stretch of simple
sequence DNA (TG)n serving possibly as a "hot spot" for recombination. The
two chimpanzee genes encode polypeptide chains that differ only at position
136 (glycine in G gamma and alanine in A gamma) and that are identical to
the corresponding human chains, which have aspartic acid at position 73 and
lysine at 104 in contrast to glycine and arginine at these respective
positions of the gorilla A gamma chain. Phylogenetic analysis by the
parsimony method revealed four silent (synonymous) base substitutions in
evolutionary descent of the chimpanzee G gamma and A gamma codons and none
in the human and gorilla codons. These Homininae (Pan, Homo, Gorilla)
coding sequences evolved at one-tenth the average mammalian rate for
nonsynonymous and one-fourth that for synonymous substitutions. Three
sequence regions that were affected by gene conversions between chimpanzee
G gamma and A gamma loci were identified: one extended 3' of the hot spot
with G gamma replaced by the A gamma sequence, another extended 5' of the
hot spot with A gamma replaced by G gamma, and the third conversion
extended from the 5' flanking to the 5' end of intron 2, with G gamma
replaced here by the A gamma sequence. A conversion similar to this third
one has occurred independently in the descent of the gorilla genes. The
four previously identified conversions, labeled C1-C4 (Scott et al. 1984),
were substantiated with the addition of the chimpanzee genes to our
analysis (C1 being shared by all three hominines and C2, C3, and C4 being
found only in humans). Thus, the fetal genes from all three of these
hominine species have been active in gene conversions during the descent of
each species.
相似文献
18.
I. M. Minaev A. A. Rukhadze P. A. Goryachkin V. A. Chernikov 《Plasma Physics Reports》2018,44(6):588-593
This work continues the series of studies of pulsed high-voltage discharges propagating over liquid surfaces in the presence of barriers. In this work, the influence of the barrier position relative to the air electrode on the discharge voltage in the stage of the completed discharge is analyzed. The effect of the water depth and barrier submersion depth on the propagation of a pulsed discharge is studied. 相似文献
19.
A. D. Iblyaminova G. F. Avdeeva P. N. Aruev N. N. Bakharev V. K. Gusev V. V. Zabrodsky G. S. Kurskiev V. B. Minaev I. V. Miroshnikov M. I. Patrov Yu. V. Petrov N. V. Sakharov S. Yu. Tolstyakov P. B. Shchegolev 《Plasma Physics Reports》2016,42(10):909-918
Radiation losses from the plasma of the Globus-M tokamak are studied by means of SPD silicon photodiodes developed at the Ioffe Institute, Russian Academy of Sciences. The results from measurements of radiation losses in regimes with ohmic and neutral beam injection heating of plasmas with different isotope compositions are presented. The dependence of the radiation loss power on the plasma current and plasma–wall distance is investigated. The radiation power in different spectral ranges is analyzed by means of an SPD spectrometric module. Results of measurements of radiation losses before and after tokamak vessel boronization are presented. The time evolution of the sensitivity of the SPD photodiode during its two-year exploitation in Globus-M is analyzed. 相似文献
20.
Yashin A. Yu. Bulanin V. V. Petrov A. V. Gusev V. K. Kurskiev G. S. Minaev V. B. Patrov M. I. Petrov Yu. V. 《Plasma Physics Reports》2020,46(7):683-688
Plasma Physics Reports - Here we report the results of the turbulence study in the high-confinement mode (H-mode) with and without edge localized modes (ELMs). The study was performed by the... 相似文献