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Meriño Miguel Martín Sebastián San Sandaña Pedro Herlitz Kurt Aguayo Claudio Godoy Alejandro Torres-Vergara Pablo Gonzalez Marcelo Troncoso Felipe Acurio Jesenia Escudero Carlos 《Purinergic signalling》2020,16(3):427-437
Purinergic Signalling - We aim to investigate the role of A2A receptor in peritonitis-related sepsis by injection of a fecal solution (FS) as a model of polymicrobial infection. C57/black J6... 相似文献
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The Galician rias are singular and complex estuarine systems of great economic importance. Seagrasses are key elements of
the ecosystem and favor the maintenance of high species diversity in benthic communities. Nevertheless, the ecological role
of seagrass meadows in the Galician rias has been only partially assessed. Peracarid crustaceans are an important component
of soft-bottom faunas and have great importance for the structure of benthic assemblages. In this work, species diversity,
patterns of distribution and seasonal fluctuations of peracarids (Crustacea, Peracarida) are studied in estuarine sediments
colonized by two species of Zostera (Z. marina and Z. noltii) at the O Grove inlet (Ría de Arousa, Galicia, NW Iberian Peninsula). The spatial distribution of peracarid assemblages was
characterized by high numerical dominances due to a few species, particularly tanaidaceans. The temporal study at a Z. marina meadow showed a strongly seasonal pattern defined by great fluctuations of the amphipod population, the latter being the
dominant group in abundance and number of species. The highest numbers of species and individuals were observed in September,
with minimum values in March. Analyses pointed out a high correlation among the granulometric features of the studied bottoms
and the faunistic attributes. Nevertheless, the presence of the seagrasses should influence in a major way the hydrodynamic
and sedimentary features of the habitat and utterly the spatial and temporal patterns observed in the peracarid assemblage
in the O Grove inlet. 相似文献
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Ramonet D Daher JP Lin BM Stafa K Kim J Banerjee R Westerlund M Pletnikova O Glauser L Yang L Liu Y Swing DA Beal MF Troncoso JC McCaffery JM Jenkins NA Copeland NG Galter D Thomas B Lee MK Dawson TM Dawson VL Moore DJ 《PloS one》2011,6(4):e18568
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 mutations represent the most common cause of PD with clinical and neurochemical features that are largely indistinguishable from idiopathic disease. Currently, transgenic mice expressing wild-type or disease-causing mutants of LRRK2 have failed to produce overt neurodegeneration, although abnormalities in nigrostriatal dopaminergic neurotransmission have been observed. Here, we describe the development and characterization of transgenic mice expressing human LRRK2 bearing the familial PD mutations, R1441C and G2019S. Our study demonstrates that expression of G2019S mutant LRRK2 induces the degeneration of nigrostriatal pathway dopaminergic neurons in an age-dependent manner. In addition, we observe autophagic and mitochondrial abnormalities in the brains of aged G2019S LRRK2 mice and markedly reduced neurite complexity of cultured dopaminergic neurons. These new LRRK2 transgenic mice will provide important tools for understanding the mechanism(s) through which familial mutations precipitate neuronal degeneration and PD. 相似文献
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Two new trochids of the genus Antimargarita, A. powelli and A. bentarti, from the Antarctic waters are described here. A. powelli, from the Bellingshausen Sea, is distinguished by its rounded whorls, numerous spiral cords, a radula with seven lateral
teeth at each side of the rachidian, and an epipodium with eight pairs of tentacles. A. bentarti, from the South Shetland Islands, is characterized by having a shell outline gradated by prominent primary spiral cords,
a radula with five lateral teeth at each side of the rachidian and an epipodium with six tentacles on the left side. The diagnostic
features for Antimargarita are redefined considering both shell and anatomical features and its suprageneric placement is discussed. 相似文献
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Troncoso AJ Vargas RR Tapia DH Olivares-Donoso R Niemeyer HM 《Bulletin of entomological research》2005,95(1):23-28
Decision-making during host selection by phytophagous insects has proved to be related to host range, with specialists taking faster decisions than generalists; however, this pattern fails to materialize in some host selection studies performed with aphids. Differences found in testing designs point to rearing effects on aphid host selection. To test whether specialization patterns derive from the nature of the aphid or as a consequence of rearing environment, host selection behaviours were compared between the generalist Myzus persicae (Sulzer) s.s. and its subspecies specialized on tobacco when reared on a common host and offered the choice of an alternative host and a non-host plant. Pre-alighting (host finding and attraction towards host volatiles) and post-alighting (leaf surface exploration and probing) behaviours did not differ between the generalist and the tobacco-specialist, except in the allocation of time to probing behaviour; furthermore, all specialists chose the host on which they performed best. Thus, although the specialist was not faster than the generalist, it showed a higher level of commitment to its preferred host plant. 相似文献