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排序方式: 共有186条查询结果,搜索用时 187 毫秒
181.
182.
Enni Bertling Peter Blaesse Patricia Seja Elena Kremneva Gergana Gateva Mari A Virtanen Milla Summanen Inkeri Spoljaric Pavel Uvarov Michael Blaesse Ville O Paavilainen Laszlo Vutskits Kai Kaila Pirta Hotulainen Eva Ruusuvuori 《EMBO reports》2021,22(4)
Intracellular pH is a potent modulator of neuronal functions. By catalyzing (de)hydration of CO2, intracellular carbonic anhydrase (CAi) isoforms CA2 and CA7 contribute to neuronal pH buffering and dynamics. The presence of two highly active isoforms in neurons suggests that they may serve isozyme‐specific functions unrelated to CO2‐(de)hydration. Here, we show that CA7, unlike CA2, binds to filamentous actin, and its overexpression induces formation of thick actin bundles and membrane protrusions in fibroblasts. In CA7‐overexpressing neurons, CA7 is enriched in dendritic spines, which leads to aberrant spine morphology. We identified amino acids unique to CA7 that are required for direct actin interactions, promoting actin filament bundling and spine targeting. Disruption of CA7 expression in neocortical neurons leads to higher spine density due to increased proportion of small spines. Thus, our work demonstrates highly distinct subcellular expression patterns of CA7 and CA2, and a novel, structural role of CA7. 相似文献
183.
The most vulnerable stage in the life of plants is the seedling. The transition from wild to agricultural land that plants experienced during and after domestication implied a noticeable change in the seedlings′ environment. Building on current knowledge of seedling ecology, and on previous studies of cassava, we hypothesise that cultivation should have promoted epigeal germination of seedlings, and more exposed and photosynthetic cotyledons. To test this hypothesis, we phenotyped seedling morpho‐functional traits in a set of domesticated and wild progenitor accessions of 20 Eudicot herbaceous crop species. Qualitative traits like epi‐ versus hypogeal germination, leafy versus storage type of cotyledons, or crypto‐ versus phanerocotyledonar germination, remained conserved during the domestication of all 20 species. Lengths of hypocotyls and epicotyls, of cotyledon petioles, and indices of cotyledon exposure to the aboveground environment changed during evolution under cultivation. However, those changes occurred in diverse directions, depending on the crop species. No common seedling phenotypic convergence in response to domestication was thus detected among the group of species studied here. Also, none of the 20 crops evolved in accordance with our initial hypothesis. Our results reject the idea that strong selective filters exerted unconsciously by artificial selection should have resulted in generalised channelling of seedling morphology towards more productive and more herbivore risky phenotypes. This result opens up unexplored opportunities for directional breeding of seedling traits. 相似文献
184.
Milla Jokl 《Plant Systematics and Evolution》1918,67(1):33-37
Ohne Zusammenfassung 相似文献
185.
Opiate agonists and enterotoxins 总被引:1,自引:0,他引:1
186.
Sylvain Milla Xavier Terrien Armin Sturm Fidaa Ibrahim Franck Giton Jean Fiet Patrick Prunet Florence Le Gac 《Reproductive biology and endocrinology : RB&E》2008,6(1):19