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111.
Pyrimidine excretion by cultured fibroblasts: effect of mutational deficiency in pyrimidine salvage enzymes 总被引:3,自引:0,他引:3
In cultured fibroblasts, a mutation resulting in deficiency of a pyrimidine salvage enzyme leads to excretion of related pyrimidines. For example, absence of thymidine kinase led to loss of thymidine and deoxyuridine, and absence of deoxycytidine kinase to loss of deoxyuridine. Both wild type and mutant cells excreted uracil; if established lines are representative in this respect, a fully adequate salvage system for uracil does not seem to be present in the fibroblast. 相似文献
112.
Alterations leading to increased ribonucleotide reductase in cells selected for resistance to deoxynucleosides 总被引:6,自引:0,他引:6
Sublines with altered ribonucleotide reductase have been isolated from the mouse fibroblast line 3T6 by selection for resistance to arabinosyl cytosine and the deoxynucleosides of adenine, thymidine, and guanine. The alterations in enzyme activity are of two kinds: (a) 4–10 fold higher levels of enzyme activity per unit of cell protein; (b) partial desensitization of the enzyme to the allosteric negative effector dATP. The combination of these two alterations keeps the reductase activity of extracts of these deoxynucleoside-resistant clones at wild type levels even in the presence of high concentrations of the deoxynucleotides. The alterations of reductase activity are stable over long periods of cultivation in the absence of deoxynucleosides, and are presumably due to mutation. Despite these changes, the reductase activity is still regulated during growth, since it is much lower in resting than in growing cells. 相似文献
113.
A novel pathway for transversion mutation induced by dCTP misincorporation in a mutator strain of CHO cells. 总被引:2,自引:1,他引:1
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Intracellular imbalances of dCTP produce both T----C transitions and an unusual class of transversions (A----C) at the aprt locus of CHO cells. Our data suggest that this transversion pathway is the consequence of dCTP:T mispairs which are not efficiently proofread during DNA replication. 相似文献