排序方式: 共有37条查询结果,搜索用时 15 毫秒
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Flow cytometry and capillary electrophoresis analyses in ethanol‐stressed Oenococcus oeni strains and changes assessment of membrane fatty acid composition
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M.G. Bonomo C. Cafaro A. Guerrieri F. Crispo L. Milella L. Calabrone G. Salzano 《Journal of applied microbiology》2017,122(6):1615-1626
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Exploring the relationship between entheseal changes and physical activity: A multivariate study
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Marco Milella Francisca Alves Cardoso Sandra Assis Geneviève Perréard Lopreno Nivien Speith 《American journal of physical anthropology》2015,156(2):215-223
Analyses of entheseal changes (EC) in identified skeletal samples employ a common research strategy based on the comparison between occupations grouped on the basis of shared biomechanical and/or social characteristics. Results from this approach are often ambiguous, with some studies that point to differences in EC between occupational samples and others failing to provide evidence of behavioral effects on EC. Here we investigate patterns of EC among documented occupations by means of a multivariate analysis of robusticity scores in nine postcranial entheses from a large (N = 372) contemporary skeletal sample including specimens from one Italian and two Portuguese identified collections. Data on entheseal robusticity, analyzed by pooled sides as well by separated sides and levels of asymmetry, are converted in binary scores and then analyzed through nonlinear principal component analysis and hierarchical cluster analysis. Results of these analyses are then used for the classification of occupations. Differences between occupational classes are tested by MANOVA and pairwise Hotelling's test. Results evidence three classes which separate occupations related to farming, physically demanding but generalized occupation, and physically undemanding occupations, with the more consistent differences between the first and the last classes. Our results are consistent with differences in biomechanical behavior between the occupations included in each class, and point to the physical and social specificity of farming activities. On the other hand, our study exemplifies the usefulness of alternative analytical protocols for the investigation of EC, and the value of research designs devoid of a priori assumptions for the test of biocultural hypotheses. Am J Phys Anthropol 156:215–223, 2015. © 2014 Wiley Periodicals, Inc. 相似文献
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Francesco Tramutola Maria Francesca Armentano Federico Berti Lucia Chiummiento Paolo Lupattelli Rosarita DOrsi Rocchina Miglionico Luigi Milella Faustino Bisaccia Maria Funicello 《Bioorganic & medicinal chemistry》2019,27(9):1863-1870
New heteroaryl HIV-protease inhibitors bearing a carbamoyl spacer were synthesized in few steps and high yield, from commercially available homochiral epoxides. Different substitution patterns were introduced onto a given isopropanoyl-sulfonamide core that can have either H or benzyl group. The in vitro inhibition activity against recombinant protease showed a general beneficial effect of both carbamoyl moiety and the benzyl group, ranging the IC50 values between 11 and 0.6?nM. In particular, benzofuryl and indolyl derivatives showed IC50 values among the best for such structurally simple inhibitors. Docking analysis allowed to identify the favorable situation of such derivatives in terms of number of interactions in the active site, supporting the experimental results.The inhibition activity was also confirmed in HEK293 mammalian cells and was maintained against protease mutants. Furthermore, the metabolic stability was comparable with that of the commercially available inhibitors. 相似文献
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