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891.
892.
Lai-Man Chan Carroll Hatier Gordon Parry Zena Werb Mina J. Bissell 《In vitro cellular & developmental biology. Plant》1987,23(4):308-314
Summary Using gelatin, casein, and fibronectin as substrates and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE),
we have identified protein-degrading enzymes in both normal and Rous sarcoma virus-transformed primary avian tendon cells.
Although there are some consistent differences in the profile of the gelatinolytic activities (mainly metalloproteinases)
between normal and transformed cells, the amounts of fibronectin-degrading activities seem to be comparable. In vitro studies
reported here demonstrate that the degradation of fibronectin is partially and specifically inhibited by gelatin and collagen.
We therefore propose that the abundant collagen present in normal tendon cells protects fibronectin against degradation. Conversely,
in transformed cells, where collagen levels are drastically reduced, fibronectin may be more accessible to degradation. Thus
differences in the steady-state levels of fibronectin on normal and transformed cells may be, at least in part, a consequence
of changes in collagen levels.
This work was supported by the Office of Health and Environmental Research, Office of Energy Research, U.S. Department of
Energy, Washington, D.C., under contracts DE-AC03-76-SF00098 and DE-AC03-76-SF01012. 相似文献
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Two synthetic approaches leading toN-4-carboxymethyl-2-nitrobenzyloxycarbonyl derivatives of model compounds and of glycosylsphingosines are described. The carboxymethyl group can be converted into a hydrazido derivative and the resulting products react with an active ester polymer yielding light-sensitive polymeric products that may subsequently serve as acceptors in glycosyltransferase reactions.Author for correspondence. Address until September 1990; Graduate Department of Biochemistry, Brandeis University, 415 South Street, Waltham, MA 02254, USA 相似文献
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Karimi Farzaneh Amiri-Moghaddam Seyedeh Mina Bagheri Zakieh Bahrami Ahmad Reza Goshayeshi Ladan Allahyari Abolghasem Mirsadraee Marjane Fanipakdel Azar Bari Alireza Emadi-Torghabeh Ali Kerachian Mohammad Amin Rahimi Hossein Matin Maryam M. 《Molecular biology reports》2021,48(3):2273-2284
Molecular Biology Reports - Genome-wide association studies have revealed that some single nucleotide polymorphisms at 8q24, such as rs6983267, might be effective in susceptibility to various... 相似文献
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Wen-Ling Lin Mizuki Mizobuchi Mina Kawahigashi Otoki Nakahashi Yuuki Maekawa Takashi Sakai 《Biochemistry and Biophysics Reports》2021
We established a method of KC transplantation by intraperitoneal (i.p.) injection using EGFP-expressing cells (EGFP-KCs) and normal KCs. The novel method is easier and less invasive than conventional methods so that it is not only technically advantageous but also ethically preferable for experiments using animals. We demonstrated that KCs migrated to the liver following i.p. Injection. Engraftment in the liver was not observed for peritoneal macrophages (pMPs). This suggests that KCs migrate to the liver via a sorting mechanism. KC injection decreased the KC number at 24 h and then recovered the KCs at 10 days to a normal level. Additionally, recovery to the normal level by KC injection was observed in mice with KC depletion induced by GdCl3. These results suggest that a regulatory mechanism exists for controlling the number of KCs. 相似文献