全文获取类型
收费全文 | 474篇 |
免费 | 39篇 |
出版年
2023年 | 1篇 |
2022年 | 13篇 |
2021年 | 17篇 |
2020年 | 10篇 |
2019年 | 11篇 |
2018年 | 10篇 |
2017年 | 16篇 |
2016年 | 11篇 |
2015年 | 22篇 |
2014年 | 34篇 |
2013年 | 35篇 |
2012年 | 47篇 |
2011年 | 41篇 |
2010年 | 21篇 |
2009年 | 23篇 |
2008年 | 23篇 |
2007年 | 33篇 |
2006年 | 22篇 |
2005年 | 26篇 |
2004年 | 18篇 |
2003年 | 14篇 |
2002年 | 13篇 |
2001年 | 9篇 |
2000年 | 9篇 |
1999年 | 6篇 |
1998年 | 1篇 |
1997年 | 3篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1991年 | 1篇 |
1989年 | 2篇 |
1987年 | 1篇 |
1986年 | 2篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1981年 | 2篇 |
1980年 | 3篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1973年 | 1篇 |
1972年 | 1篇 |
排序方式: 共有513条查询结果,搜索用时 15 毫秒
501.
Mina Tabak Keren Scher Michael L. Chikindas & Sima Yaron 《FEMS microbiology letters》2009,301(1):69-76
Triclosan is a biocide whose wide use has raised a debate about the potential benefits vs. hazards of the incorporation of antimicrobials in consumer products. The purpose of the present study was to determine whether exposure of biofilms of Salmonella enterica serovar Typhimurium to triclosan influences the tolerance of the bacteria towards antibiotics such as ciprofloxacin and vice versa. A synergistic antibiofilm activity was observed when the biofilms were treated with triclosan before or together with ciprofloxacin, and an additive activity was observed with planktonic cells. For example 500 μg mL−1 triclosan and 500 μg mL−1 ciprofloxacin reduced the number of viable cells in the biofilm by 1.6 and 0.5 log, respectively. However, the sequential treatment of 500 μg mL−1 triclosan followed by ciprofloxacin resulted in 4.8 log reduction. Combination indexes (CI) for biofilms treated with triclosan followed by ciprofloxacin were 0.7, 0.32 and 0.25 for reduction of 90%, 99% and 99.9%, respectively, indicating a synergism. For planktonic cells, CIs were 1±0.1, indicating an additive effect. Therefore, it was suggested that triclosan weakens the ability of biofilm-associated cells to survive exposure to ciprofloxacin in the biofilm, probably by improving the permeability or the activity of ciprofloxacin. 相似文献
502.
503.
504.
Ayelet R. Amsalem Barak Marom Keren E. Shapira Tal Hirschhorn Livia Preisler Pia Paarmann Petra Knaus Yoav I. Henis Marcelo Ehrlich 《Molecular biology of the cell》2016,27(4):716-730
The expression and function of transforming growth factor-β superfamily receptors are regulated by multiple molecular mechanisms. The type II BMP receptor (BMPRII) is expressed as two alternatively spliced forms, a long and a short form (BMPRII-LF and –SF, respectively), which differ by an ∼500 amino acid C-terminal extension, unique among TGF-β superfamily receptors. Whereas this extension was proposed to modulate BMPRII signaling output, its contribution to the regulation of receptor expression was not addressed. To map regulatory determinants of BMPRII expression, we compared synthesis, degradation, distribution, and endocytic trafficking of BMPRII isoforms and mutants. We identified translational regulation of BMPRII expression and the contribution of a 3’ terminal coding sequence to this process. BMPRII-LF and -SF differed also in their steady-state levels, kinetics of degradation, intracellular distribution, and internalization rates. A single dileucine signal in the C-terminal extension of BMPRII-LF accounted for its faster clathrin-mediated endocytosis relative to BMPRII-SF, accompanied by mildly faster degradation. Higher expression of BMPRII-SF at the plasma membrane resulted in enhanced activation of Smad signaling, stressing the potential importance of the multilayered regulation of BMPRII expression at the plasma membrane. 相似文献
505.
Won Dong Lee Anna Chiara Pirona Boris Sarvin Alon Stern Keren Nevo-Dinur Elazar Besser Nikita Sarvin Shoval Lagziel Dzmitry Mukha Shachar Raz Elina Aizenshtein Tomer Shlomi 《Cell metabolism》2021,33(1):190-198.e6
- Download : Download high-res image (130KB)
- Download : Download full-size image
506.
Keren Agay‐Shay Michael Friger Shai Linn Ammatzia Peled Yona Amitai Chava Peretz 《Birth defects research. Part A, Clinical and molecular teratology》2012,94(6):438-448
BACKGROUND Congenital malformations (CMs) are a leading cause of infant disability. Geophysical patterns such as 2‐year, yearly, half‐year, 3‐month, and lunar cycles regulate much of the temporal biology of all life on Earth and may affect birth and birth outcomes in humans. Therefore, the aim of this study was to evaluate and compare trends and periodicity in total births and CM conceptions in two Israeli populations. METHODS Poisson nonlinear models (polynomial) were applied to study and compare trends and geophysical periodicity cycles of weekly births and weekly prevalence rate of CM (CMPR), in a time‐series design of conception date within and between Jews and Muslims. The population included all live births and stillbirths (n = 823,966) and CM (three anatomic systems, eight CM groups [n = 2193]) in Israel during 2000 to 2006. Data were obtained from the Ministry of Health. RESULTS We describe the trend and periodicity cycles for total birth conceptions. Of eight groups of CM, periodicity cycles were statistically significant in four CM groups for either Jews or Muslims. Lunar month and biennial periodicity cycles not previously investigated in the literature were found to be statistically significant. Biennial cycle was significant in total births (Jews and Muslims) and syndactyly (Muslims), whereas lunar month cycle was significant in total births (Muslims) and atresia of small intestine (Jews). CONCLUSION We encourage others to use the method we describe as an important tool to investigate the effects of different geophysical cycles on human health and pregnancy outcomes, especially CM, and to compare between populations. Birth Defects Research (Part A) 2012. © 2012 Wiley Periodicals, Inc. 相似文献
507.
508.
509.
Bie Jia Zheng Keren Gao Xiang Liu Boyang Ma Jun Hayat Muhammad Abid Xiao Jianhua Wang Hongbin 《EcoHealth》2021,18(1):3-12
EcoHealth - Chytridiomycosis, a leading cause for the global decline in the number of amphibians, is caused by the fungal pathogen Batrachochytrium dendrobatidis. In this study, global distribution... 相似文献
510.
Cuige Zhu Sun-Joong Kim Arshag Mooradian Faliang Wang Ziqian Li Sean Holohan Patrick L. Collins Keren Wang Zhanfang Guo Jeremy Hoog Cynthia X. Ma Eugene M. Oltz Jason M. Held Jieya Shao 《Cell reports》2021,34(7):108749
- Download : Download high-res image (192KB)
- Download : Download full-size image