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Cu-thioneins isolated from liver and brains are able to transfer their copper atoms to apoforms of neurocuprein 1 and 2. At the same time, the apoform of Cu-thionein is unable to accept copper from holoforms of both neurocupreins. 相似文献
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The copper-containing protein, neurocuprein, has been obtained in a highly purified state from human brain. Many similarities in properties of neurocupreins from human and bovine brains are noted. These concern molecular weights, copper contents, isoelectric points, amino acid compositions, optical and EPR spectra as well as their reaction with catecholamines. However, it was found that the content of neurocuprein in the whole human brain is significantly (by a factor 2.5–3.0) higher than in bovine brain. 相似文献
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Irina N. Dolganova Arsen K. Zotov Larisa P. Safonova Polina V. Aleksandrova Igor V. Reshetov Kirill I. Zaytsev Valery V. Tuchin Vladimir N. Kurlov 《Journal of biophotonics》2023,16(3):e202200288
This article describes a sapphire cryoprobe as a promising solution to the significant problem of modern cryosurgery that is the monitoring of tissue freezing. This probe consists of a sapphire rod manufactured by the edge-defined film-fed growth technique from Al2O3 melt and optical fibers accommodated inside the rod and connected to the source and the detector. The probe's design enables detection of spatially resolved diffuse reflected intensities of tissue optical response, which are used for the estimation of tissue freezing depth. The current type of the 12.5-mm diameter sapphire probe cooled down by the liquid nitrogen assumes a superficial cryoablation. The experimental test made by using a gelatin-intralipid tissue phantom shows the feasibility of such concept, revealing the capabilities of monitoring the freezing depth up to 10 mm by the particular instrumentation realization of the probe. This justifies a potential of sapphire-based instruments aided by optical diagnosis in modern cryosurgery. 相似文献
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Nataliya R. Rovnyagina Gleb S. Budylin Pavel V. Dyakonov Yuri M. Efremov Marina M. Lipina Yuliya R. Goncharuk Emirkhan E. Murdalov David A. Pogosyan Denis A. Davydov Alexander A. Korneev Natalia B. Serejnikova Karen A. Mikaelyan Stanislav A. Evlashin Vladimir A. Lazarev Alexey V. Lychagin Peter S. Timashev Evgeny A. Shirshin 《Journal of biophotonics》2023,16(3):e202200149
Osteoarthritis (OA) is one of the most common joint diseases worldwide. Unfortunately, clinical methods lack the ability to detect OA in the early stages. Timely detection of the knee joint degradation at the level of tissue changes can prevent its progressive damage. Here, diffuse reflectance spectroscopy (DRS) in the NIR range was used to obtain optical markers of the cartilage damage grades and to assess its mechanical properties. It was observed that the water content obtained by DRS strongly correlates with the cartilage thickness (R = .82) and viscoelastic relaxation time (R = .7). Moreover, the spectral parameters, including water content (OH-band), protein content (CH-band), and scattering parameters allowed for discrimination between the cartilage damage grades (10−4 < P ≤ 10−3). The developed approach may become a valuable addition to arthroscopy, helping to identify lesions at the microscopic level in the early stages of OA and complement the surgical analysis. 相似文献