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992.
Jan?Christian?HabelEmail author Mike?Teucher Ronald?K.?Mulwa Wolfgang?Haber Hilde?Eggermont Luc?Lens 《Biodiversity and Conservation》2016,25(4):791-799
Currently, there is an increasing need for evidence-based strategies in nature conservation, for example when designing and establishing nature reserves. In this contribution, we critically assess the ecological relevance of recent nature conservation practices in Kenya (East Africa), a region of global biodiversity hotspots. More specifically, we overlay the distribution of species richness (here based on mammals, birds, amphibians and vascular plants) with the location of nature reserves, the Kenyan agro-ecological zones (areas representing diverging agricultural potentials), and with the spatial distribution of human population density. Our analyses indicate that the majority of protected areas are located in areas with comparatively low species richness, while areas with extraordinary high levels of species richness are not adequately covered by nature reserves. Areas of high agricultural productivity (and with high human demographic pressure) are mainly reserved for high-yield agriculture; however, these regions are also characterised by high species richness. The majority of nature reserves are restricted to the semi-arid regions of Kenya, marginal for agricultural usage, but also with low levels of species richness. Based on this analysis, we prioritize areas for future protection. This single-country case illustrates that agricultural production in high-yield areas outweighs nature conservation goals, even in global biodiversity hotspot regions, and that priority setting may conflict with effective nature conservation. 相似文献
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Terpene metabolic engineering via nuclear or chloroplast genomes profoundly and globally impacts off‐target pathways through metabolite signalling
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995.
William C. H. Parr Laura A. B. Wilson Stephen Wroe Nicholas J. Colman Mathew S. Crowther Mike Letnic 《Evolutionary biology》2016,43(2):171-187
Australia’s native wild dog, the dingo (Canis dingo), is threatened by hybridization with feral or domestic dogs. In this study we provide the first comprehensive three dimensional geometric morphometric evaluation of cranial shape for dingoes, dogs and their hybrids. We introduce a novel framework to assess whether modularity facilitates, or constrains, cranial shape change in hybridization. Our results show that hybrid and pure dingo morphology overlaps greatly, meaning that hybrids cannot be reliably distinguished from dingoes on the basis of cranial metrics. We find that dingo morphology is resistant, with observed hybrids exhibiting morphology closer to the dingo than to the parent group dog. We also find that that hybridization with dog breeds does not push the dingo cranial morphology towards the wolf phenotype. Disparity and integration analyses on the ten recovered modules provided empirical support for modularity facilitating shape change over short evolutionary time scales. However, our results show that this is may not be the case in hybridization events, which were not influenced by module integration or disparity levels. We conclude that although hybridization events may introduce breed dog DNA to the dingo population, the native cranial morphology, and therefore likely the feeding eco-niche, of the dingo population is resistant to change. Our results have implications for conservation and management of dingoes and, more broadly, for the influence of integration patterns over ecological time scales in relation to selection pressure. 相似文献
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Shahram Ghanaati Adorján Kovács Mike Barbeck Jonas Lorenz Anna Teiler Nader Sadeghi Charles James Kirkpatrick Robert Sader 《Journal of cell communication and signaling》2016,10(1):3-15
Classically skin defects are covered by split thickness skin grafts or by means of local or regional skin flaps. In the presented case series for the first time a bilayered, non-crossed-linked collagen matrix has been used in an off-label fashion in order to reconstruct facial skin defects following different types of skin cancer resection. The material is of porcine origin and consists of a spongy and a compact layer. The ratio of the two layers is 1:3 in favour of the spongy layer. The aim of the study was to investigate the potential of this matrix for skin regeneration as an alternative to the standard techniques of skin grafts or flaps. Six patients between 39 and 83 years old were included in the study based on a therapeutic trial. The collagen matrix was used in seven defects involving the nose, eyelid, forehead- and posterior scalp regions, and ranging from 1,2 to 6 cm in diameter. Two different head and neck surgeons at two different institutions performed the operations. Each used a different technique in covering the wound following surgery, i.e. with and without a latex-based sheet under the pressure dressing. In three cases cylindrical biopsies were taken after 14 days. In all cases the biomaterial application was performed without any complication and no adverse effects were observed. Clinically, the collagen matrix contributed to a tension-free skin regeneration, independent of the wound dressing used. The newly regenerated skin showed strong similarity to the adjacent normal tissue both in quality and colour. Histological analysis indicated that the spongy layer replaced the defective connective tissue, by providing stepwise integration into the surrounding implantation bed, while the compact layer was infiltrated by mononuclear cells and contributed to its epithelialization by means of a ?conductive“process from the surrounding epithelial cells. The clinical and histological data demonstrate that the collagen bilayered matrix used in this series contributes to a ?Guided-Integrative-Regeneration-Process“, which still needs to be further understood. The biomimetic nature of this material seems to contribute to physiological matrix remodelling, which probably involves other matricellular proteins essential for soft tissue regeneration. A deeper understanding of the mechanism, involved in the tissue integration of this material and its contribution to soft tissue regeneration based on the direct and indirect effect of matricellular proteins could open new therapeutic avenues for biomaterial-based soft tissue regeneration as an alternative to traditional flap-based plastic surgery. 相似文献
999.
Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: The Food4Me study
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Carlos Celis‐Morales Cyril F.M. Marsaux Katherine M. Livingstone Santiago Navas‐Carretero Rodrigo San‐Cristobal Clare B. O'donovan Hannah Forster Clara Woolhead Rosalind Fallaize Anna L. Macready Silvia Kolossa Jacqueline Hallmann Lydia Tsirigoti Christina P. Lambrinou George Moschonis Magdalena Godlewska Agnieszka Surwio Keith Grimaldi Jildau Bouwman Yannis Manios Iwona Traczyk Christian A. Drevon Laurence D. Parnell Hannelore Daniel Eileen R. Gibney Lorraine Brennan Marianne C. Walsh Mike Gibney Julie A. Lovegrove J. Alfredo Martinez Wim H.M. Saris John C. Mathers 《Obesity (Silver Spring, Md.)》2016,24(4):962-969
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