全文获取类型
收费全文 | 237篇 |
免费 | 28篇 |
出版年
2023年 | 1篇 |
2022年 | 2篇 |
2021年 | 6篇 |
2020年 | 6篇 |
2019年 | 1篇 |
2018年 | 4篇 |
2017年 | 3篇 |
2016年 | 4篇 |
2015年 | 7篇 |
2014年 | 9篇 |
2013年 | 13篇 |
2012年 | 27篇 |
2011年 | 16篇 |
2010年 | 19篇 |
2009年 | 16篇 |
2008年 | 14篇 |
2007年 | 13篇 |
2006年 | 3篇 |
2005年 | 11篇 |
2004年 | 16篇 |
2003年 | 9篇 |
2002年 | 11篇 |
2001年 | 5篇 |
2000年 | 4篇 |
1999年 | 3篇 |
1997年 | 2篇 |
1996年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 5篇 |
1991年 | 3篇 |
1990年 | 3篇 |
1988年 | 3篇 |
1987年 | 3篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1983年 | 3篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1973年 | 3篇 |
1972年 | 1篇 |
1970年 | 1篇 |
1967年 | 3篇 |
1966年 | 1篇 |
1965年 | 1篇 |
排序方式: 共有265条查询结果,搜索用时 159 毫秒
51.
52.
Fli-1, an Ets-related transcription factor, regulates erythropoietin-induced erythroid proliferation and differentiation: evidence for direct transcriptional repression of the Rb gene during differentiation.
下载免费PDF全文
![点击此处可从《Molecular and cellular biology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
53.
Facilitated variation: how evolution learns from past environments to generalize to new environments
下载免费PDF全文
![点击此处可从《PLoS computational biology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
One of the striking features of evolution is the appearance of novel structures in organisms. Recently, Kirschner and Gerhart have integrated discoveries in evolution, genetics, and developmental biology to form a theory of facilitated variation (FV). The key observation is that organisms are designed such that random genetic changes are channeled in phenotypic directions that are potentially useful. An open question is how FV spontaneously emerges during evolution. Here, we address this by means of computer simulations of two well-studied model systems, logic circuits and RNA secondary structure. We find that evolution of FV is enhanced in environments that change from time to time in a systematic way: the varying environments are made of the same set of subgoals but in different combinations. We find that organisms that evolve under such varying goals not only remember their history but also generalize to future environments, exhibiting high adaptability to novel goals. Rapid adaptation is seen to goals composed of the same subgoals in novel combinations, and to goals where one of the subgoals was never seen in the history of the organism. The mechanisms for such enhanced generation of novelty (generalization) are analyzed, as is the way that organisms store information in their genomes about their past environments. Elements of facilitated variation theory, such as weak regulatory linkage, modularity, and reduced pleiotropy of mutations, evolve spontaneously under these conditions. Thus, environments that change in a systematic, modular fashion seem to promote facilitated variation and allow evolution to generalize to novel conditions. 相似文献
54.
Yurlova L Kahya N Aggarwal S Kaiser HJ Chiantia S Bakhti M Pewzner-Jung Y Ben-David O Futerman AH Brügger B Simons M 《Biophysical journal》2011,101(11):2713-2720
Rapid conduction of nerve impulses requires coating of axons by myelin sheaths, which are multilamellar, lipid-rich membranes produced by oligodendrocytes in the central nervous system. To act as an insulator, myelin has to form a stable and firm membrane structure. In this study, we have analyzed the biophysical properties of myelin membranes prepared from wild-type mice and from mouse mutants that are unable to form stable myelin. Using C-Laurdan and fluorescence correlation spectroscopy, we find that lipids are tightly organized and highly ordered in myelin isolated from wild-type mice, but not from shiverer and ceramide synthase 2 null mice. Furthermore, only myelin lipids from wild-type mice laterally segregate into physically distinct lipid phases in giant unilamellar vesicles in a process that requires very long chain glycosphingolipids. Taken together, our findings suggest that oligodendrocytes exploit the potential of lipids to self-segregate to generate a highly ordered membrane for electrical insulation of axons. 相似文献
55.
56.
57.
Facilitation in plant communities: the past, the present, and the future 总被引:24,自引:11,他引:24
Rob W. Brooker Fernando T. Maestre Ragan M. Callaway Christopher L. Lortie Lohengrin A. Cavieres Georges Kunstler Pierre Liancourt Katja Tielbörger Justin M. J. Travis Fabien Anthelme Cristina Armas Lluis Coll Emmanuel Corcket Sylvain Delzon Estelle Forey Zaal Kikvidze Johan Olofsson Francisco Pugnaire Constanza L. Quiroz Patrick Saccone Katja Schiffers Merav Seifan Blaize Touzard Richard Michalet 《Journal of Ecology》2008,96(1):18-34
58.
Annual and seasonal changes in diets of martens: evidence from stable isotope analysis 总被引:18,自引:0,他引:18
Theory predicts that generalist predators will switch to alternative prey when preferred foods are not readily available.
Studies on the feeding ecology of the American marten (Martes americana) throughout North America suggest that this mustelid is a generalist predator feeding largely on voles (Microtus sp.; Clethrionomys sp.). We investigated seasonal and annual changes in diets of martens in response to the changing abundance of small rodents
(Peromyscus keeni, and Microtus longicaudus) on Chichagof Island, Southeast Alaska, using stable isotope analysis. We hypothesized that martens would feed primarily
on small rodents during years with high abundance of these prey species, whereas during years of low abundance of prey, martens
would switch to feed primarily on the seasonally available carcasses of salmon. We also hypothesized that home-range location
on the landscape (i.e., access to salmon streams) would determine the type of food consumed by martens, and martens feeding
on preferred prey would exhibit better body condition than those feeding on other foods. We live-captured 75 martens repeatedly,
from mid-February to mid-December 1992–1994. We also obtained marten carcasses from trappers during late autumn 1991 and 1992,
from which we randomly sub-sampled 165 individuals. Using stable isotope ratios and a multiple-source mixing model, we inferred
that salmon carcasses composed a large portion of the diet of martens in autumn during years of low abundance of rodents (1991
and 1992). When small rodents were available in high numbers (1993 and 1994), they composed the bulk of the diet of martens
in autumn, despite salmon carcasses being equally available in all years. Selection for small rodents occurred only in seasons
in which abundance of small rodents was low. Logistic regression revealed that individuals with access to salmon streams were
more likely to incorporate salmon carcasses in their diet during years of low abundance of small rodents. Using stable isotope
analysis on repeated samples from the same individuals, we explored some of the factors underlying feeding habits of individuals
under variable ecological conditions. We were unable to demonstrate that body weights of live-captured male and female martens
differed significantly between individuals feeding on marine-derived or terrestrial diets. Therefore, martens, as true generalist
predators, switched to alternative prey when their principal food was not readily available on a seasonal or annual basis.
Although salmon carcasses were not a preferred food for martens, they provided a suitable alternative to maintain body condition
during years when small rodents were not readily available.
Received: 1 May 1996 / Accepted: 24 February 1997 相似文献
59.
CYP3A4 is recognized as the main enzyme involved in the metabolism of drugs and xenobiotics in the human body and its inhibition may lead to undesirable consequences. Stilbenes, including resveratrol, belong to a group of dietary health-promoting compounds that also act as inhibitors of CYP3A4. The aim of this study was to examine the use of computer modeling of enzyme-ligand interactions to analyze and predict the inhibition of structurally related compounds. To this end, an aldehyde group was attached to resveratrol and the interactions of CYP3A4 with resveratrol, its aldehyde analogue (RA) and a known synthetic inhibitor were studied and compared in two biological models. Specifically, the metabolism of testosterone was examined in a human intestine cell line (Caco-2/TC7) and in rat liver microsomes (RLM). The results demonstrated a weak inhibitory effect of RA on CYP3A4, as compared to resveratrol itself, in both biological models. Human CYP3A4 was more susceptible to inhibition than the commonly used model isozyme from rat. Modeling of the binding site of CYP3A4 revealed a combination of three types of interactions: hydrophobic interactions, electrostatic interactions and hydrogen bonds. A docking simulation revealed that the RA lacked an important binding feature, as compared to resveratrol, and that that difference may be responsible for its lower level of affinity for CYP3A4. Software analysis of binding affinity may serve as a predictive tool for designing new therapeutic compounds in terms of inhibition of CYP3A4 and help to reveal the biochemical nature of the interactions of dietary compounds, herbal compounds and drugs whose metabolism is mediated by this enzyme. 相似文献
60.
Pollinator‐mediated selection on floral size and tube color in Linum pubescens: Can differential behavior and preference in different times of the day maintain dimorphism?
下载免费PDF全文
![点击此处可从《Ecology and evolution》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Diversity of flower traits is often proposed as the outcome of selection exerted by pollinators. Positive directional pollinator‐mediated selection on floral size has been widely shown to reduce phenotypic variance. However, the underlying mechanism of maintaining within‐population floral color polymorphism is poorly understood. Divergent selection, mediated by different pollinators or by both mutualists and antagonists, may create and maintain such polymorphism, but it has rarely been shown to result from differential behavior of one pollinator. We tested whether different behaviors of the same pollinators in morning and evening are associated with dimorphic floral trait in Linum pubescens, a Mediterranean annual plant that exhibits variable within‐population frequencies of dark‐ and light‐colored flower tubes. Usia bicolor bee‐flies, the major pollinators of L. pubescens, are mostly feeding in the flower in the morning, while in the evening they are mostly visiting the flowers for mating. In 2 years of studying L. pubescens in a single large population in the Carmel, Israel, we found in one year that dark‐centered flowers received significantly higher fraction of visits in the morning. Fitness was positively affected by number of visits, but no fitness differences were found between tube‐color morphs, suggesting that both morphs have similar pollination success. Using mediation analysis, we found that flower size was under positive directional pollinator‐mediated selection in both years, but pollinator behavior did not explain entirely this selection, which was possibly mediated also by other agents, such as florivores or a‐biotic stresses. While most pollinator‐mediated selection studies show that flower size signals food reward, in L. pubescens, it may also signal for mating place, which may drive positive selection. While flower size found to be under pollinator‐mediated selection in L. pubescens, differential behavior of the pollinators in morning and evening did not seem to explain flower color polymorphism. 相似文献