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11.
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R Baddam KL Thong TS Avasthi S Shaik KP Yap CS Teh LC Chai N Kumar N Ahmed 《Journal of bacteriology》2012,194(18):5122-5123
Many of the developing countries of the Southeast Asian region are significantly affected by endemic typhoid fever, possibly as a result of marginal living standards. It is an important public health problem in countries such as Papua New Guinea, which is geographically close to some of the foci of endemicity in Asia. The severity of the disease varies in different regions, and this may be attributable to genetic diversity among the native strains. Genome sequence data on strains from different countries are needed to clearly understand their genetic makeup and virulence potential. We describe the genomes of two Salmonella Typhi isolates from patients with fatal and nonfatal cases of typhoid fever in Papua New Guinea. We discuss in brief the underlying sequencing methodology, assembly, genome statistics, and important features of the two draft genomes, which form an essential step in our functional molecular infection epidemiology program centering on typhoid fever. The comparative genomics of these and other isolates would enable us to identify genetic rearrangements and mechanisms responsible for endemicity and the differential severity of pathogenic salmonellae in Papua New Guinea and elsewhere. 相似文献
13.
Han Ming Gan Soo-Sum Lean Zarizal Suhaili Kwai-Lin Thong Chew Chieng Yeo 《Journal of bacteriology》2012,194(21):5979-5980
Acinetobacter baumannii is a major cause of nosocomial infection worldwide. We report the draft genome sequence of A. baumannii AC12, a multidrug-resistant nosocomial strain with additional resistance to carbapenems and polymyxin. The genome data will provide insights into the genetic basis of antimicrobial resistance and its adaptive mechanism. 相似文献
14.
ABSTRACT: The use of herbs as ergogenic aids in exercise and sport is not novel. Ginseng, caffeine, ma huang (also called 'Chinese ephedra'), ephedrine and a combination of both caffeine and ephedrine are the most popular herbs used in exercise and sports. It is believed that these herbs have an ergogenic effect and thus help to improve physical performance. Numerous studies have been conducted to investigate the effects of these herbs on exercise performance. Recently, researchers have also investigated the effects of Eurycoma longifolia Jack on endurance cycling and running performance. These investigators have reported no significant improvement in either cycling or running endurance after supplementation with this herb. As the number of studies in this area is still small, more studies should be conducted to evaluate and substantiate the effects of this herb on sports and exercise performance. For instance, future research on any herbs should take the following factors into consideration: dosage, supplementation period and a larger sample size. 相似文献
15.
Naegleria fowleri, a free-living amoeba-flagellate responsible for primary amoebic meningoencephalitis in man, was observed to cap and internalize surface-bound antibody. These results suggest that the ability of N. fowleri to remove antibody from its surface may allow the amoeba to resist the action of the host's immune system. 相似文献
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Solar Absorber Gel: Solar Absorber Gel: Localized Macro‐Nano Heat Channeling for Efficient Plasmonic Au Nanoflowers Photothermic Vaporization and Triboelectric Generation (Adv. Energy Mater. 25/2018) 下载免费PDF全文
18.
Marc Lecouvey Céline Frochot Laurent Miclo Piotr Orlewski Michel Marraud Jean-Luc Gaillard Manh Thong Cung Régis Vanderesse 《International journal of peptide research and therapeutics》1997,4(4-6):359-364
Summary The conformation of a benzodiazepine-like decapeptide corresponding to the YLGYLEQLLR fragment of a casein has been examined
in a sodium dodecyl sulfate micellar medium using circular dichroism, two-dimensional1H NMR spectroscopy and restrained molecular dynamics simulation. The decapeptide adopts an amphipathic 310-helicoid structure in which the E6...R10 ionic bridge stabilizes the C-terminus. 相似文献
19.
Ren M. Q. Thong P. S. P. Makjanic J. Ponraj D. Watt F. 《Biological trace element research》1999,(1):65-76
The nuclear microscope is now gaining popularity in the field of life sciences. In particular, the combination of proton-induced
X-ray emission to measure the elemental concentrations of inorganic elements, Rutherford backscattering spectrometry to characterize
the organic matrix, and scanning transmission ion microscopy to provide information on the density and structure of the sample
represents a powerful set of techniques that can be applied simultaneously to the specimen under investigation. These techniques
are extremely useful for measuring any imbalances in trace elements in localized regions of biological tissue and, as such,
can provide unique information on many diseases. In this article, we describe the nuclear microscope and its related ionbeam
techniques, and we review the biomedical work carried out using the nuclear microscope in the National University of Singapore. 相似文献
20.
A retrospective study of 932 second trimester terminations between 12-27 weeks gestation was carried out to determine the efficacy of gemeprost for second trimester termination. A single course of 5 x 1 mg gemeprost pessaries was administered every three hours. If abortion had not occurred after the first course of pessaries, a further course of 5 x 1 mg pessaries was administered. Intravenous oxytocin was administered after 36 hours if abortion had not occurred. Eighty per cent and ninety five per cent of patients aborted within 24 and 48 hours respectively. Of the remaining 5 per cent of women, 3 per cent aborted with escalating doses of oxytocin. In the remaining 18 (2 per cent) women, the pregnancies were electively terminated with an alternative method. The median induction-abortion interval was 18.0 hours and 15.0 hours in nulliparous and parous women respectively (P less than 0.0001). The number of pessaries required to induce abortion was not influenced by parity. Significantly more parous women bled more than 500 ml. The incidence of pelvic sepsis (0.1 per cent) and cervical tear (0.1 per cent) was low. Twenty six per cent of women had diarrhoea and 23 per cent vomited following administration of prostaglandin. This study confirmed the efficacy of gemeprost for second trimester termination of pregnancy. This method of termination is safe, non-invasive, simple and has a low complication rate. 相似文献