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Meysam Hashemi Anirudh N. Vattikonda Viktor Sip Sandra Diaz-Pier Alexander Peyser Huifang Wang Maxime Guye Fabrice Bartolomei Marmaduke M. Woodman Viktor K. Jirsa 《PLoS computational biology》2021,17(7)
Individualized anatomical information has been used as prior knowledge in Bayesian inference paradigms of whole-brain network models. However, the actual sensitivity to such personalized information in priors is still unknown. In this study, we introduce the use of fully Bayesian information criteria and leave-one-out cross-validation technique on the subject-specific information to assess different epileptogenicity hypotheses regarding the location of pathological brain areas based on a priori knowledge from dynamical system properties. The Bayesian Virtual Epileptic Patient (BVEP) model, which relies on the fusion of structural data of individuals, a generative model of epileptiform discharges, and a self-tuning Monte Carlo sampling algorithm, is used to infer the spatial map of epileptogenicity across different brain areas. Our results indicate that measuring the out-of-sample prediction accuracy of the BVEP model with informative priors enables reliable and efficient evaluation of potential hypotheses regarding the degree of epileptogenicity across different brain regions. In contrast, while using uninformative priors, the information criteria are unable to provide strong evidence about the epileptogenicity of brain areas. We also show that the fully Bayesian criteria correctly assess different hypotheses about both structural and functional components of whole-brain models that differ across individuals. The fully Bayesian information-theory based approach used in this study suggests a patient-specific strategy for epileptogenicity hypothesis testing in generative brain network models of epilepsy to improve surgical outcomes. 相似文献
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Derakhshan Samira Aminishakib Pouyan Pirzadeh Fatemeh Rahrotaban Sedigheh Farzaneh Parvaneh Tavakoli Shiraji Sahar Ganjibakhsh Meysam Asadi Masoumeh 《Molecular biology reports》2021,48(4):3223-3235
Molecular Biology Reports - Aflibercept and arsenic trioxide drugs apply a cytotoxic effect on some human cancer cell lines. However, no more study has followed the effects of both drugs,... 相似文献
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A Gram staining technique was developed using monodisperse magnetic beads in concentrating bacteria in suspension for downstream application. The technique does not require heat fixation of organisms, electrical power, or a microscope. Gram-negative and Gram-positive bacteria were identified macroscopically based on the colour of the suspension. The bacteria concentrated on magnetic beads may also be identified microscopically. 相似文献
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Shiva Mohamadi Moghanjoghi Meysam Ganjibakhsh Neda Sadat Gohari Mehrnaz Izadpanah Hedieh Rahmati Zahra Elyasi Gorji Nazanin Mohebali Faezeh Vakhshiteh Parvaneh Farzaneh 《Cytotechnology》2018,70(5):1337-1347
Some of lizard species have the ability to lose their tail in order to defend against predators and regenerate the new tail. Lizard’s regenerated tail has attracted scientists’ attention for unraveling the regeneration process, but less information is known about the cellular characterization and cell growth properties of original tail. This research aimed to report cell culture and banking process of rough-tailed gecko or Cyrtopodion scabrum’s original tail cell sample from inner tissue without skin using tissue explant technique. For banking reports, it is essential to analyze this cells’ potential to proliferate, to investigate biological aspects such as cell culture features, differentiation and chromosome number and to report its species identification and quality control. To achieve optimal growth conditions, three different temperatures for incubation including 18, 23 and 37 °C and two different media including DMEM and L-15 were applied. The expanded cells were studied for their potential to adipose and osteoblast differentiation. Results indicated that lizard’s original tail cells could be successfully obtained by explant technique. The cells demonstrated fibroblast like morphology with population doubling times of approximately 24?±?0.5 h. Karyotyping analysis showed a distribution of 2n?=?40 chromosome number for this cell line. The comparison of different incubation media and temperatures showed that cell growth is equally optimal in all mentioned conditions according to growth curves. Adipose and osteoblast differentiation was obviously observed in these cells which confirms the hint of stem-ness in the produced mixed cells. According to cell banking policies, produced cells were also checked for bacterial, fungal, yeast and mycoplasma contaminations and no contamination was observed. Multiplex PCR for identification of species confirmed the species of lizard with no cross-contamination with other cells in the cell bank. Establishment of authenticated and well-characterized lizard’s original tail cell line will provide a valuable source for subsequent in vitro regenerative research and molecular studies which are not feasible in in vivo methods. This finding will allow us to get an opportunity to create and preserve a new collection of lizard cell lines in the future. 相似文献
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Razieh?RazaviEmail author Seyyed?Milad?Abrishamifar Gholamreza?Ebrahimzadeh?Rajaei Mohammad?Reza?Rezaei?Kahkha Meysam?NajafiEmail author 《Journal of molecular modeling》2018,24(3):64
The applicability of C44, B22N22, Ge44, and Al22P22 nanocages, as well as variants of those nanocages with an adsorbed halogen atom, as high-performance anode materials in Li-ion, Na-ion, and K-ion batteries was investigated theoretically via density functional theory. The results obtained indicate that, among the nanocages with no adsorbed halogen atom, Al22P22 would be the best candidate for a novel anode material for use in metal-ion batteries. Calculations also suggest that K-ion batteries which utilize these nanocages as anode materials would give better performance and would yield higher cell voltages than the corresponding Li-ion and Na-ion batteries with nanocage-based anodes. Also, the results for the nanocages with an adsorbed halogen atom imply that employing them as anode materials would lead to higher cell voltages and better metal-ion battery performance than if the nanocages with no adsorbed halogen atom were to be used as anode materials instead. Results further implied that nanocages with an adsorbed F atom would give higher cell voltages and better battery performance than nanocages with an adsorbed Cl or Br atom. We were ultimately able to conclude that a K-ion battery that utilized Al21P22 with an adsorbed F atom as its anode material would afford the best metal-ion battery performance; we therefore propose this as a novel highly efficient metal-ion battery. 相似文献
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Sarshar Meysam Scribano Daniela Limongi Dolores Zagaglia Carlo Palamara Anna Teresa Ambrosi Cecilia 《International microbiology》2022,25(3):481-494
International Microbiology - Urinary tract infections (UTIs) are a major concern in public health. The prevalent uropathogenic bacterium in healthcare settings is Escherichia coli. The increasing... 相似文献
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Heidari Barchi Nezhad Rahim Asadi Fateme Abtahi Froushani Seyyed Meysam Hassanshahi Gholamhossein Kaeidi Ayat Khanamani Falahati-pour Soudeh Hashemi Zahra Mirzaei Mohammad Reza 《Molecular biology reports》2019,46(6):6135-6146
Molecular Biology Reports - The present study was conducted aimed at exploring the modulatory effects of 17-b estradiol (17-bED) on mesenchymal stem cells (MSCs) in the EAE (experimental autoimmune... 相似文献