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921.
Nazarpour Sima Ramezani Tehrani Fahimeh Amiri Mina Simbar Masoumeh Tohidi Maryam Bidhendi Yarandi Razieh Azizi Fereidoun 《Biological trace element research》2020,193(2):348-356
Biological Trace Element Research - Long-term use of hair dyes has potential effects on metal content in hair. However, little research dissects the specific distribution and composition variations... 相似文献
922.
Pantea Mohammadi Mina Zangeneh Hamid-Reza Mohammadi-Motlagh Fatemeh Khademi 《Reports of Biochemistry & Molecular Biology》2020,9(3):250
Background:Non-Hodgkin''s lymphomas comprise the most common hematological cancers worldwide and consist of a heterogenous group of malignancies affecting the lymphoid system. Treatment of non-Hodgkin’s lymphoma has been significantly enhanced with the addition of Rituximab to the standard chemotherapy regimen. However, even with the advancement of treatment patients continue to relapse and develop resistance to Rituximab, rendering subsequent treatments unsuccessful. The use of novel drugs with unique antitumor mechanisms has gained considerable attention. In this study, we explored the in vitro anti-cancer effects of the combined therapy of Rituximab and Nisin on human Burkitt’s lymphoma cells.Methods:The human Burkitt’s lymphoma cells lines, Raji and Daudi, were treated with Nisin, Rituximab, or a combination of the two agents at various concentrations. Cytotoxicity following treatment was determined using cell viability assay. The degree of apoptosis was verified via flow cytometric analysis using FITC annexin V/PI staining.Results:Our findings show that the combined treatment of Rituximab and Nisin results in a more significant reduction in the survival of Raji and Daudi Burkitt’s lymphoma cells, compared to Nisin or Rituximab treatment alone. Additionally, our results indicate that Nisin can induce a significant degree of apoptosis in the Burkitt’s lymphoma cells compared to the negative controls. However, the addition of Nisin to the Rituximab treatment synergistically enhances the apoptotic antitumor effect.Conclusion:This study demonstrates the synergistic antitumor effect of Nisin treatment in vitro to enhance tumor cell apoptosis and the potential value of Nisin as an adjunct therapy in the treatment of lymphoma.Key Words: Apoptosis, Burkitt’s lymphoma, Cell viability, Combination, Nisin, Rituximab 相似文献
923.
M. Azad Malik M. E. Sabir Ali Frank J. Berry Jaspal Kaur Mina Rowshani Barry C. Smith 《Inorganica chimica acta》1991,180(2)
Aryltellurium(IV) trichlorides react with parent arenes to give diaryltellurium(IV) dichlorides and with cycloalkenes to give aryl(trans-2-chloro-1-cycloalkyl)tellurium(IV) dichlorides or aryl(trans-2-ethoxy-1- cycloalkyl)tellurium(IV) dichlorides in the presence of ethanol. 相似文献