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61.
Infection by the parapoxvirus orf virus causes proliferative skin lesions in which extensive capillary proliferation and dilation are prominent histological features. This infective phenotype may be linked to a unique virus-encoded factor, a distinctive new member of the vascular endothelial growth factor (VEGF) family of molecules. We constructed a recombinant orf virus in which the VEGF-like gene was disrupted and show that inactivation of this gene resulted in the loss of three VEGF activities expressed by the parent virus: mitogenesis of vascular endothelial cells, induction of vascular permeability, and activation of VEGF receptor 2. We used the recombinant orf virus to assess the contribution of the viral VEGF to the vascular response seen during orf virus infection of skin. Our results demonstrate that the viral VEGF, while recognizing a unique profile of the known VEGF receptors (receptor 2 and neuropilin 1), is able to stimulate a striking proliferation of blood vessels in the dermis underlying the site of infection. Furthermore, the data demonstrate that the viral VEGF participates in promoting a distinctive pattern of epidermal proliferation. Loss of a functional viral VEGF resulted in lesions with markedly reduced clinical indications of infection. However, viral replication in the early stages of infection was not impaired, and only at later times did it appear that replication of the recombinant virus might be reduced. 相似文献
62.
John Ambler Emma Baker Lyndon Brown Paul Butler Dave Farr Karen Dunnet Darren Le Grand Diana Janus Darryl Jones Keith Menear Mark Mercer Garrick Smith Mark Talbot Morris Tweed 《Bioorganic & medicinal chemistry letters》1998,8(24):189-3588
The chemical optimisation of CGH1668 1 is described employing an in vivo model of absorption to determine the influence on bioavailability of single point modifications to five key molecular templates. The discovery of an orally bioavailable and selective thrombin inhibitor, 24, highlights the utility of this approach. 相似文献
63.
Ø. Tøien J. B. Mercer 《Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology》1998,168(2):73-80
Hypothalamic temperature (T
hypo) and metabolic heat production (M) were measured in seven conscious rabbits injected intravenously with either saline or
with Staphylococcus aureus, (8 · 107 cell walls · kg−1) while being subjected to a 3-h period of ramp-like total body cooling using a chronically implanted intravascular heat exchanger.
In pyrogen-injected animals cooling started (1) at the time of injection or (2) 70 min after injection. In (1) the fall in
T
hypo induced by heat extraction was similar (1.0 °C) in afebrile and febrile animals. In (2) there was a transient increase in
T
hypo of about 0.5 °C at a time corresponding to the start of fever resulting in a significantly smaller fall in T
hypo at the end of the 3-h cooling period (0.5 °C vs 0.9 °C, P < 0.05, n = 5). At this time in both (1) and (2) M was lower than theoretically expected from the increase in shivering threshold during
fever. However, most of this effect can be explained when available data showing a decrease in thermosensitivity during S. aureus-induced fever are taken into account. After cessation of cooling in both groups of febrile animals T
hypo rose to about 1 °C higher than the precooling level, which is comparable to the fever level in a separate series of experiments
with S. aureus injection without cooling (1.2 °C).
Accepted: 23 September 1997 相似文献
64.
65.
Active sensing involves the fusion of internally generated motor events with external sensation. For rodents, active somatosensation includes scanning the immediate environment with the mystacial vibrissae. In doing so, the vibrissae may touch an object at any angle in the whisk cycle. The representation of touch and vibrissa self-motion may in principle be encoded along separate pathways, or share a single pathway, from the periphery to cortex. Past studies established that the spike rates in neurons along the lemniscal pathway from receptors to cortex, which includes the principal trigeminal and ventral-posterior-medial thalamic nuclei, are substantially modulated by touch. In contrast, spike rates along the paralemniscal pathway, which includes the rostral spinal trigeminal interpolaris, posteromedial thalamic, and ventral zona incerta nuclei, are only weakly modulated by touch. Here we find that neurons along the lemniscal pathway robustly encode rhythmic whisking on a cycle-by-cycle basis, while encoding along the paralemniscal pathway is relatively poor. Thus, the representations of both touch and self-motion share one pathway. In fact, some individual neurons carry both signals, so that upstream neurons with a supralinear gain function could, in principle, demodulate these signals to recover the known decoding of touch as a function of vibrissa position in the whisk cycle. 相似文献
66.
67.
Partially Redundant Enhancers Cooperatively Maintain Mammalian Pomc Expression Above a Critical Functional Threshold 总被引:1,自引:0,他引:1
68.
69.
Vertical stratification of treeholes used by mosquitoes may reflect resource quality or result from interspecific competition. Mosquitoes able to monopolize treeholes with optimal resources may be over‐represented in the community. Aedes sierrensis, which is well adapted for the Mediterranean climate of California, has evolved in the absence of interspecific competition, so oviposition should reflect resource quality to a large extent. Artificial oviposition traps mounted at four canopy heights facing north or south on trees in a mixed‐oak forest at four elevations of the Pacific Coastal Range were used to assess vertical ovipositional preferences by the western treehole mosquito. Natural dispersal of the ciliated protozoan parasite Lambornella clarki was similarly monitored. Gravid Ae. sierrensis showed no vertical stratification during egg laying in traps. Lambornella clarki were naturally dispersed at relatively low frequency into traps and persisted unless eliminated by larval predation. Aedes sierrensis is not currently constrained into occupying a subset of treeholes. However, invasion of its native range by competitive species may alter oviposition patterns. 相似文献
70.
Spatial segregation of the sexes (SSS) occurs in many dioecious angiosperms, but little data are available on the fitness
advantages, if any, for males and females. We examined whether reciprocally transplanted male and female seedlings of Distichlis spicata, a dioecious grass species that exhibits extreme SSS, differed in their responses to microhabitats and competition treatments.
Plants grown without conspecific competitors grew equally well in both male- or female-majority habitats, suggesting that
male and female plants do not have differential resource needs at the juvenile life-history stage. However, plants subject
to intra-sexual competition were significantly larger than plants subject to inter-sexual competition, suggesting that niche
partitioning may occur in D. spicata. 相似文献